ID FDM3_ARATH Reviewed; 638 AA.
AC Q9LHB1; Q9C7B0;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 24-JAN-2024, entry version 106.
DE RecName: Full=Factor of DNA methylation 3 {ECO:0000303|PubMed:22302148};
GN Name=FDM3 {ECO:0000303|PubMed:22302148};
GN OrderedLocusNames=At3g12550 {ECO:0000312|Araport:AT3G12550};
GN ORFNames=T16H11.4 {ECO:0000312|EMBL:BAB02266.1},
GN T2E22.14 {ECO:0000312|EMBL:AAG51004.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAB02266.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION.
RX PubMed=22302148; DOI=10.1093/nar/gks034;
RA Xie M., Ren G., Costa-Nunes P., Pontes O., Yu B.;
RT "A subgroup of SGS3-like proteins act redundantly in RNA-directed DNA
RT methylation.";
RL Nucleic Acids Res. 40:4422-4431(2012).
CC -!- FUNCTION: Acts in association with FDM4 and FDM5 for RNA-directed DNA
CC methylation (RdDM). {ECO:0000269|PubMed:22302148}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51004.1; Type=Erroneous gene model prediction;
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DR EMBL; AP002055; BAB02266.1; -; Genomic_DNA.
DR EMBL; AC069474; AAG51004.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE75211.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75212.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64203.1; -; Genomic_DNA.
DR RefSeq; NP_001189872.1; NM_001202943.2.
DR RefSeq; NP_001326248.1; NM_001337999.1.
DR RefSeq; NP_187861.2; NM_112090.6.
DR AlphaFoldDB; Q9LHB1; -.
DR SMR; Q9LHB1; -.
DR STRING; 3702.Q9LHB1; -.
DR PaxDb; 3702-AT3G12550-2; -.
DR ProteomicsDB; 232078; -.
DR EnsemblPlants; AT3G12550.1; AT3G12550.1; AT3G12550.
DR EnsemblPlants; AT3G12550.2; AT3G12550.2; AT3G12550.
DR EnsemblPlants; AT3G12550.4; AT3G12550.4; AT3G12550.
DR GeneID; 820435; -.
DR Gramene; AT3G12550.1; AT3G12550.1; AT3G12550.
DR Gramene; AT3G12550.2; AT3G12550.2; AT3G12550.
DR Gramene; AT3G12550.4; AT3G12550.4; AT3G12550.
DR KEGG; ath:AT3G12550; -.
DR Araport; AT3G12550; -.
DR TAIR; AT3G12550; FDM3.
DR eggNOG; ENOG502QRE8; Eukaryota.
DR HOGENOM; CLU_021775_1_1_1; -.
DR InParanoid; Q9LHB1; -.
DR OMA; YYRANYV; -.
DR OrthoDB; 1112799at2759; -.
DR PRO; PR:Q9LHB1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LHB1; baseline and differential.
DR Genevisible; Q9LHB1; AT.
DR GO; GO:0080188; P:gene silencing by RNA-directed DNA methylation; IGI:TAIR.
DR CDD; cd12266; RRM_like_XS; 1.
DR Gene3D; 3.30.70.2890; XS domain; 1.
DR InterPro; IPR045177; FDM1-5/IDN2.
DR InterPro; IPR005379; FDM1-5/IDN2_XH.
DR InterPro; IPR005380; XS_domain.
DR InterPro; IPR038588; XS_domain_sf.
DR InterPro; IPR005381; Znf-XS_domain.
DR PANTHER; PTHR21596:SF52; FACTOR OF DNA METHYLATION 3; 1.
DR PANTHER; PTHR21596; RIBONUCLEASE P SUBUNIT P38; 1.
DR Pfam; PF03469; XH; 1.
DR Pfam; PF03468; XS; 1.
DR Pfam; PF03470; zf-XS; 1.
PE 4: Predicted;
KW Coiled coil; Reference proteome; RNA-mediated gene silencing.
FT CHAIN 1..638
FT /note="Factor of DNA methylation 3"
FT /id="PRO_0000430683"
FT COILED 318..497
FT /evidence="ECO:0000255"
SQ SEQUENCE 638 AA; 74229 MW; F2731C519A5365E3 CRC64;
MNNKLSDFEK NLYKKLKSGK LEVKVSYRTF LCPYCPDNKK KVGLYVDILQ HASGVGNSQS
KKRSLTEKAS HRALAKYLIK DLAHYATSTI SKRLKARTSF IPAETGDAPI IYDDAQFEKL
VWPWKGVLVN IPTTSTEDGR SCTGESGPKL KDELIRRGFN PIRVRTVWDR FGHSGTGIVE
FNRDWNGLQD ALVFKKAYEG DGHGKKDWLC GATDSSLYAW LANADDYYRA NILGENLRKM
GDLKSIYRFA EEEARKDQKL LQRLNFMVEN KQYRLKKLQI KYSQDSVKLK YETEEKEKIL
RAYSEDLTGR QQKSTDHFNR IFADHEKQKV QLESQIKELE IRKLELAKRE AENETQRKIV
AKELEQNAAI NSYVQLSALE QQKTREKAQR LAVDHKMQKE KLHKRIAALE RQLDQKQELE
LEVQQLKSQL SVMRLVELDS GSEIVNKVET FLRDLSETEG ELAHLNQFNQ DLVVQERKSN
DELQEARRAL ISNLRDMGLH IGVKRMGELD TKPFMKAMRI KYCQEDLEDW AVEVIQLWEE
YLKDPDWHPF KRIKLETAET IVEVIDEDDE KLRTLKNELG DDAYQAVANA LLEINEYNPS
GRYISSELWN FREDRKATLE EGVNSLLEQW NQAKHLKS
//
