ID FDSCP_HUMAN Reviewed; 85 AA.
AC Q8NFU4;
DT 28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 24-JAN-2024, entry version 133.
DE RecName: Full=Follicular dendritic cell secreted peptide;
DE Short=FDC secreted protein;
DE Short=FDC-SP;
DE Flags: Precursor;
GN Name=FDCSP; Synonyms=C4orf7; ORFNames=UNQ733/PRO1419;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Tonsil;
RX PubMed=12193705; DOI=10.4049/jimmunol.169.5.2381;
RA Marshall A.J., Du Q., Draves K.E., Shikishima Y., Hayglass K.T.,
RA Clark E.A.;
RT "FDC-SP, a novel secreted protein expressed by follicular dendritic
RT cells.";
RL J. Immunol. 169:2381-2389(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thyroid;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GLYCOSYLATION, STRUCTURE OF CARBOHYDRATES, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=22171320; DOI=10.1074/mcp.m111.013649;
RA Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.;
RT "Human urinary glycoproteomics; attachment site specific analysis of N- and
RT O-linked glycosylations by CID and ECD.";
RL Mol. Cell. Proteomics 11:1-17(2012).
CC -!- FUNCTION: Can bind to the surface of B-lymphoma cells, but not T-
CC lymphoma cells, consistent with a function as a secreted mediator
CC acting upon B-cells.
CC -!- INTERACTION:
CC Q8NFU4; Q12797-6: ASPH; NbExp=3; IntAct=EBI-12210457, EBI-12092171;
CC Q8NFU4; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-12210457, EBI-11956541;
CC Q8NFU4; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-12210457, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Abundantly expressed in tonsil, lymph node, and
CC trachea; strong expression in prostate; lower expression in thyroid,
CC stomach, and colon. {ECO:0000269|PubMed:12193705}.
CC -!- PTM: O-glycosylated with core 1 or possibly core 8 glycans.
CC {ECO:0000269|PubMed:22171320}.
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DR EMBL; AF435080; AAN01116.1; -; mRNA.
DR EMBL; AY358958; AAQ89317.1; -; mRNA.
DR EMBL; BC062213; AAH62213.1; -; mRNA.
DR CCDS; CCDS3537.1; -.
DR RefSeq; NP_694542.1; NM_152997.3.
DR AlphaFoldDB; Q8NFU4; -.
DR BioGRID; 129282; 11.
DR IntAct; Q8NFU4; 3.
DR STRING; 9606.ENSP00000318437; -.
DR GlyCosmos; Q8NFU4; 4 sites, 1 glycan.
DR GlyGen; Q8NFU4; 4 sites, 1 O-linked glycan (4 sites).
DR iPTMnet; Q8NFU4; -.
DR PhosphoSitePlus; Q8NFU4; -.
DR BioMuta; FDCSP; -.
DR MassIVE; Q8NFU4; -.
DR PaxDb; 9606-ENSP00000318437; -.
DR PeptideAtlas; Q8NFU4; -.
DR ProteomicsDB; 73361; -.
DR Antibodypedia; 2662; 96 antibodies from 24 providers.
DR DNASU; 260436; -.
DR Ensembl; ENST00000317987.6; ENSP00000318437.5; ENSG00000181617.6.
DR GeneID; 260436; -.
DR KEGG; hsa:260436; -.
DR MANE-Select; ENST00000317987.6; ENSP00000318437.5; NM_152997.4; NP_694542.1.
DR UCSC; uc003hfd.4; human.
DR AGR; HGNC:19215; -.
DR CTD; 260436; -.
DR DisGeNET; 260436; -.
DR GeneCards; FDCSP; -.
DR HGNC; HGNC:19215; FDCSP.
DR HPA; ENSG00000181617; Group enriched (lymphoid tissue, salivary gland).
DR MIM; 607241; gene.
DR neXtProt; NX_Q8NFU4; -.
DR OpenTargets; ENSG00000181617; -.
DR PharmGKB; PA134922601; -.
DR VEuPathDB; HostDB:ENSG00000181617; -.
DR eggNOG; ENOG502R1D0; Eukaryota.
DR GeneTree; ENSGT00390000015551; -.
DR HOGENOM; CLU_196927_0_0_1; -.
DR InParanoid; Q8NFU4; -.
DR OMA; QRYPWFR; -.
DR PhylomeDB; Q8NFU4; -.
DR TreeFam; TF338548; -.
DR PathwayCommons; Q8NFU4; -.
DR SignaLink; Q8NFU4; -.
DR BioGRID-ORCS; 260436; 11 hits in 1139 CRISPR screens.
DR ChiTaRS; FDCSP; human.
DR GenomeRNAi; 260436; -.
DR Pharos; Q8NFU4; Tbio.
DR PRO; PR:Q8NFU4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8NFU4; Protein.
DR Bgee; ENSG00000181617; Expressed in olfactory segment of nasal mucosa and 120 other cell types or tissues.
DR ExpressionAtlas; Q8NFU4; baseline and differential.
DR Genevisible; Q8NFU4; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR029187; FDC-SP.
DR Pfam; PF15215; FDC-SP; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..85
FT /note="Follicular dendritic cell secreted peptide"
FT /id="PRO_0000021247"
FT REGION 75..83
FT /note="O-glycosylated at one site"
SQ SEQUENCE 85 AA; 9700 MW; 3FEC98BDE883AB07 CRC64;
MKKVLLLITA ILAVAVGFPV SQDQEREKRS ISDSDELASG FFVFPYPYPF RPLPPIPFPR
FPWFRRNFPI PIPESAPTTP LPSEK
//
