ID G0M6L3_CAEBE Unreviewed; 700 AA.
AC G0M6L3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=CBN-CTBP-1 protein {ECO:0000313|EMBL:EGT30483.1};
GN Name=Cbn-ctbp-1 {ECO:0000313|EMBL:EGT30483.1};
GN ORFNames=CAEBREN_17931 {ECO:0000313|EMBL:EGT30483.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL379786; EGT30483.1; -; Genomic_DNA.
DR AlphaFoldDB; G0M6L3; -.
DR STRING; 135651.G0M6L3; -.
DR EnsemblMetazoa; CBN17931.1; CBN17931.1; WBGene00156656.
DR eggNOG; KOG0067; Eukaryota.
DR HOGENOM; CLU_016243_0_0_1; -.
DR InParanoid; G0M6L3; -.
DR OMA; IAVCHAP; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblMetazoa.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:EnsemblMetazoa.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblMetazoa.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR CDD; cd05299; CtBP_dh; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR043322; CtBP.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006612; THAP_Znf.
DR PANTHER; PTHR46029; C-TERMINAL-BINDING PROTEIN; 1.
DR PANTHER; PTHR46029:SF7; C-TERMINAL-BINDING PROTEIN; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS50950; ZF_THAP; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00309};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00309};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00309};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00309}.
FT DOMAIN 1..85
FT /note="THAP-type"
FT /evidence="ECO:0000259|PROSITE:PS50950"
FT REGION 61..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..653
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 76382 MW; 4EBE3AC9A04BCC93 CRC64;
MPTTCGFPNC KFRSRYRGLE DNRHFYRIPK RPLVLRQRWL TAIGRTEETV VSQVDKQIKI
ELPPKESKNS DRRRKQNIPA SPSRYRLIAM GGESNGTKPT GSQKRKRNPS QSPQTPHPPV
IADPQQALND ILSMTNPRMN GPSSSRPLVA LLDGRDCSVE MPILKDVATV AFCDAQSTQE
IHEKVLNEAV AALMYHSIKL EKEDLEKFKL LKVVFRIGYG IDNIDVKAAT DLGIAVCHAP
GDYVEDVADS TLSLILDLFR RTYWHAKSYS ETRKTIGADQ VRENAAGSKR VRGSVLGILG
CGNVGTAVGL RAKAFGLHVI FYDPFVRDGH DKAVGFERVF TMDEFMSRSD CISLHCNLGD
ETRGIINAET LRQCKPGVYI VNTSHAGLIN ENDLAAALKS GHVKGAALDV HDSVRFDPNC
LNPLIGCPNV INTPHCAWMT ESACKELRVQ AAKEIRKAIN GRCPQDLTHC INKEAVMRNT
NPVNRRTSAA ASHPLLNMGF PGLPNFPQMS MSPHFPYPNP LLAMGAQMGA LNPFMGNGGL
PFNPAAALSS LAAAQAANAQ RGSPANRSSR SSPSPHTNKS SVSPGNGNNG VVKTEPSSPT
PKIEVEIGEN EKRSMMTFLQ RLIGPNGNNS SSSTADSGNE SGDKEKAQSD GDENIEDMEV
IDAEKLKEEL NIGQLDEPEE ISVGLNNGNR INIDEQPIVT
//
