ID G0EGV7_PYRF1 Unreviewed; 224 AA.
AC G0EGV7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=UMP kinase {ECO:0000256|ARBA:ARBA00012899};
DE EC=2.7.4.22 {ECO:0000256|ARBA:ARBA00012899};
DE AltName: Full=Uridine monophosphate kinase {ECO:0000256|ARBA:ARBA00032092};
GN OrderedLocusNames=Pyrfu_1397 {ECO:0000313|EMBL:AEM39255.1};
OS Pyrolobus fumarii (strain DSM 11204 / 1A).
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales; Pyrodictiaceae;
OC Pyrolobus.
OX NCBI_TaxID=694429 {ECO:0000313|EMBL:AEM39255.1, ECO:0000313|Proteomes:UP000001037};
RN [1] {ECO:0000313|EMBL:AEM39255.1, ECO:0000313|Proteomes:UP000001037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11204 / 1A {ECO:0000313|Proteomes:UP000001037};
RX PubMed=21886865;
RA Anderson I., Goker M., Nolan M., Lucas S., Hammon N., Deshpande S.,
RA Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Huntemann M.,
RA Liolios K., Ivanova N., Pagani I., Mavromatis K., Ovchinikova G., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M., Huber H.,
RA Yasawong M., Rohde M., Spring S., Abt B., Sikorski J., Wirth R.,
RA Detter J.C., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of the hyperthermophilic chemolithoautotroph
RT Pyrolobus fumarii type strain (1A).";
RL Stand. Genomic Sci. 4:381-392(2011).
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway;
CC UDP from UMP (UMPK route): step 1/1. {ECO:0000256|ARBA:ARBA00004791}.
CC -!- SIMILARITY: Belongs to the UMP kinase family.
CC {ECO:0000256|ARBA:ARBA00007614}.
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DR EMBL; CP002838; AEM39255.1; -; Genomic_DNA.
DR AlphaFoldDB; G0EGV7; -.
DR STRING; 694429.Pyrfu_1397; -.
DR KEGG; pfm:Pyrfu_1397; -.
DR eggNOG; arCOG00858; Archaea.
DR HOGENOM; CLU_079546_0_0_2; -.
DR InParanoid; G0EGV7; -.
DR OrthoDB; 372251at2157; -.
DR Proteomes; UP000001037; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009041; F:UMP/dUMP kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR011818; Uridylate_kinase_arch/spir.
DR NCBIfam; TIGR02076; pyrH_arch; 1.
DR PANTHER; PTHR42833; URIDYLATE KINASE; 1.
DR PANTHER; PTHR42833:SF4; URIDYLATE KINASE PUMPKIN, CHLOROPLASTIC; 1.
DR Pfam; PF00696; AA_kinase; 1.
DR SUPFAM; SSF53633; Carbamate kinase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AEM39255.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Reference proteome {ECO:0000313|Proteomes:UP000001037};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..200
FT /note="Aspartate/glutamate/uridylate kinase"
FT /evidence="ECO:0000259|Pfam:PF00696"
SQ SEQUENCE 224 AA; 23966 MW; 5FFFAC9D67140948 CRC64;
MSRPSIVVKI SGKLVEDTGS LQGLVGVLRE LINEYRVAIV VGGGRLARKY VSFLGSLQAP
KSLMDIAGIE ASRFYARVLA LALGSTAPVP RSYEEFLTQL ATGVNPIVAG GFQPGQSTTA
VAALIAEAMR AERLVIATVV DGVFDRDPAK HPDAKLFPRL SITEALRVIE SSTEPGRYEL
LEPYAASILQ RSGTRVYIVN GRHPERVLEA ARGGEPIGTL LTPD
//
