ID FBXW2_RAT Reviewed; 454 AA.
AC B2RZ17;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=F-box/WD repeat-containing protein 2;
DE AltName: Full=F-box and WD-40 domain-containing protein 2 {ECO:0000312|EMBL:AAI66990.1};
DE AltName: Full=Protein MD6 {ECO:0000250|UniProtKB:Q9UKT8};
GN Name=Fbxw2 {ECO:0000312|RGD:1310460};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:EDL93165.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:AAI66990.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Brown Norway {ECO:0000312|EMBL:AAI66990.1};
RC TISSUE=Kidney {ECO:0000312|EMBL:AAI66990.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex.
CC {ECO:0000250|UniProtKB:Q9UKT8}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
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DR EMBL; CH474001; EDL93165.1; -; Genomic_DNA.
DR EMBL; CH474001; EDL93166.1; -; Genomic_DNA.
DR EMBL; BC166990; AAI66990.1; -; mRNA.
DR RefSeq; NP_001101305.1; NM_001107835.2.
DR RefSeq; XP_006234039.1; XM_006233977.3.
DR RefSeq; XP_008759973.1; XM_008761751.2.
DR RefSeq; XP_008759974.1; XM_008761752.2.
DR AlphaFoldDB; B2RZ17; -.
DR SMR; B2RZ17; -.
DR STRING; 10116.ENSRNOP00000025399; -.
DR iPTMnet; B2RZ17; -.
DR PhosphoSitePlus; B2RZ17; -.
DR PaxDb; 10116-ENSRNOP00000025399; -.
DR PeptideAtlas; B2RZ17; -.
DR GeneID; 311881; -.
DR KEGG; rno:311881; -.
DR UCSC; RGD:1310460; rat.
DR AGR; RGD:1310460; -.
DR CTD; 26190; -.
DR RGD; 1310460; Fbxw2.
DR VEuPathDB; HostDB:ENSRNOG00000018687; -.
DR eggNOG; KOG0274; Eukaryota.
DR HOGENOM; CLU_041488_0_0_1; -.
DR InParanoid; B2RZ17; -.
DR OrthoDB; 587035at2759; -.
DR PhylomeDB; B2RZ17; -.
DR TreeFam; TF333134; -.
DR Reactome; R-RNO-8951664; Neddylation.
DR Reactome; R-RNO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:B2RZ17; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Proteomes; UP000234681; Chromosome 3.
DR Bgee; ENSRNOG00000018687; Expressed in lung and 19 other cell types or tissues.
DR Genevisible; B2RZ17; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR CDD; cd22131; F-box_FBXW2; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR042627; FBXW2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44436; F-BOX/WD REPEAT-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR44436:SF1; F-BOX_WD REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Reference proteome; Repeat; Ubl conjugation pathway;
KW WD repeat.
FT CHAIN 1..454
FT /note="F-box/WD repeat-containing protein 2"
FT /id="PRO_0000391377"
FT DOMAIN 54..101
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 146..183
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 185..221
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 224..265
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 276..314
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT MOD_RES 298
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9UKT8"
SQ SEQUENCE 454 AA; 51408 MW; FFF540F2CC34453A CRC64;
MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET LLKRDFLKLL
PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT ACKNLGWQID DSVQDALHWK
KVYLKAILRM KQLEDHEAFE TSSLIGHSAR VYALYYKDGL LCTGSDDLSA KLWDVSTGQC
VYGIQTHTCA AVKFDEQKLV TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYSDELDI
LVSGSADFAV KVWALSAGTC LNTLTGHTEW VTKVVLQQCK VKSLLHSPGD YILLSADKYE
IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW DFASYDILRV
IKTPEVANLA LLGFGDVFAL LFDNHYLYIM DLRTESLISR WPLPEYRKSK RGSSFLAGEA
SWLNGLDGHN DTGLVFATSM PDHSIHLVLW KEHG
//
