ID G0JP64_9PROT Unreviewed; 412 AA.
AC G0JP64;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=NAD-binding malic protein {ECO:0000313|EMBL:AEM47295.1};
GN ORFNames=Acife_1130 {ECO:0000313|EMBL:AEM47295.1};
OS Acidithiobacillus ferrivorans SS3.
OC Bacteria; Pseudomonadota; Acidithiobacillia; Acidithiobacillales;
OC Acidithiobacillaceae; Acidithiobacillus.
OX NCBI_TaxID=743299 {ECO:0000313|EMBL:AEM47295.1, ECO:0000313|Proteomes:UP000009220};
RN [1] {ECO:0000313|EMBL:AEM47295.1, ECO:0000313|Proteomes:UP000009220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS3 {ECO:0000313|EMBL:AEM47295.1,
RC ECO:0000313|Proteomes:UP000009220};
RX PubMed=21705598; DOI=10.1128/JB.05373-11;
RA Liljeqvist M., Valdes J., Holmes D.S., Dopson M.;
RT "Draft genome of the psychrotolerant acidophile Acidithiobacillus
RT ferrivorans SS3.";
RL J. Bacteriol. 193:4304-4305(2011).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; CP002985; AEM47295.1; -; Genomic_DNA.
DR RefSeq; WP_014028552.1; NC_015942.1.
DR AlphaFoldDB; G0JP64; -.
DR STRING; 743299.Acife_1130; -.
DR KEGG; afi:Acife_1130; -.
DR eggNOG; COG0281; Bacteria.
DR HOGENOM; CLU_034446_2_1_6; -.
DR Proteomes; UP000009220; Chromosome.
DR GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000009220}.
FT DOMAIN 23..156
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 168..405
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
SQ SEQUENCE 412 AA; 43585 MW; 7B780629E496FD56 CRC64;
MTETDAQADL WRRALEYHAR TPAGKLSVIP SKPCSSQEDL SLAYTPGVAA PVREIAADPN
KAYDYTAKGN LVAVVSNGTA VLGLGNVGPL AGKPVMEGKA LLFKRFADID AFDIEVQARD
AGHLIDVVAA IAPGFGGINL EDIAAPVCFE VEETLQTMLD IPVFHDDQHG TAVIVAAALQ
NALELQGKEL GRIKVAIVGA GAAGIAIARM LRALGVADIF LSDLHGVLHS GRRDLTQWHK
PLAVAPQDWD LAAMLRGADV VIGVSVRGAI PEAALPMLAP KPVIFALANP DPEIDPAVVR
RLRPDAIIAT GRSDMPNQVN NVLGFPFLFR GALDCRARQI NQPMLLAAVD ALARLAREPV
PDAVQAAYGL TATQGLAFGP EYIIPKPLDP RLRQRVSGAV TVAARESGVA RR
//
