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Database: UniProt
Entry: FL2D_DROPS
LinkDB: FL2D_DROPS
Original site: FL2D_DROPS 
ID   FL2D_DROPS              Reviewed;         560 AA.
AC   Q28XY0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=Pre-mRNA-splicing regulator female-lethal(2)D;
GN   Name=fl(2)d; ORFNames=GA19508;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Associated component of the WMM complex, a complex that
CC       mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification
CC       that plays a role in the efficiency of mRNA splicing and is required
CC       for sex determination. Required for sex determination and dosage
CC       compensation via Sxl alternative splicing: m6A methylation acts as a
CC       key regulator of Sxl pre-mRNA and promotes female-specific alternative
CC       splicing of Sxl, which determines female physiognomy. M6A methylation
CC       is also required for neuronal functions. Required for proper inclusion
CC       of regulated exons in Ubx transcripts, leading to isoforms Ia/b and
CC       IIa/b. {ECO:0000250|UniProtKB:Q9Y091}.
CC   -!- SUBUNIT: Component of the WMM complex, a N6-methyltransferase complex
CC       composed of a catalytic subcomplex, named MAC, and of an associated
CC       subcomplex, named MACOM. The MAC subcomplex is composed of Ime4/Mettl3
CC       and Mettl14. The MACOM subcomplex is composed of fl(2)d, Flacc/Xio,
CC       Hakai, vir, and, in some cases of nito. Interacts with vir and msk.
CC       Part of a complex containing fl(2)d, Sxl and vir.
CC       {ECO:0000250|UniProtKB:Q9Y091}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y091}.
CC   -!- SIMILARITY: Belongs to the fl(2)d family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL26186.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CM000071; EAL26186.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001361607.3; XM_001361570.4.
DR   AlphaFoldDB; Q28XY0; -.
DR   SMR; Q28XY0; -.
DR   STRING; 46245.Q28XY0; -.
DR   EnsemblMetazoa; FBtr0280001; FBpp0278439; FBgn0079504.
DR   GeneID; 4805158; -.
DR   KEGG; dpo:4805158; -.
DR   eggNOG; KOG2991; Eukaryota.
DR   InParanoid; Q28XY0; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0079504; Expressed in insect adult head and 2 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0036396; C:RNA N6-methyladenosine methyltransferase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0048749; P:compound eye development; IEA:EnsemblMetazoa.
DR   GO; GO:0080009; P:mRNA methylation; IEA:EnsemblMetazoa.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0000375; P:RNA splicing, via transesterification reactions; ISS:UniProtKB.
DR   GO; GO:0007530; P:sex determination; IEA:EnsemblMetazoa.
DR   GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR   InterPro; IPR033757; WTAP.
DR   PANTHER; PTHR15217:SF0; PRE-MRNA-SPLICING REGULATOR WTAP; 1.
DR   PANTHER; PTHR15217; WILMS' TUMOR 1-ASSOCIATING PROTEIN; 1.
DR   Pfam; PF17098; Wtap; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Developmental protein; Differentiation; mRNA processing;
KW   mRNA splicing; Nucleus; Reference proteome; Sexual differentiation.
FT   CHAIN           1..560
FT                   /note="Pre-mRNA-splicing regulator female-lethal(2)D"
FT                   /id="PRO_0000308631"
FT   REGION          35..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          541..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          87..218
FT                   /evidence="ECO:0000255"
FT   COILED          262..324
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        87..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        327..350
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..412
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..560
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  61463 MW;  1D5D91EA393BE959 CRC64;
     MSVAAMTMDD QRPLMNSYDK MSTAKYEQNI NLISSGASSG ISAGGVGGGG VPPSGPASPT
     PSGSEESHHH PHHPHHSHHH QHHTPNQEQQ RQQLQQQEQQ HAAVAEAVAA AEQRQRLLED
     EIETLKLEQV RMGQICADAQ RREKILMRRL ANKEQEFQDY VSQIAEYKAQ QAPTALALRT
     ALLDPAVNLL FERLKKELKA TKTKLEETQN ELSAWKFTPD SNTGKRLMAK CRLLYQENEE
     LGKMTSNGRL AKLETELAMQ KSFSEEVKKS QSELDDFLQE LDEDVEGMQS TILFLQQELK
     TTRDRIQTLE KDNAQLKQAH TKDDTVAMAP PTTNGTNKMS PPQTPTPSTI GKLEPIDENV
     ALESKAAHPD YLNGDTRSVN NNEQILPSSV PGEHILPDDV NNSNSNGNGN GNAARLARKR
     NYEEETTTNM VTPTPTPVSY SVEEMTTVRE VSTPRILPPK KSKLRGMPTR RSSQLEEELH
     AAATVAATVA TPLILDNSAT GMVSEEATAV AQPTLASVES GAVCPESTEA GVVAGPARIS
     TRRRSVRMQQ NGAGPLDYST
//
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