ID FOXL1_MOUSE Reviewed; 336 AA.
AC Q64731; B2RQ86;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 24-JAN-2024, entry version 152.
DE RecName: Full=Forkhead box protein L1;
DE AltName: Full=Forkhead-related protein FKHL11;
DE AltName: Full=Transcription factor FKH-6;
GN Name=Foxl1; Synonyms=Fkh6, Fkhl11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129;
RX PubMed=8674414; DOI=10.1242/dev.122.6.1751;
RA Kaestner K.H., Bleckmann S.C., Monaghan A.P., Schlondorff J., Mincheva A.,
RA Lichter P., Schuetz G.;
RT "Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible
RT implications for mesoderm development.";
RL Development 122:1751-1758(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-150.
RC STRAIN=129;
RX PubMed=7689224; DOI=10.1073/pnas.90.16.7628;
RA Kaestner K.H., Lee K.H., Schloendorff J., Hiemisch H., Monaghan A.P.,
RA Schuetz G.;
RT "Six members of the mouse forkhead gene family are developmentally
RT regulated.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:7628-7631(1993).
RN [5]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=9203584; DOI=10.1101/gad.11.12.1583;
RA Kaestner K.H., Silberg D.G., Traber P.G., Schutz G.;
RT "The mesenchymal winged helix transcription factor Fkh6 is required for the
RT control of gastrointestinal proliferation and differentiation.";
RL Genes Dev. 11:1583-1595(1997).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=15155178; DOI=10.1152/ajpgi.00136.2004;
RA Katz J.P., Perreault N., Goldstein B.G., Chao H.H., Ferraris R.P.,
RA Kaestner K.H.;
RT "Foxl1 null mice have abnormal intestinal epithelia, postnatal growth
RT retardation, and defective intestinal glucose uptake.";
RL Am. J. Physiol. 287:G856-G864(2004).
RN [7]
RP FUNCTION.
RX PubMed=19049965; DOI=10.1074/jbc.m808103200;
RA Madison B.B., McKenna L.B., Dolson D., Epstein D.J., Kaestner K.H.;
RT "FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial
RT proliferation in the developing stomach and intestine.";
RL J. Biol. Chem. 284:5936-5944(2009).
CC -!- FUNCTION: Transcription factor required for proper proliferation and
CC differentiation in the gastrointestinal epithelium. Target gene of the
CC hedgehog (Hh) signaling pathway via GLI2 and GLI3 transcription
CC factors. {ECO:0000269|PubMed:19049965, ECO:0000269|PubMed:9203584}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DISRUPTION PHENOTYPE: Deficient mice show postnatal growth retardation
CC secondary to severe structural abnormalities of the stomach, duodenum,
CC jejunum and decreased intestinal uptake of D-glucose and levels of the
CC intestinal D-glucose transporter Slc5a1. {ECO:0000269|PubMed:15155178,
CC ECO:0000269|PubMed:9203584}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA63243.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X92498; CAA63243.1; ALT_FRAME; Genomic_DNA.
DR EMBL; CH466525; EDL11654.1; -; Genomic_DNA.
DR EMBL; BC137805; AAI37806.1; -; mRNA.
DR EMBL; BC137806; AAI37807.1; -; mRNA.
DR EMBL; X71944; CAA50746.1; -; Genomic_DNA.
DR CCDS; CCDS59744.1; -.
DR PIR; F47746; F47746.
DR RefSeq; NP_032050.2; NM_008024.2.
DR AlphaFoldDB; Q64731; -.
DR SMR; Q64731; -.
DR BioGRID; 199698; 1.
DR IntAct; Q64731; 1.
DR STRING; 10090.ENSMUSP00000137732; -.
DR iPTMnet; Q64731; -.
DR PhosphoSitePlus; Q64731; -.
DR MaxQB; Q64731; -.
DR PaxDb; 10090-ENSMUSP00000137732; -.
DR ProteomicsDB; 271593; -.
DR Antibodypedia; 17198; 503 antibodies from 28 providers.
DR DNASU; 14241; -.
DR Ensembl; ENSMUST00000181609.2; ENSMUSP00000137732.2; ENSMUSG00000097084.2.
DR GeneID; 14241; -.
DR KEGG; mmu:14241; -.
DR UCSC; uc009nrs.1; mouse.
DR AGR; MGI:1347469; -.
DR CTD; 2300; -.
DR MGI; MGI:1347469; Foxl1.
DR VEuPathDB; HostDB:ENSMUSG00000097084; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162251; -.
DR HOGENOM; CLU_052451_0_0_1; -.
DR InParanoid; Q64731; -.
DR OMA; SCFPLHF; -.
DR OrthoDB; 5385885at2759; -.
DR PhylomeDB; Q64731; -.
DR BioGRID-ORCS; 14241; 3 hits in 77 CRISPR screens.
DR PRO; PR:Q64731; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q64731; Protein.
DR Bgee; ENSMUSG00000097084; Expressed in female urethra and 67 other cell types or tissues.
DR Genevisible; Q64731; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0007507; P:heart development; ISO:MGI.
DR GO; GO:0061146; P:Peyer's patch morphogenesis; IMP:MGI.
DR GO; GO:0030166; P:proteoglycan biosynthetic process; IMP:MGI.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; TAS:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0030111; P:regulation of Wnt signaling pathway; IMP:MGI.
DR GO; GO:0007495; P:visceral mesoderm-endoderm interaction involved in midgut development; IMP:MGI.
DR CDD; cd20027; FH_FOXL1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047514; FH_FOXL1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR PANTHER; PTHR11829:SF204; FORKHEAD BOX PROTEIN L1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..336
FT /note="Forkhead box protein L1"
FT /id="PRO_0000091860"
FT DNA_BIND 48..139
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 140..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 175
FT /note="L -> LV (in Ref. 2; CAA50746/CAA63243)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 35793 MW; 244437F043BA7F43 CRC64;
MSHLFSPPLA ALAASPLLYV YSPERPGLPL AFAPAAALAG PGRVEPPQKP PYSYIALIAM
AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN LSLNECFVKV PREKGRPGKG
SYWTLDPRCL DMFENGNYRR RKRKPKPAAG SPEAKRTRVE PPESEVGCDV GSPDLATALP
TRAPDRSQSP AVGTARPALL PWPGPEPRDP DADLTVQGAG AVASGQLQRP AHHLGSPLCP
APSGSPKGSK SKSFSIDSIL AVRPTPASGA EAPGIPKPVP GALGSSLLAA SSGLAPPFNA
SLVFDAHVQG GFSQLGIPFL SYFPLQVPEA TVLRFH
//
