ID FAKD4_BOVIN Reviewed; 632 AA.
AC Q3SZK4;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 08-NOV-2023, entry version 72.
DE RecName: Full=FAST kinase domain-containing protein 4;
DE AltName: Full=Protein TBRG4;
DE AltName: Full=Transforming growth factor beta regulator 4;
DE Flags: Precursor;
GN Name=TBRG4;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in processing of mitochondrial RNA precursors
CC and in stabilization of a subset of mature mitochondrial RNA species,
CC such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6.
CC May play a role in cell cycle progression.
CC {ECO:0000250|UniProtKB:Q969Z0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000250|UniProtKB:Q969Z0}.
CC -!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
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DR EMBL; BC102812; AAI02813.1; -; mRNA.
DR RefSeq; NP_001070435.1; NM_001076967.2.
DR AlphaFoldDB; Q3SZK4; -.
DR SMR; Q3SZK4; -.
DR STRING; 9913.ENSBTAP00000013895; -.
DR PaxDb; 9913-ENSBTAP00000013895; -.
DR GeneID; 767855; -.
DR KEGG; bta:767855; -.
DR CTD; 9238; -.
DR eggNOG; ENOG502QTRE; Eukaryota.
DR InParanoid; Q3SZK4; -.
DR OrthoDB; 5347066at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0035770; C:ribonucleoprotein granule; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0090615; P:mitochondrial mRNA processing; ISS:UniProtKB.
DR GO; GO:0000963; P:mitochondrial RNA processing; IBA:GO_Central.
DR GO; GO:0016071; P:mRNA metabolic process; ISS:UniProtKB.
DR GO; GO:0044528; P:regulation of mitochondrial mRNA stability; ISS:UniProtKB.
DR InterPro; IPR013579; FAST_2.
DR InterPro; IPR010622; FAST_Leu-rich.
DR InterPro; IPR013584; RAP.
DR PANTHER; PTHR21228:SF59; FAST KINASE DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR21228; FAST LEU-RICH DOMAIN-CONTAINING; 1.
DR Pfam; PF06743; FAST_1; 1.
DR Pfam; PF08368; FAST_2; 1.
DR Pfam; PF08373; RAP; 1.
DR SMART; SM00952; RAP; 1.
DR PROSITE; PS51286; RAP; 1.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..112
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 113..632
FT /note="FAST kinase domain-containing protein 4"
FT /id="PRO_0000273025"
FT DOMAIN 562..620
FT /note="RAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
FT REGION 30..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 71641 MW; 175F91A57586348C CRC64;
MAARLVRRCT CLLREAARLA PAVSPVGQLR LPQGTQKPLT SSATSPSSRL PGLLSEFVEK
EQVFTPYTGR QEVEQLIEKA TQPEELLELL GSGHCLQQNH AALALIQLSR LLSEKPKDKA
ALIQDARFWQ LLHLVNSQIT VVWHGTLVKL LRSLYTLGLP ATSKDLRSVE QEVRWRMRRL
KYKHLAFLAE SSATYMQEQG SRELLAELLV HLERRWAEIE DRRMVVAMMM KTGHLSESLM
NRLEDKCLEL VEQFGPEELR KVLVTLAAQN RRSVPLLRAI SYHLVQKPFP LTKSILLDLA
YAYGKLGFHQ TQVFQRLAAD LLPHTPSMTS SEVARCTKSF AFLKWLNLPL FEAFVQHVLD
RAQSITLPHL CNMLLAFARV NFRPEREDPF FSLVHEKLGS ELVGLEPALQ VDVVWALCVL
QQVREAELQA VLCPEFHTQF LGGKSPKDQS TFQKLLHINA TAQLEHPEYT GPLLPTSALV
PSPSALEQKM TPLQKELQET LKGLLGSADK GSFMVPTQYG WVLDAEVLLD TESQLLPLRD
FVAPHLTPPS GSQPLPPGAK RLAFLRWEFP NFNSRSKDLL GRFMLARRHL LAAGFLLVDV
PYYEWMELKS EWQKSAYLKD KMRKAVAEEL AK
//
