ID FXYD6_MOUSE Reviewed; 94 AA.
AC Q9D164; Q99NC3; Q9CXD0;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 24-JAN-2024, entry version 147.
DE RecName: Full=FXYD domain-containing ion transport regulator 6;
DE AltName: Full=PLM-like protein;
DE AltName: Full=Phosphohippolin;
DE Flags: Precursor;
GN Name=Fxyd6; Synonyms=Plp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RA Saito S., Matoba R., Kato K., Matsubara K.;
RT "A novel PLM-like ion channel gene expressed in the nervous system.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=FVB/N; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 25-37 AND 70-91, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (APR-2007) to UniProtKB.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D164-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D164-2; Sequence=VSP_001585;
CC -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
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DR EMBL; AB032010; BAB40451.2; -; mRNA.
DR EMBL; AK003888; BAB23058.1; -; mRNA.
DR EMBL; AK018354; BAB31174.1; -; mRNA.
DR EMBL; BC042579; AAH42579.1; -; mRNA.
DR EMBL; BC051127; AAH51127.1; -; mRNA.
DR CCDS; CCDS23133.1; -. [Q9D164-1]
DR RefSeq; NP_071287.1; NM_022004.6. [Q9D164-1]
DR AlphaFoldDB; Q9D164; -.
DR SMR; Q9D164; -.
DR STRING; 10090.ENSMUSP00000083101; -.
DR PhosphoSitePlus; Q9D164; -.
DR SwissPalm; Q9D164; -.
DR MaxQB; Q9D164; -.
DR PaxDb; 10090-ENSMUSP00000083101; -.
DR PeptideAtlas; Q9D164; -.
DR ProteomicsDB; 266894; -. [Q9D164-1]
DR ProteomicsDB; 266895; -. [Q9D164-2]
DR Antibodypedia; 45759; 144 antibodies from 22 providers.
DR DNASU; 59095; -.
DR Ensembl; ENSMUST00000085939.8; ENSMUSP00000083101.7; ENSMUSG00000066705.8. [Q9D164-1]
DR Ensembl; ENSMUST00000217381.2; ENSMUSP00000150813.2; ENSMUSG00000066705.8. [Q9D164-2]
DR GeneID; 59095; -.
DR KEGG; mmu:59095; -.
DR UCSC; uc009pfs.1; mouse. [Q9D164-1]
DR UCSC; uc009pft.1; mouse. [Q9D164-2]
DR AGR; MGI:1890226; -.
DR CTD; 53826; -.
DR MGI; MGI:1890226; Fxyd6.
DR VEuPathDB; HostDB:ENSMUSG00000066705; -.
DR eggNOG; ENOG502S570; Eukaryota.
DR GeneTree; ENSGT00940000153062; -.
DR HOGENOM; CLU_171208_3_0_1; -.
DR InParanoid; Q9D164; -.
DR OMA; VENPFIY; -.
DR OrthoDB; 4637393at2759; -.
DR PhylomeDB; Q9D164; -.
DR TreeFam; TF333443; -.
DR Reactome; R-MMU-5578775; Ion homeostasis.
DR Reactome; R-MMU-936837; Ion transport by P-type ATPases.
DR BioGRID-ORCS; 59095; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Fxyd6; mouse.
DR PRO; PR:Q9D164; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9D164; Protein.
DR Bgee; ENSMUSG00000066705; Expressed in extra-ocular muscle and 237 other cell types or tissues.
DR Genevisible; Q9D164; MM.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0045211; C:postsynaptic membrane; IDA:SynGO.
DR GO; GO:0042734; C:presynaptic membrane; IDA:SynGO.
DR GO; GO:0017080; F:sodium channel regulator activity; IBA:GO_Central.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0043269; P:regulation of monoatomic ion transport; IEA:InterPro.
DR Gene3D; 1.20.5.780; Single helix bin; 1.
DR InterPro; IPR047297; FXYD_motif.
DR InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR PANTHER; PTHR14132:SF15; FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 6-RELATED; 1.
DR PANTHER; PTHR14132; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA; 1.
DR Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR PROSITE; PS01310; FXYD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Ion channel;
KW Ion transport; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..17
FT /evidence="ECO:0000250|UniProtKB:Q91XV6"
FT CHAIN 18..94
FT /note="FXYD domain-containing ion transport regulator 6"
FT /id="PRO_0000010374"
FT TOPO_DOM 18..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..94
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 20
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_001585"
SQ SEQUENCE 94 AA; 10374 MW; 02E22B0BE349CB51 CRC64;
METVLVLCSL LAPVVLASAA EKEKEKDPFY YDYQTLRIGG LVFAVVLFSV GILLILSRRC
KCSFNQKPRA PGDEEAQVEN LITTNAAEPQ KAEN
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