ID G0EC95_PYRF1 Unreviewed; 714 AA.
AC G0EC95;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA-binding protein MutS2 {ECO:0000256|HAMAP-Rule:MF_00971};
GN Name=mutS2 {ECO:0000256|HAMAP-Rule:MF_00971};
GN OrderedLocusNames=Pyrfu_1608 {ECO:0000313|EMBL:AEM39465.1};
OS Pyrolobus fumarii (strain DSM 11204 / 1A).
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales; Pyrodictiaceae;
OC Pyrolobus.
OX NCBI_TaxID=694429 {ECO:0000313|EMBL:AEM39465.1, ECO:0000313|Proteomes:UP000001037};
RN [1] {ECO:0000313|EMBL:AEM39465.1, ECO:0000313|Proteomes:UP000001037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11204 / 1A {ECO:0000313|Proteomes:UP000001037};
RX PubMed=21886865;
RA Anderson I., Goker M., Nolan M., Lucas S., Hammon N., Deshpande S.,
RA Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Huntemann M.,
RA Liolios K., Ivanova N., Pagani I., Mavromatis K., Ovchinikova G., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M., Huber H.,
RA Yasawong M., Rohde M., Spring S., Abt B., Sikorski J., Wirth R.,
RA Detter J.C., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of the hyperthermophilic chemolithoautotroph
RT Pyrolobus fumarii type strain (1A).";
RL Stand. Genomic Sci. 4:381-392(2011).
CC -!- FUNCTION: Has ATPase and non-specific DNA-binding activities.
CC {ECO:0000256|HAMAP-Rule:MF_00971}.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00971};
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. Archaeal
CC Muts2 subfamily. {ECO:0000256|HAMAP-Rule:MF_00971}.
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DR EMBL; CP002838; AEM39465.1; -; Genomic_DNA.
DR RefSeq; WP_014027142.1; NC_015931.1.
DR AlphaFoldDB; G0EC95; -.
DR STRING; 694429.Pyrfu_1608; -.
DR GeneID; 11138795; -.
DR KEGG; pfm:Pyrfu_1608; -.
DR eggNOG; arCOG02895; Archaea.
DR HOGENOM; CLU_026764_0_0_2; -.
DR InParanoid; G0EC95; -.
DR OrthoDB; 15514at2157; -.
DR Proteomes; UP000001037; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00971; MutS2_archaea; 1.
DR InterPro; IPR012401; DNA-bd_MutS2_arc.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF125; DNA-BINDING PROTEIN MUTS2; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF029254; MutS_C_archaeal; 1.
DR SMART; SM00534; MUTSac; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00971};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00971}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00971};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00971}; Reference proteome {ECO:0000313|Proteomes:UP000001037}.
FT DOMAIN 517..712
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
FT BINDING 524..531
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00971"
SQ SEQUENCE 714 AA; 78804 MW; 58E0EF573E6E5A97 CRC64;
MVLFAAGNVG KLSDIPGVGP RIAEKLVEYF GDEEEALQAI LSCRISLISE AIGRAAATRL
VHGLYRALFG AWPRDVAAND DAWKLFQAAK GVILKKVSSP AGRDVLACFL PMPSTGVKEA
KRRLTLVKSL QEAIRELPRE SIEALRSALS KLEWPKPVKI SRIKRTLIII GDNVAYEKAK
RTLSNLVDIV LVNDADEVDR VAAERGEALV YDPDGVYAGP LPRVLELSVA EVVPEAIVEY
FRVNWRVIEA VVDALEALGR WAPDILKIVG LDFDPTRVLN RLREALVFKG GEVAPDIDPE
YQRLYTALTN LDRVVDEIEL WVNNEVQTRL EKLEVRLSAA QFLRLFRVLR EGGVEGVDLP
EEIYEVFEEV AEEAEKRVVE KLHLTPDEAE AMRGLVPRTP LFPIELNRDK VEELRRVLRA
KLSVKRFEVM QKLASKLVGV KAKLERLVDA LALLDVLLAQ VELVGDGVAG VPEVSSEYLG
VGFVDAIEAS LVGKPNVQRI SYVVGSTPYK PDDTKGERVV LLTGANSGGK TTLLKTICET
ALLAQSGLVV LARQAWIGAF DYVHFFSKPS GMVDAGALEA TLRILAAIVA GGSGRRLVLV
DELEAATEAG AAARIMSVVV EKLCSRDNIV AVIVTHMARE ILSNVKKVEG CIRVDGIEAR
GLDENYNLIV DRNPRYYYLA RSTPELVVRR LLYRAKGREE REFYETLLRV LSGA
//
