ID FYV10_NEUCR Reviewed; 410 AA.
AC Q7S2X0;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 24-JAN-2024, entry version 96.
DE RecName: Full=Protein fyv-10;
GN Name=fyv-10; ORFNames=NCU09000;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Involved in the proteasome-dependent degradation of fructose-
CC 1,6-bisphosphatase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FYV10 family. {ECO:0000305}.
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DR EMBL; CM002238; EAA29792.1; -; Genomic_DNA.
DR RefSeq; XP_959028.1; XM_953935.2.
DR AlphaFoldDB; Q7S2X0; -.
DR SMR; Q7S2X0; -.
DR STRING; 367110.Q7S2X0; -.
DR PaxDb; 5141-EFNCRP00000008981; -.
DR EnsemblFungi; EAA29792; EAA29792; NCU09000.
DR GeneID; 3875150; -.
DR KEGG; ncr:NCU09000; -.
DR VEuPathDB; FungiDB:NCU09000; -.
DR HOGENOM; CLU_027445_2_0_1; -.
DR InParanoid; Q7S2X0; -.
DR OMA; CHDNRSK; -.
DR OrthoDB; 1429623at2759; -.
DR Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0034657; C:GID complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:UniProt.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR InterPro; IPR013144; CRA_dom.
DR InterPro; IPR024964; CTLH/CRA.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR045098; Fyv10_fam.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR044063; ZF_RING_GID.
DR PANTHER; PTHR12170:SF2; E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA; 1.
DR PANTHER; PTHR12170; MACROPHAGE ERYTHROBLAST ATTACHER-RELATED; 1.
DR Pfam; PF10607; CTLH; 1.
DR SMART; SM00757; CRA; 1.
DR SMART; SM00668; CTLH; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS51867; ZF_RING_GID; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..410
FT /note="Protein fyv-10"
FT /id="PRO_0000292463"
FT DOMAIN 125..157
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT DOMAIN 163..220
FT /note="CTLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT ZN_FING 335..396
FT /note="RING-Gid-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01215"
FT REGION 310..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 46471 MW; 36F1C35DF9249F9C CRC64;
MADHEASKIN HDNHLLLDQP LLRLPYELLR KNFRSAHFTV EKESTTLNKL LKETAKGSLD
GKTSPEDVVK NLDTMIAKMR GMKRKLSTYA NEETRLYKQL DARVAHLREL SDMHSVEDVK
YEAWSRKRLD RLLVDYMLRH GYNTSAQALA NEREMHDLVD VETFLTMSKI RESLENGSVT
EALAWCNDNK KELRKLQSNL EFLLRCQQYI ELLRINTPSK SVEAITHAKK YIAPFQEQYP
DEVREMAALL AHRPTDKNLP LKYAAWYSPD RWTKLATSFV EAHNKLLGLP TFPLLHTALS
SGLSALKTPA CHGTQKTTSS SQPGHSQTSM TSTVCPICSI ELNELAKNVP YAHHSKSHLD
NDLLLLPNGR VYGQAKLDEY AAKAGLAEGQ VKDLVTGEVY SRTALKKVFA
//
