ID FXI1C_XENTR Reviewed; 358 AA.
AC Q28D67;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Forkhead box protein I1c;
DE Short=FoxI1c;
GN Name=foxi1c {ECO:0000250|UniProtKB:Q8JIT5}; ORFNames=TGas113f01.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ83910.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83910.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable transcription factor.
CC {ECO:0000250|UniProtKB:Q8JIT5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
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DR EMBL; CR855676; CAJ83910.1; -; mRNA.
DR RefSeq; NP_001016787.1; NM_001016787.2.
DR AlphaFoldDB; Q28D67; -.
DR SMR; Q28D67; -.
DR PaxDb; 8364-ENSXETP00000004119; -.
DR GeneID; 549541; -.
DR KEGG; xtr:549541; -.
DR AGR; Xenbase:XB-GENE-5996107; -.
DR CTD; 549541; -.
DR Xenbase; XB-GENE-5996107; foxi4.1.
DR eggNOG; KOG2294; Eukaryota.
DR InParanoid; Q28D67; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000008143; Chromosome 1.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR PANTHER; PTHR11829:SF372; FORKHEAD BOX PROTEIN I2; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..358
FT /note="Forkhead box protein I1c"
FT /id="PRO_0000258005"
FT DNA_BIND 106..200
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 39479 MW; 0DD7C14706E0BA18 CRC64;
MNSIHLPSHQ RTSAPGLHQH RPKGAQEASE MAVYCDNFSM YHQQNLHSSQ RAPNYGIGDY
APPTNPYLWL GGPGVSNSPS NSSSFCGTDL SWLSVASQEE LLKVVRPPYS YSALIAMAIQ
NAPEKKLTLS QIYQYVADNF PFYKRSKAGW QNSIRHNLSL NDCFKKVPRD EDDPGKGNYW
TLDPNCEKMF DNGNFRRKRK RRSDSSSAEA VTVKGEEGRP ALGGKGGESP LMLTPSSPEL
EAASDGRKST SPSGITSSPC LNNFFSSMTS LDTTSVNRQM SMGLVNELSQ RNITGLGSFT
SGSVAEPSVD LQDNSLHLNR PSYYSTLSST HQNNQFNSHF YNTFSVNSLI YAREGSEV
//
