ID G0L2J6_ZOBGA Unreviewed; 587 AA.
AC G0L2J6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Phenylalanine 4-monooxygenase {ECO:0000313|EMBL:CAZ95027.1};
DE EC=1.14.16.1 {ECO:0000313|EMBL:CAZ95027.1};
GN Name=phhA {ECO:0000313|EMBL:CAZ95027.1};
GN OrderedLocusNames=zobellia_969 {ECO:0000313|EMBL:CAZ95027.1};
OS Zobellia galactanivorans (strain DSM 12802 / CCUG 47099 / CIP 106680 /
OS NCIMB 13871 / Dsij).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Zobellia.
OX NCBI_TaxID=63186 {ECO:0000313|EMBL:CAZ95027.1, ECO:0000313|Proteomes:UP000008898};
RN [1] {ECO:0000313|Proteomes:UP000008898}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12802 / CCUG 47099 / CIP 106680 / NCIMB 13871 / Dsij
RC {ECO:0000313|Proteomes:UP000008898};
RG Genoscope - CEA;
RT "Complete genome sequence of Zobellia galactanivorans Dsij.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAZ95027.1, ECO:0000313|Proteomes:UP000008898}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12802 / CCUG 47099 / CIP 106680 / NCIMB 13871 / Dsij
RC {ECO:0000313|Proteomes:UP000008898};
RX PubMed=22513138; DOI=10.1111/j.1462-2920.2012.02751.x;
RA Thomas F., Barbeyron T., Tonon T., Genicot S., Czjzek M., Michel G.;
RT "Characterization of the first alginolytic operons in a marine bacterium:
RT from their emergence in marine Flavobacteriia to their independent
RT transfers to marine Proteobacteria and human gut Bacteroides.";
RL Environ. Microbiol. 14:2379-2394(2012).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR EMBL; FP476056; CAZ95027.1; -; Genomic_DNA.
DR RefSeq; WP_013992339.1; NC_015844.1.
DR AlphaFoldDB; G0L2J6; -.
DR STRING; 63186.ZOBELLIA_969; -.
DR KEGG; zga:ZOBELLIA_969; -.
DR PATRIC; fig|63186.3.peg.954; -.
DR HOGENOM; CLU_034458_0_0_10; -.
DR OrthoDB; 9780502at2; -.
DR Proteomes; UP000008898; Chromosome.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004505; F:phenylalanine 4-monooxygenase activity; IEA:UniProtKB-EC.
DR CDD; cd00361; arom_aa_hydroxylase; 1.
DR Gene3D; 1.20.58.690; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:CAZ95027.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAZ95027.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008898}.
FT DOMAIN 1..340
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 129
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 134
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 219
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 587 AA; 65970 MW; 6640F98B1F69488A CRC64;
MKYISNPVLD KLPAHLQQYI KPQDYNGYSA IDQAVWRYVM RKNVDYLSKM AHASYLEGLK
KTGISIDHIP NMYGMNRILK EIGWAAVAVD GFIPPSAFME FQAYNVLVIA SDIRQLDHIE
YTPAPDIIHE GAGHAPIIAN PEYAEYLRRF GEIGCKAISN AKDYELYEAV RHLSIIKEAP
GTPQEEIDKA EKHIEDLQNN MGEPSEIALI RNLHWWTVEY GLIGTPENPK IYGAGLLSSI
GESAWCMTDK VKKIPYSIDA AYTSFDITQP QPQLFVTPDF AYLSQVLEEF ANTMALRRGG
LKGIQKLIES KELGTIELST GLQISGNFDS VIEHEGKPAF FQTVGPTALS FREKELVGHS
TKQHATGFGS PIGKLKGINL AIEDMSPLDL KAYNIFEGQQ VSLEFEGHIK VSGEIITGTR
NLQGEIILVT FKNCRVSHKD KVLFESNDEL YNMAVGREIV SAFNGPADLN SFDLVTHKVS
SSTIKVKADS AQSKLEQYYE QIRHFREGKN ITISRHKVFE AIRDDYPNDW LLPVELYELA
KENGDNDFAQ EIAAHLETVK LNHPKLGHLI DDGLNLVNHK FETEKLK
//
