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Database: UniProt
Entry: FEOAB_PORGI
LinkDB: FEOAB_PORGI
Original site: FEOAB_PORGI 
ID   FEOAB_PORGI             Reviewed;         844 AA.
AC   Q7MV19;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   08-MAY-2019, entry version 108.
DE   RecName: Full=Fe(2+) transport protein A/Fe(2+) transporter FeoB fusion protein {ECO:0000305};
DE   AltName: Full=Ferrous iron transport protein B;
GN   Name=feoB1 {ECO:0000303|PubMed:15901729};
GN   Synonyms=feoB-2 {ECO:0000303|PubMed:12949112};
GN   OrderedLocusNames=PG_1294;
OS   Porphyromonas gingivalis (strain ATCC BAA-308 / W83).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales;
OC   Porphyromonadaceae; Porphyromonas.
OX   NCBI_TaxID=242619;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-308 / W83;
RX   PubMed=12949112; DOI=10.1128/JB.185.18.5591-5601.2003;
RA   Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E.,
RA   Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L.,
RA   Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J.,
RA   Granger D., Tettelin H., Dong H., Galvin J.L., Duncan M.J.,
RA   Dewhirst F.E., Fraser C.M.;
RT   "Complete genome sequence of the oral pathogenic bacterium
RT   Porphyromonas gingivalis strain W83.";
RL   J. Bacteriol. 185:5591-5601(2003).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 53978 / W50;
RX   PubMed=15901729; DOI=10.1074/jbc.M503896200;
RA   Dashper S.G., Butler C.A., Lissel J.P., Paolini R.A., Hoffmann B.,
RA   Veith P.D., O'Brien-Simpson N.M., Snelgrove S.L., Tsiros J.T.,
RA   Reynolds E.C.;
RT   "A novel Porphyromonas gingivalis FeoB plays a role in manganese
RT   accumulation.";
RL   J. Biol. Chem. 280:28095-28102(2005).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
CC       system. {ECO:0000269|PubMed:15901729}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-
CC       pass membrane protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Cells do not transport Fe(2+). Cells are
CC       avirulent and therefore unable to cause lesions in mice.
CC       {ECO:0000269|PubMed:15901729}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the FeoA family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the TRAFAC class
CC       TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC
CC       9.A.8) family. {ECO:0000255|PROSITE-ProRule:PRU01048}.
DR   EMBL; AE015924; AAQ66370.1; -; Genomic_DNA.
DR   RefSeq; WP_010956271.1; NC_002950.2.
DR   SMR; Q7MV19; -.
DR   STRING; 242619.PG_1294; -.
DR   TCDB; 9.A.8.1.6; the ferrous iron uptake (feob) family.
DR   EnsemblBacteria; AAQ66370; AAQ66370; PG_1294.
DR   KEGG; pgi:PG_1294; -.
DR   PATRIC; fig|242619.8.peg.1196; -.
DR   eggNOG; ENOG4105CE1; Bacteria.
DR   eggNOG; COG0370; LUCA.
DR   eggNOG; COG1918; LUCA.
DR   KO; K04759; -.
DR   OMA; PLGYDWK; -.
DR   OrthoDB; 304844at2; -.
DR   BioCyc; PGIN242619:G1G02-1201-MONOMER; -.
DR   Proteomes; UP000000588; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 2.30.30.90; -; 1.
DR   InterPro; IPR007167; Fe-transptr_FeoA.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   Pfam; PF04023; FeoA; 1.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SMART; SM00899; FeoA; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; GTP-binding;
KW   Ion transport; Iron; Iron transport; Membrane; Nucleotide-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    844       Fe(2+) transport protein A/Fe(2+)
FT                                transporter FeoB fusion protein.
FT                                /FTId=PRO_0000210839.
FT   TRANSMEM    418    438       Helical. {ECO:0000255}.
FT   TRANSMEM    475    495       Helical. {ECO:0000255}.
FT   TRANSMEM    520    540       Helical. {ECO:0000255}.
FT   TRANSMEM    559    579       Helical. {ECO:0000255}.
FT   TRANSMEM    581    601       Helical. {ECO:0000255}.
FT   TRANSMEM    646    666       Helical. {ECO:0000255}.
FT   TRANSMEM    786    806       Helical. {ECO:0000255}.
FT   TRANSMEM    817    837       Helical. {ECO:0000255}.
FT   DOMAIN      126    289       FeoB-type G. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01048}.
FT   NP_BIND     133    140       GTP 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01048}.
FT   NP_BIND     158    162       GTP 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01048}.
FT   NP_BIND     179    182       GTP 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01048}.
FT   NP_BIND     240    243       GTP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01048}.
FT   NP_BIND     269    271       GTP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01048}.
FT   REGION        1     73       FeoA.
FT   REGION       74    844       FeoB.
SQ   SEQUENCE   844 AA;  94623 MW;  B367AD5ED6360906 CRC64;
     MRLSELHTGD QAVIVRVEGR GVFRKRILEM GFVHGKTITV VQCAPLRDPV YYRIMDYNVS
     LRREDAAKIE VELISSNATS SPASNDIGEQ SANPDSNESI PTNPTEDISA KTKSEIEIEV
     KPNGHVIRVA LIGNPNCGKT SIFNRASGAH EHVGNYSGVT VEAKEGLFRH GDYKIEIIDL
     PGTYSLSPYS PEELYIRQYL SEETRPDLVL NVVDTCNLER NLYLTLQLKE MGLPVVIALN
     MFDEFEKKGD TFDYPALSAM LGIPMVPTVG RTGQGLPELF DTLISIHEGR NKIIRPIRIN
     YGSIIEPAVE ALTEKINNQL SLPYSLPARY IAVKLLEGDK EMNRFVGEQP KGLFILSARD
     FALREIDEHL TVARDAESII TDQRYGFIAG ALKETYRSSY KQLKTLTDKI DHIVTHRVLG
     FPLFLLFMFI MFEATFVLGR YPMDWIEAGV GWIGSMVNTF MPDGSFKDLI VDGVIGGVGG
     VIVFLPNILI LYFFISLMED SGYMARAAFI MDKIMHRMGL HGKSFIPLIM GFGCNVPAIM
     ATRTIESKQS RMITMLVTPL MSCSARLPVY LLLAGAFFPD SAGLVLFGLY FLGILLAVLL
     ARLFKKTLFK VEDVPFVMEL PPYRMPTSRS VIVHMWNKAA QYLRKMGSII LLASIVIWFL
     SYYPRYSEEA VLISQIEQIE GNPQLDEEKK TSQIEELNRK AHIEQQEQSY IGRFGKAVQP
     VLAPIGFDWK MSVSLLTGMA AKEVVVSTLG VIYTGDSDDS DEAARRLGER IREDRDAEGN
     HTFSPIIALA LMAFVLIYFP CIATVVAIGR ESGHWKWAVF SIIYSCSLAW IVSFLIYRIG
     ILFF
//
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