ID FL2D_XENTR Reviewed; 393 AA.
AC Q6P4K5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Pre-mRNA-splicing regulator WTAP {ECO:0000305};
DE AltName: Full=Female-lethal(2)D homolog {ECO:0000250|UniProtKB:Q15007};
DE AltName: Full=WT1-associated protein {ECO:0000250|UniProtKB:Q15007};
DE AltName: Full=Wilms tumor 1-associating protein {ECO:0000250|UniProtKB:Q15007};
GN Name=wtap {ECO:0000250|UniProtKB:Q15007};
GN ORFNames=TEgg011e08.1 {ECO:0000303|Ref.1},
GN TEgg064m08.1 {ECO:0000303|Ref.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Associated component of the WMM complex, a complex that
CC mediates N6-methyladenosine (m6A) methylation of RNAs, a modification
CC that plays a role in the efficiency of mRNA splicing and RNA
CC processing. {ECO:0000250|UniProtKB:Q15007}.
CC -!- SUBUNIT: Component of the WMM complex, a N6-methyltransferase complex
CC composed of a catalytic subcomplex, named MAC, and of an associated
CC subcomplex, named MACOM. Component of the MACOM subcomplex.
CC {ECO:0000250|UniProtKB:Q15007}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q15007}.
CC Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q15007}.
CC -!- SIMILARITY: Belongs to the fl(2)d family. {ECO:0000305}.
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DR EMBL; CR760675; CAJ82198.1; -; mRNA.
DR EMBL; CR926261; CAJ81438.1; -; mRNA.
DR EMBL; BC063362; AAH63362.1; -; mRNA.
DR RefSeq; NP_989199.1; NM_203868.1.
DR AlphaFoldDB; Q6P4K5; -.
DR SMR; Q6P4K5; -.
DR STRING; 8364.ENSXETP00000010088; -.
DR PaxDb; 8364-ENSXETP00000045788; -.
DR GeneID; 394807; -.
DR KEGG; xtr:394807; -.
DR AGR; Xenbase:XB-GENE-482822; -.
DR CTD; 9589; -.
DR Xenbase; XB-GENE-482822; wtap.
DR eggNOG; KOG2991; Eukaryota.
DR InParanoid; Q6P4K5; -.
DR OMA; NTDPHED; -.
DR OrthoDB; 2787589at2759; -.
DR Proteomes; UP000008143; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0036396; C:RNA N6-methyladenosine methyltransferase complex; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0080009; P:mRNA methylation; ISS:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR033757; WTAP.
DR PANTHER; PTHR15217:SF0; PRE-MRNA-SPLICING REGULATOR WTAP; 1.
DR PANTHER; PTHR15217; WILMS' TUMOR 1-ASSOCIATING PROTEIN; 1.
DR Pfam; PF17098; Wtap; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Developmental protein; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome.
FT CHAIN 1..393
FT /note="Pre-mRNA-splicing regulator WTAP"
FT /id="PRO_0000308629"
FT REGION 240..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 44312 MW; 82983BAB02EA99AE CRC64;
MTNEEPLPKK VRLNESDFKV LPREELLQRW KQFEAYVQAL ENKYTDLNSN DVTGLRESEE
KLKQQQQDSA RRENILVMRL ATKEQEMQEC TTQIQHLKQV QQPSVAQLRA TMVDPAINLF
FIKMKAELEQ TKDKLEQAQN ELSAWKFTPD SQTGKKLMAK CRMLIQENQE LGRQLSQGRI
AQLEAELALQ KKYSEELKSS QDELNDFIIQ LDEEVEGMQS TILVLQQQLK DSRQQLSQFQ
QQIQTSGNRT PSSESKDEGE TSGKDCGRIL NGPSNGGSSH QRTHSSVGLY REGSSTEEDF
SASPINEGKL PNHSEERTSR GGSSYMNQLS TGYESVDSPT GSENSLTHQS NDTDSNHDSQ
EEKPVSGKGN RTVSSRHLQN GLDSSVNVQG SVL
//
