ID FH4_ORYSJ Reviewed; 849 AA.
AC Q8H8K7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=Formin-like protein 4;
DE AltName: Full=OsFH4;
DE Flags: Precursor;
GN Name=FH4; OrderedLocusNames=Os10g0347800, LOC_Os10g20710;
GN ORFNames=OSJNBb0078C13.8;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12791992; DOI=10.1126/science.1083523;
RA Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15256004; DOI=10.1186/1471-2164-5-44;
RA Cvrckova F., Novotny M., Pickova D., Zarsky V.;
RT "Formin homology 2 domains occur in multiple contexts in angiosperms.";
RL BMC Genomics 5:44-44(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the formin-like family. Class-I subfamily.
CC {ECO:0000305}.
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DR EMBL; AC091666; AAN05367.1; -; Genomic_DNA.
DR EMBL; DP000086; AAP53183.1; -; Genomic_DNA.
DR EMBL; AP008216; BAF26316.1; -; Genomic_DNA.
DR EMBL; AP014966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q8H8K7; -.
DR SMR; Q8H8K7; -.
DR STRING; 39947.Q8H8K7; -.
DR PaxDb; 39947-Q8H8K7; -.
DR eggNOG; KOG1922; Eukaryota.
DR InParanoid; Q8H8K7; -.
DR Proteomes; UP000000763; Chromosome 10.
DR Proteomes; UP000059680; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0045010; P:actin nucleation; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR027643; Formin-like_plant.
DR PANTHER; PTHR23213:SF339; FORMIN-LIKE PROTEIN 4; 1.
DR PANTHER; PTHR23213; FORMIN-RELATED; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..849
FT /note="Formin-like protein 4"
FT /id="PRO_0000318997"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 406..823
FT /note="FH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00774"
FT REGION 36..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..57
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..301
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..361
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 90281 MW; 411C80AA6230004A CRC64;
MPPTLALLLF LALSAVAAVG GAGDVRRVLH EPLFPIEWTP PPSTASPSPP SPDFSSDPST
PATPVDNGGP ALLPPPPPNT VAADVSSSRS GPDPRARGGG GGGTPKAAIV VASAAAAAVL
ALLAFAAAFL LTGRLARHPA AAAAQAHKPP GHAHAGAGSV AGAHADVAGC STAVSPYRKV
RPERARRGMC RDVDTVPSPE LRPLPPLRRG ASALTQGSSD EDAAYYTPGQ RSAGSGGGGG
GEGGGTWSEA SASSPRTTTA SRRSLPSLTS DFFPTTPAAA PVPAPAAAAP PPAPPAPRSR
RTPPRTRFSA GSGAEMNKQM ASPPSNPPPA PPPPPPPPSR FNNTTPKPPP PPPPPEPPTG
PVSARRLLRP LPAEGPSIVI PRAPAMAVTK DNDATAATMS VRTRGEAAGD EPRPKLKPLH
WDKVRTSSDR DMVWDRLKLD EDMIEVLFMN NSTAVAPRMD NPKKVGMPQF KQEERVLDPK
KAQNIAILLR ALNVTLEEVT DALLDGNAEC LGAELLETLV KMAPTKEEEL KLRDFTGDLS
KLGSAERFLK AVLDIPFAFK RVDVMLYRAN FENEVNYLRK SFQTLEAACD DLKGSRLFLK
LLEAVLRTGN RMNVGTNRGE AKAFKLDTLL KLADVKGADG KTTLLHFVVQ EIVRSEDAKS
EKAPENHITN IAKVEQLRRQ GLKVVSGLST ELGNVKRAAT MDFDVLHGYV SKLEAGLGKI
KSVLQLEKQC SQGVNFFATM REFLKEAEQE IEQVRHDEKA ALGRVKEITE YFHGNAVKEE
AHPLRIFMVV RDFLSMLDHV CREVSQQDRT FVGSARSFRI SAANALPILN MQGQKGGRES
SSDGDSPSM
//
