ID   F9ZUM4_ACICS            Unreviewed;       909 AA.
AC   F9ZUM4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Diguanylate cyclase/phosphodiesterase {ECO:0000313|EMBL:AEK59590.1};
GN   OrderedLocusNames=Atc_m059 {ECO:0000313|EMBL:AEK59590.1};
OS   Acidithiobacillus caldus (strain SM-1).
OG   Plasmid megaplasmid {ECO:0000313|EMBL:AEK59590.1}.
OC   Bacteria; Pseudomonadota; Acidithiobacillia; Acidithiobacillales;
OC   Acidithiobacillaceae; Acidithiobacillus.
OX   NCBI_TaxID=990288 {ECO:0000313|EMBL:AEK59590.1, ECO:0000313|Proteomes:UP000006135};
RN   [1] {ECO:0000313|EMBL:AEK59590.1, ECO:0000313|Proteomes:UP000006135}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM-1 {ECO:0000313|EMBL:AEK59590.1,
RC   ECO:0000313|Proteomes:UP000006135};
RC   PLASMID=Plasmid megaplasmid {ECO:0000313|Proteomes:UP000006135};
RX   PubMed=21703548; DOI=10.1016/j.jgg.2011.04.006;
RA   You X.Y., Guo X., Zheng H.J., Zhang M.J., Liu L.J., Zhu Y.Q., Zhu B.,
RA   Wang S.Y., Zhao G.P., Poetsch A., Jiang C.Y., Liu S.J.;
RT   "Unraveling the Acidithiobacillus caldus complete genome and its central
RT   metabolisms for carbon assimilation.";
RL   J. Genet. Genomics 38:243-252(2011).
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DR   EMBL; CP002574; AEK59590.1; -; Genomic_DNA.
DR   RefSeq; WP_014003688.1; NC_015851.1.
DR   AlphaFoldDB; F9ZUM4; -.
DR   GeneID; 69614380; -.
DR   KEGG; acu:Atc_m059; -.
DR   HOGENOM; CLU_000445_61_1_6; -.
DR   Proteomes; UP000006135; Plasmid megaplasmid.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd18773; PDC1_HK_sensor; 1.
DR   CDD; cd12915; PDC2_DGC_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius}; Plasmid {ECO:0000313|EMBL:AEK59590.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006135};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        310..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          383..517
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          529..782
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   909 AA;  101398 MW;  47D9E303F1CC911A CRC64;
     MNLKTIPKIP AFLTRPITIP PYRWTMSLVF WGTFAGALAF SGWYAWFSWH RYEQNSQYRL
     TLESDMVATV AQKLLDGHAS ALQLLGVQLQ RADALHHPRR ARTLLLDYQK ATSGIASANL
     ITPNGRVIAS TAVPAGNVPP DFRNNPAIWP GFQKVLRTHG IWVYHPLRGP LVDSHWVIRL
     SHTVFSPAGK PLFVVATPLR FNAIEDFLRQ LPLRPGTAVG LIRSDLYIEG RWPIPQGNLS
     KMLAHPVSVG ALLKALQRDP HARQGSYAGF VTVDHTYRFG AFTRLDHYPL TAFVSIPRDS
     WLAAWWRRQI QYPLVFLLIT LGFGMVAYRR ILFLDRRWDL QRQTFERTLT TQATHDGLTN
     LPNRDGLRLV FDQALARAER QERLLAVGFL DLDAFKPVND TYGHAAGDDL LKEIARRLQD
     AVRRTDIVAR LGGDEFVLLL EGLRGMDELD QVLARLQAAI AQPFMIKGKE ISLQASLGLT
     IYPFDESDAD LLLRHADQAM YAAKACPGRA SEGWAQLYHP DLGTITMGDE ILRRDFLQAL
     VAGEVTLRYQ PLVALATGRV AGLEALTRWH REGREKISPD RFLPSLGVRE RQALGHFVLQ
     TGLQQLAQWR DMGLDLFLSV NVTPEEFDSP GFADSVLGIL AAYPGIPPES LVLEVLEIGE
     ILEQEVALEH LQRLRGAGVK IALDDVGSAY ASLLRLKNLP IDEIKIDQGF IRELSNKPQD
     LIFVESLVSL GLAMGVLITV EGVETEAHIA LLREMKINYL QGYAIAKPLE AEAVADFVRT
     FVLGAGDADT PMLALYQHLG WVRAAEESAI NHGIYAYAEL AACPLTTWLH AHAAELSGVE
     ALLVEHEAVH ALGREIFQIR QNGTREELHR LLGQLHVYSH RFQEGLGQAV KTMRENAEAK
     APPPEGANQ
//