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Database: UniProt
Entry: FEOAB_PORGI
LinkDB: FEOAB_PORGI
Original site: FEOAB_PORGI 
ID   FEOAB_PORGI             Reviewed;         844 AA.
AC   Q7MV19;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   12-AUG-2020, entry version 112.
DE   RecName: Full=Fe(2+) transport protein A/Fe(2+) transporter FeoB fusion protein {ECO:0000305};
DE   AltName: Full=Ferrous iron transport protein B;
GN   Name=feoB1 {ECO:0000303|PubMed:15901729};
GN   Synonyms=feoB-2 {ECO:0000303|PubMed:12949112}; OrderedLocusNames=PG_1294;
OS   Porphyromonas gingivalis (strain ATCC BAA-308 / W83).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC   Porphyromonas.
OX   NCBI_TaxID=242619;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-308 / W83;
RX   PubMed=12949112; DOI=10.1128/jb.185.18.5591-5601.2003;
RA   Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E.,
RA   Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L.,
RA   Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J.,
RA   Granger D., Tettelin H., Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E.,
RA   Fraser C.M.;
RT   "Complete genome sequence of the oral pathogenic bacterium Porphyromonas
RT   gingivalis strain W83.";
RL   J. Bacteriol. 185:5591-5601(2003).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 53978 / W50;
RX   PubMed=15901729; DOI=10.1074/jbc.m503896200;
RA   Dashper S.G., Butler C.A., Lissel J.P., Paolini R.A., Hoffmann B.,
RA   Veith P.D., O'Brien-Simpson N.M., Snelgrove S.L., Tsiros J.T.,
RA   Reynolds E.C.;
RT   "A novel Porphyromonas gingivalis FeoB plays a role in manganese
RT   accumulation.";
RL   J. Biol. Chem. 280:28095-28102(2005).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC       {ECO:0000269|PubMed:15901729}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Cells do not transport Fe(2+). Cells are
CC       avirulent and therefore unable to cause lesions in mice.
CC       {ECO:0000269|PubMed:15901729}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the FeoA family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the TRAFAC class
CC       TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC
CC       9.A.8) family. {ECO:0000255|PROSITE-ProRule:PRU01048}.
DR   EMBL; AE015924; AAQ66370.1; -; Genomic_DNA.
DR   RefSeq; WP_010956271.1; NC_002950.2.
DR   SMR; Q7MV19; -.
DR   STRING; 242619.PG_1294; -.
DR   TCDB; 9.A.8.1.6; the ferrous iron uptake (feob) family.
DR   EnsemblBacteria; AAQ66370; AAQ66370; PG_1294.
DR   KEGG; pgi:PG_1294; -.
DR   PATRIC; fig|242619.8.peg.1196; -.
DR   eggNOG; COG0370; Bacteria.
DR   eggNOG; COG1918; Bacteria.
DR   HOGENOM; CLU_013350_3_0_10; -.
DR   KO; K04759; -.
DR   OMA; PLGYDWK; -.
DR   OrthoDB; 304844at2; -.
DR   BioCyc; PGIN242619:G1G02-1201-MONOMER; -.
DR   Proteomes; UP000000588; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 2.30.30.90; -; 1.
DR   InterPro; IPR007167; Fe-transptr_FeoA.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   Pfam; PF04023; FeoA; 1.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SMART; SM00899; FeoA; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; GTP-binding; Ion transport; Iron;
KW   Iron transport; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..844
FT                   /note="Fe(2+) transport protein A/Fe(2+) transporter FeoB
FT                   fusion protein"
FT                   /id="PRO_0000210839"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        475..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        520..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        559..579
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        581..601
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        646..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        786..806
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        817..837
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          126..289
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   NP_BIND         133..140
FT                   /note="GTP 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   NP_BIND         158..162
FT                   /note="GTP 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   NP_BIND         179..182
FT                   /note="GTP 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   NP_BIND         240..243
FT                   /note="GTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   NP_BIND         269..271
FT                   /note="GTP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01048"
FT   REGION          1..73
FT                   /note="FeoA"
FT   REGION          74..844
FT                   /note="FeoB"
SQ   SEQUENCE   844 AA;  94623 MW;  B367AD5ED6360906 CRC64;
     MRLSELHTGD QAVIVRVEGR GVFRKRILEM GFVHGKTITV VQCAPLRDPV YYRIMDYNVS
     LRREDAAKIE VELISSNATS SPASNDIGEQ SANPDSNESI PTNPTEDISA KTKSEIEIEV
     KPNGHVIRVA LIGNPNCGKT SIFNRASGAH EHVGNYSGVT VEAKEGLFRH GDYKIEIIDL
     PGTYSLSPYS PEELYIRQYL SEETRPDLVL NVVDTCNLER NLYLTLQLKE MGLPVVIALN
     MFDEFEKKGD TFDYPALSAM LGIPMVPTVG RTGQGLPELF DTLISIHEGR NKIIRPIRIN
     YGSIIEPAVE ALTEKINNQL SLPYSLPARY IAVKLLEGDK EMNRFVGEQP KGLFILSARD
     FALREIDEHL TVARDAESII TDQRYGFIAG ALKETYRSSY KQLKTLTDKI DHIVTHRVLG
     FPLFLLFMFI MFEATFVLGR YPMDWIEAGV GWIGSMVNTF MPDGSFKDLI VDGVIGGVGG
     VIVFLPNILI LYFFISLMED SGYMARAAFI MDKIMHRMGL HGKSFIPLIM GFGCNVPAIM
     ATRTIESKQS RMITMLVTPL MSCSARLPVY LLLAGAFFPD SAGLVLFGLY FLGILLAVLL
     ARLFKKTLFK VEDVPFVMEL PPYRMPTSRS VIVHMWNKAA QYLRKMGSII LLASIVIWFL
     SYYPRYSEEA VLISQIEQIE GNPQLDEEKK TSQIEELNRK AHIEQQEQSY IGRFGKAVQP
     VLAPIGFDWK MSVSLLTGMA AKEVVVSTLG VIYTGDSDDS DEAARRLGER IREDRDAEGN
     HTFSPIIALA LMAFVLIYFP CIATVVAIGR ESGHWKWAVF SIIYSCSLAW IVSFLIYRIG
     ILFF
//
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