ID FGF8_CHICK Reviewed; 214 AA.
AC Q90722;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 08-NOV-2023, entry version 120.
DE RecName: Full=Fibroblast growth factor 8;
DE Short=FGF-8;
DE AltName: Full=Heparin-binding growth factor 8;
DE Short=HBGF-8;
DE Flags: Precursor;
GN Name=FGF8;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn;
RX PubMed=8674413; DOI=10.1242/dev.122.6.1737;
RA Vogel A., Rodriguez C., Izpisua-Belmonte J.-C.;
RT "Involvement of FGF-8 in initiation, outgrowth and patterning of the
RT vertebrate limb.";
RL Development 122:1737-1750(1996).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation, cell differentiation and cell
CC migration. Involved in initiation, outgrowth and patterning of the
CC limbs.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; U55189; AAB06713.1; -; mRNA.
DR RefSeq; NP_001012785.1; NM_001012767.1.
DR AlphaFoldDB; Q90722; -.
DR SMR; Q90722; -.
DR STRING; 9031.ENSGALP00000032574; -.
DR GlyCosmos; Q90722; 3 sites, No reported glycans.
DR PaxDb; 9031-ENSGALP00000032574; -.
DR GeneID; 396313; -.
DR KEGG; gga:396313; -.
DR CTD; 2253; -.
DR VEuPathDB; HostDB:geneid_396313; -.
DR eggNOG; KOG3885; Eukaryota.
DR InParanoid; Q90722; -.
DR PhylomeDB; Q90722; -.
DR PRO; PR:Q90722; -.
DR Proteomes; UP000000539; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IBA:GO_Central.
DR GO; GO:0035050; P:embryonic heart tube development; IBA:GO_Central.
DR GO; GO:0009880; P:embryonic pattern specification; IDA:AgBase.
DR GO; GO:0060684; P:epithelial-mesenchymal cell signaling; NAS:AgBase.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0003007; P:heart morphogenesis; IBA:GO_Central.
DR GO; GO:0060174; P:limb bud formation; TAS:AgBase.
DR GO; GO:0060173; P:limb development; IDA:AgBase.
DR GO; GO:0035108; P:limb morphogenesis; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IMP:AgBase.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:CACAO.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IMP:AgBase.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR PANTHER; PTHR11486:SF3; FIBROBLAST GROWTH FACTOR 8; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00262; IL1HBGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Growth factor;
KW Mitogen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..214
FT /note="Fibroblast growth factor 8"
FT /id="PRO_0000008972"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 214 AA; 24807 MW; BE5FA3CD13A2BC34 CRC64;
MDPCSSLFSY VFMHLFVLCL QAQVTVQSPP NFTQHVREQS LVTDQLSRRL VRTYQLYSRT
SGKHVQILDN KKINAMAEDG DVHAKLIVET DTFGSRVRIK GAATGFYICM NKKGKLIGKS
NGKGKDCVFT EIVLENNYTA LQNAKYEGWY MAFTRKGRPR KGSKTRQHQR EVHFMKRLPK
GHQTTEPHRR FEFLNYPFNR RSKRTRNSSA SLRP
//
