ID   F9ZUW1_ACICS            Unreviewed;       831 AA.
AC   F9ZUW1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=Atc_3p {ECO:0000313|EMBL:AEK59810.1};
OS   Acidithiobacillus caldus (strain SM-1).
OG   Plasmid pLAtc3 {ECO:0000313|EMBL:AEK59810.1,
OG   ECO:0000313|Proteomes:UP000006135}.
OC   Bacteria; Pseudomonadota; Acidithiobacillia; Acidithiobacillales;
OC   Acidithiobacillaceae; Acidithiobacillus.
OX   NCBI_TaxID=990288 {ECO:0000313|EMBL:AEK59810.1, ECO:0000313|Proteomes:UP000006135};
RN   [1] {ECO:0000313|EMBL:AEK59810.1, ECO:0000313|Proteomes:UP000006135}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM-1 {ECO:0000313|EMBL:AEK59810.1,
RC   ECO:0000313|Proteomes:UP000006135};
RC   PLASMID=Plasmid pLAtc3 {ECO:0000313|Proteomes:UP000006135};
RX   PubMed=21703548; DOI=10.1016/j.jgg.2011.04.006;
RA   You X.Y., Guo X., Zheng H.J., Zhang M.J., Liu L.J., Zhu Y.Q., Zhu B.,
RA   Wang S.Y., Zhao G.P., Poetsch A., Jiang C.Y., Liu S.J.;
RT   "Unraveling the Acidithiobacillus caldus complete genome and its central
RT   metabolisms for carbon assimilation.";
RL   J. Genet. Genomics 38:243-252(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; CP002577; AEK59810.1; -; Genomic_DNA.
DR   RefSeq; WP_014003882.1; NC_015854.1.
DR   AlphaFoldDB; F9ZUW1; -.
DR   REBASE; 38173; M.AcaSM1ORF3P.
DR   KEGG; acu:Atc_3p; -.
DR   HOGENOM; CLU_008343_0_2_6; -.
DR   Proteomes; UP000006135; Plasmid pLAtc3.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029464; HSDR_N.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR   PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR   Pfam; PF13588; HSDR_N_2; 1.
DR   Pfam; PF02384; N6_Mtase; 3.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Plasmid {ECO:0000313|EMBL:AEK59810.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006135}.
FT   DOMAIN          44..160
FT                   /note="Type I restriction enzyme R protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13588"
FT   DOMAIN          299..371
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
FT   DOMAIN          425..483
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
FT   DOMAIN          544..624
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   831 AA;  93497 MW;  7A5C1A40F21DC31C CRC64;
     MVDTRKPTYI PGSSFPNESD ALHQEGNWLW IPLCKEWRDV TNKPEEIVRQ KFIRTLVEHY
     GYALEQMDQE RRTQHGHKSP RADIVVWQTA MEKEAGRTPV LVVECKTDTI EIQERDYYQG
     ESYTRATGCE FFIATNARHT AVFKLVPGLP GGFVAINEIP KATDWGSARR LKEIRESLRA
     FNRKEFQDLL FVCHSILRDV HKMDPGRAFD TISKILFIKM YVERSGQHGT FTTDYLDRRA
     AVRLPTDPAV HDGLFEQTKA YYKADDLFAA SDKLDISEET FRRIVKQLER FDLSKTGDDI
     KGLAFEKFLG TTFRGELGQF FTPRPVVEFM VDLLNPREGE RICDPASGSG GFLIRAFEHV
     RAQIVADIQR QKDEERARIE ALGLPEEEEE RQIEEAFSRL NRELLPSDDN NKPIDTRVGR
     LAWQCIYGTD AEPRAARTAK MNMIMHGDGH GGIHYHDGLL DINGIFGGRF DVVLTNPPFG
     SNVGRDQKVG GSDETRVPKD EAYLARCREG GYGPAWEESH QSLLAAAAAR KPILDLFEIG
     KGKKNRPTEL IFVERCLNLL KPGGRMGIVL PDGNLNNPSL AWLRRWAEGK AKLLAVVSLP
     EATFRSSNAT VKASLVFLRK FTEAEAAQWE AAWAQAHAEL DARFDQQRDE AHAAYAPRIV
     CGDDAEVQRL LDELAALGIQ RTLLRWQHGE APAYPRQARP TVQNKPAWTG EAAKEHKEHK
     KAAAELKKQA DAALAAVRKR SDALFSELKA KYKAIDEAHT AALWARVRER FDYPVFVAAP
     KSVGITSTGE TGEGVANDLP ELLKAYREFA HWLAQGAQPE ATPNFPGPST A
//