ID G0HJR3_THES4 Unreviewed; 334 AA.
AC G0HJR3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Thiamine pyrophosphate-dependent dehydrogenase, E1 component alpha subunit {ECO:0000313|EMBL:AEK73156.1};
GN OrderedLocusNames=GQS_06290 {ECO:0000313|EMBL:AEK73156.1};
OS Thermococcus sp. (strain CGMCC 1.5172 / 4557).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=1042877 {ECO:0000313|EMBL:AEK73156.1, ECO:0000313|Proteomes:UP000000874};
RN [1] {ECO:0000313|EMBL:AEK73156.1, ECO:0000313|Proteomes:UP000000874}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.5172 / 4557 {ECO:0000313|Proteomes:UP000000874};
RX PubMed=21914870; DOI=10.1128/JB.05851-11;
RA Wang X., Gao Z., Xu X., Ruan L.;
RT "Complete genome sequence of Thermococcus sp. strain 4557, a
RT hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent
RT area.";
RL J. Bacteriol. 193:5544-5545(2011).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP002920; AEK73156.1; -; Genomic_DNA.
DR RefSeq; WP_014012838.1; NC_015865.1.
DR AlphaFoldDB; G0HJR3; -.
DR STRING; 1042877.GQS_06290; -.
DR GeneID; 11015932; -.
DR KEGG; the:GQS_06290; -.
DR PATRIC; fig|1042877.9.peg.1232; -.
DR eggNOG; arCOG01054; Archaea.
DR HOGENOM; CLU_029393_5_0_2; -.
DR OrthoDB; 25266at2157; -.
DR Proteomes; UP000000874; Chromosome.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 46..322
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 334 AA; 36277 MW; A41A8530425E8624 CRC64;
MGVEEIPKET LLEIYRTMHK IRTYEETLAK WYYEGKSPRF DISAGPIPGE LHLSSGQESA
AVGVCVHLKD EDAVMGTHRA HHFAIAKGVD LKKMTAEIFG KATGLSGGKG GHMHLFDAAK
NFSCSGIVGA SFPQAVGVGI AAKLKGEDYV AVAVGGDGAA NQGTFHEALN LAALWKLPVI
FLIEDNGWAI SVPKDKSTAV AKNSERAKAY GIPGVSVDGA DVIAVYEVAK EAVERARRGE
GPSLIEVRTY RLRGHFEGDP QLYRPKEDFE LAKEKDPLAN FRKLLLEKGI ATEEELARIE
EENEREVREA IDFALNSLYP EPEEALKGVF AGGE
//
