ID   FLHA_BUCBP              Reviewed;         702 AA.
AC   Q89AN5;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   RecName: Full=Flagellar biosynthesis protein FlhA;
GN   Name=flhA; OrderedLocusNames=bbp_223;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC       apparatus. Together with FliI and FliH, may constitute the export
CC       apparatus of flagellin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016826; AAO26954.1; -; Genomic_DNA.
DR   RefSeq; WP_011091355.1; NC_004545.1.
DR   AlphaFoldDB; Q89AN5; -.
DR   SMR; Q89AN5; -.
DR   STRING; 224915.bbp_223; -.
DR   KEGG; bab:bbp_223; -.
DR   eggNOG; COG1298; Bacteria.
DR   HOGENOM; CLU_015346_3_0_6; -.
DR   OrthoDB; 9759185at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR   Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR   Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR025505; FHIPEP_CS.
DR   InterPro; IPR006301; FlhA.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   NCBIfam; TIGR01398; FlhA; 1.
DR   PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR   PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
DR   PROSITE; PS00994; FHIPEP; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis; Bacterial flagellum protein export;
KW   Cell membrane; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..702
FT                   /note="Flagellar biosynthesis protein FlhA"
FT                   /id="PRO_0000190014"
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   702 AA;  77857 MW;  F8A0C091FCC9ED38 CRC64;
     MANILSIFKT FEIKRLVKFQ TLSGPVLILI ILSMMVLPLA PFILDLFFTF NIALSIVVLL
     MSMFTTKTLE FTSFPTILLF STLLRLALNI ASTRIILLNG HIGSCSAGNV IQAFGHFLVG
     GNFTIGIIVF IILIIINFMV ITKGASRIAE VGARFTLDGM PGKQMAIDAD LNAGLIGEKQ
     AKKRRIEINQ EADFYGSMDG ASKFVRGDAI AGILIMIVNI IGGLVIGILQ HNMTFSQAAQ
     VYTILTIGDG LVAQIPALVV STASGVIVTR VSTDQNVSEQ IVSQLFCNPQ VILLSGIVLG
     VLGLVPGMPN IIFLIFTTLL FFISWLIYRN PVIFTNFEST MKKIDNTNFC NISDASWNDV
     QLEGSISIEL GNLLIPMIKV NSKKSNLLDK IRNVRKKCAK NIGFLPPLVH IRDNNNLPGN
     CYCILIKGIE ISKGTVQCGK FLAINSGNAS GPLPLPAEET SDPIFKFKSF WITSELINQA
     KQKGYNIAED STVISTHLNH IILTHISLLF GRQEAQQLLD YVSKFCPKLI EDLIPNSINL
     TIFHQVLQNL LIENVPIRDM QTILETLITH APNYQNDSQI LTSLVRISLG KLIIQNIFQN
     NKIEVIKFDS KLEQILLKTI ANKDSVLEPG LYNYIVVKLQ QEYNNCKLKN IPCVLLVHHN
     LRVFIAKMLL KNIPKIFVLS NLELEDVTKI YTTNIIGDQT KT
//