ID FBX40_MOUSE Reviewed; 710 AA.
AC P62932;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=F-box only protein 40;
GN Name=Fbxo40;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND SUBCELLULAR
RP LOCATION.
RX PubMed=17928169; DOI=10.1016/j.gene.2007.08.020;
RA Ye J., Zhang Y., Xu J., Zhang Q., Zhu D.;
RT "FBXO40, a gene encoding a novel muscle-specific F-box protein, is
RT upregulated in denervation-related muscle atrophy.";
RL Gene 404:53-60(2007).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable substrate-recognition component of the SCF (SKP1-
CC CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function
CC in myogenesis. {ECO:0000269|PubMed:17928169}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17928169}.
CC -!- TISSUE SPECIFICITY: Expressed only in heart and skeletal muscle.
CC {ECO:0000269|PubMed:17928169}.
CC -!- DEVELOPMENTAL STAGE: During the development of skeletal muscle, can
CC only be detected 2 weeks after birth. {ECO:0000269|PubMed:17928169}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK036385; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK036385; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS37337.1; -.
DR RefSeq; NP_001032398.1; NM_001037321.1.
DR RefSeq; XP_006521944.1; XM_006521881.2.
DR RefSeq; XP_006521945.1; XM_006521882.3.
DR AlphaFoldDB; P62932; -.
DR SMR; P62932; -.
DR BioGRID; 228886; 4.
DR STRING; 10090.ENSMUSP00000075266; -.
DR GlyGen; P62932; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P62932; -.
DR PhosphoSitePlus; P62932; -.
DR EPD; P62932; -.
DR PaxDb; 10090-ENSMUSP00000075266; -.
DR PeptideAtlas; P62932; -.
DR ProteomicsDB; 271885; -.
DR Antibodypedia; 1237; 136 antibodies from 20 providers.
DR Ensembl; ENSMUST00000075869.13; ENSMUSP00000075266.7; ENSMUSG00000047746.15.
DR Ensembl; ENSMUST00000114806.2; ENSMUSP00000110454.2; ENSMUSG00000047746.15.
DR GeneID; 207215; -.
DR KEGG; mmu:207215; -.
DR UCSC; uc007zdj.1; mouse.
DR AGR; MGI:2443753; -.
DR CTD; 51725; -.
DR MGI; MGI:2443753; Fbxo40.
DR VEuPathDB; HostDB:ENSMUSG00000047746; -.
DR eggNOG; ENOG502QVHX; Eukaryota.
DR GeneTree; ENSGT00950000183204; -.
DR HOGENOM; CLU_013357_0_0_1; -.
DR InParanoid; P62932; -.
DR OMA; EVHISEY; -.
DR OrthoDB; 5397239at2759; -.
DR PhylomeDB; P62932; -.
DR TreeFam; TF343227; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR BioGRID-ORCS; 207215; 6 hits in 77 CRISPR screens.
DR ChiTaRS; Fbxo40; mouse.
DR PRO; PR:P62932; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; P62932; Protein.
DR Bgee; ENSMUSG00000047746; Expressed in hindlimb stylopod muscle and 30 other cell types or tissues.
DR ExpressionAtlas; P62932; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0042692; P:muscle cell differentiation; IEP:UniProtKB.
DR Gene3D; 3.30.40.150; TRAF-like zinc-finger, N-terminal subdomain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR031890; Fbxo30/Fbxo40.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR InterPro; IPR043013; Znf_TRAF_N.
DR PANTHER; PTHR15933:SF1; F-BOX ONLY PROTEIN 40; 1.
DR PANTHER; PTHR15933; PROTEIN CBG16327; 1.
DR Pfam; PF15966; F-box_4; 1.
DR Pfam; PF15965; zf-TRAF_2; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Metal-binding; Reference proteome; Ubl conjugation pathway;
KW Zinc; Zinc-finger.
FT CHAIN 1..710
FT /note="F-box only protein 40"
FT /id="PRO_0000119939"
FT DOMAIN 572..626
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT ZN_FING 53..114
FT /note="TRAF-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT REGION 152..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 79951 MW; 0315C62EBA9BFC45 CRC64;
MGRARKPPPA LHRHCEGCFN RHCHVPVEPS VSCLVISCHL LCGATFHMCK ESEHTLLCPL
EQVPCLNSEY GCPLSMARHK LAKHLQVCPA SVVCCSMEWI RWPNVDSETF LHENIMKETP
SEECLDTALA LQDQKVLFRS LKMVELFPET RDATEEEPDM NGDTSWEETG GAVGGVDARL
APNSCLPATS RQMMELSQEE RDALAKTKEG MDLDKFGKWE SMFSKEHAAS VLTGSLGKSE
DKNGDVAGKE QCSSNVRIGD AEGSAERRGP QESQKSQELP ATMEMTGLAP WQDGVLERLK
TAVDAKDYNM YLVHNGRMLI HFGQMPACTP KERDFVYGNL EAQEVKTVYT FKIPVSYCGK
RARLGDAMLK CRPSEHKAVD TSDLGISVED LPKSDLIKTT LQCALERELK GHVISESRSI
DGLFMDLATQ TYNFEPEQFS SETVLADLLG TAQPGGLHVE LHSECVTRRH NKSSSAFTFT
CNKFFRRDEF PLHFKNVHTD IQSSLDGWFQ HRCPLAYLGC TFVQNHFRPP GQKAKVIYSQ
ELKTFAIKPE VAPELSEKWK SDHLSGRDGK SLNSLTSLPL EVLQYIAGFL DSISLSQLSQ
VSVLMRNICA TLLQERGMVL SQWKKKRYSH GGTSWKVHNQ IWQFSSLFSK INSWEFNDVT
SMSEHLKTCP FNIVERKTDP IRLTSMCQPQ EKARESLVST FRARPRGRHF
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