ID FAXC_DROME Reviewed; 418 AA.
AC Q95RI5; Q9VV57;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 162.
DE RecName: Full=Failed axon connections;
GN Name=fax; ORFNames=CG4609;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=8647396; DOI=10.1093/genetics/141.2.595;
RA Hill K.K., Bedian V., Juang J.L., Hoffmann F.M.;
RT "Genetic interactions between the Drosophila Abelson (Abl) tyrosine kinase
RT and failed axon connections (fax), a novel protein in axon bundles.";
RL Genetics 141:595-606(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: Together with Abl, involved in embryonic axonal development.
CC {ECO:0000269|PubMed:8647396}.
CC -!- INTERACTION:
CC Q95RI5; Q9U1K1-1: spir; NbExp=2; IntAct=EBI-147695, EBI-3431623;
CC -!- DEVELOPMENTAL STAGE: Not detected in pregastrula embryos. Upon
CC gastrulation, detected in the epidermis and visceral mesoderm. The
CC expression pattern undergoes a pronounced change, such that epidermal
CC expression decreases to background levels while mesodermal expression
CC remains high. Visceral mesoderm expression decreases once formation of
CC the gut tube is complete. Concurrently, central nervous system
CC expression intensifies. Also detected in the peripheral nervous system.
CC {ECO:0000269|PubMed:8647396}.
CC -!- SIMILARITY: Belongs to the FAX family. {ECO:0000305}.
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DR EMBL; AY061352; AAL28900.1; -; mRNA.
DR EMBL; AE014296; AAF49465.2; -; Genomic_DNA.
DR PIR; S58776; S58776.
DR RefSeq; NP_524106.3; NM_079382.7.
DR AlphaFoldDB; Q95RI5; -.
DR BioGRID; 65132; 75.
DR DIP; DIP-18589N; -.
DR IntAct; Q95RI5; 37.
DR STRING; 7227.FBpp0075170; -.
DR PaxDb; 7227-FBpp0075170; -.
DR DNASU; 39826; -.
DR EnsemblMetazoa; FBtr0075412; FBpp0075170; FBgn0014163.
DR GeneID; 39826; -.
DR KEGG; dme:Dmel_CG4609; -.
DR UCSC; CG4609-RA; d. melanogaster.
DR AGR; FB:FBgn0014163; -.
DR CTD; 39826; -.
DR FlyBase; FBgn0014163; fax.
DR VEuPathDB; VectorBase:FBgn0014163; -.
DR eggNOG; KOG4244; Eukaryota.
DR GeneTree; ENSGT00950000182919; -.
DR HOGENOM; CLU_044137_0_0_1; -.
DR InParanoid; Q95RI5; -.
DR OMA; CFPDWED; -.
DR OrthoDB; 3684737at2759; -.
DR PhylomeDB; Q95RI5; -.
DR SignaLink; Q95RI5; -.
DR BioGRID-ORCS; 39826; 0 hits in 1 CRISPR screen.
DR ChiTaRS; fax; fly.
DR GenomeRNAi; 39826; -.
DR PRO; PR:Q95RI5; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0014163; Expressed in wing disc and 27 other cell types or tissues.
DR ExpressionAtlas; Q95RI5; baseline and differential.
DR Genevisible; Q95RI5; DM.
DR GO; GO:0005737; C:cytoplasm; HDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; HDA:FlyBase.
DR GO; GO:0007409; P:axonogenesis; IGI:FlyBase.
DR GO; GO:0036099; P:female germ-line stem cell population maintenance; IMP:FlyBase.
DR CDD; cd03193; GST_C_Metaxin; 1.
DR CDD; cd03080; GST_N_Metaxin_like; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR026928; FAX/IsoI-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12289:SF78; FAILED AXON CONNECTIONS; 1.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF17172; GST_N_4; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01200; SUF1.1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Reference proteome.
FT CHAIN 1..418
FT /note="Failed axon connections"
FT /id="PRO_0000417446"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 418 AA; 47105 MW; E6D36F42D690AC5B CRC64;
MASEVAQIPA EETPAVAAAE KSEEPEKSAA PPADSAAAPA AAPAVEKAED ADGEKKDGEA
GKQDKQQDGE EPKKDEAVAA PVATKSEAPP AQKFNVHKTN FEKDIIYLYQ FSRTPLLPSL
SPYCLKVETW LRLVGLKYEN VDHKMRFRSK KGQLPFIELN GEEIADSAII IKELSSKYEK
YLDSGLTAEQ RNVSYATIAM LENHLIWIIF YWRAKYPDNV LKGYKVNLQH ALGLRLPNSI
LNFFFKITFG RKWFQGTKKL KAHGIGVHSA EEIEEFGKDD LKVLSEMLDC KPFFFGDEPT
TLDVVAFAVL SQLHYLSKDI AYPLRDYMTE KCPNLIGHVS RMKDKCFPDW DEICTKLDLN
AHIPKPEPET KEGKEGGEQE KSNEQEGTEG DKIEKELEKD KSNEKESTEE NKEKEETK
//
