ID G0M6R5_CAEBE Unreviewed; 2570 AA.
AC G0M6R5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=CBN-HUM-4 protein {ECO:0000313|EMBL:EGT30557.1};
GN Name=Cbn-hum-4 {ECO:0000313|EMBL:EGT30557.1};
GN ORFNames=CAEBREN_05244 {ECO:0000313|EMBL:EGT30557.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; GL379786; EGT30557.1; -; Genomic_DNA.
DR STRING; 135651.G0M6R5; -.
DR EnsemblMetazoa; CBN05244.1; CBN05244.1; WBGene00143969.
DR eggNOG; KOG4229; Eukaryota.
DR HOGENOM; CLU_000192_14_0_1; -.
DR InParanoid; G0M6R5; -.
DR OMA; YITREST; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:EnsemblMetazoa.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd14874; MYSc_Myo12; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF26; MYTH4 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..652
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 800..949
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1963..2028
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2093..2248
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 2254..2563
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 530..552
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1046..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1536..1555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1565..1595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1686..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1377..1405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1721
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 83..90
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2570 AA; 295786 MW; 55AEF9CE5B35F300 CRC64;
MENLIEIPDQ SEAGIAQNLH ERFKKGELYT KASNVLVFVN DYNKTSNQDQ QGFKKCHVTG
MAKNALDKII SMSSNAETIV FSGESGSGKS HNAFNVFKFL TSEPKSKVTT KHSNAIESVF
KSFGSAKTLK NDEATRFGCS MDLLYKRNIL TGLNLKYTVP LEVPRVISQK PGERNFNVFY
EIYHGLNDEM KAKFGIKGLQ KFFYINQGNS TENIQSDVNH FKSLEDALHS LGFSDDHCIS
IYKVISTILH IGNIYFRTKR NPNVEHDVVE IGNMSEVKWV AFLLEVDIDQ LVNFLLPKSE
DGTTIDLNSA LDNRDSFAML VYEELFKWIL SRIGLHLKCP LHTGVISIID QYGFEKYNNN
GVEEFLINSV NERLENLFVK HNFHDPLVDY AKDGITVDYK VPNSIENGKT VELLFKKPYG
LLPLLTDECK FPKGSHESYL EHCNLNHTDR SSYGKARSKE RMEFGVRHCI GTTWYTVTDF
FSRNKRLVSL AAVKLLRSSK NPIIGLLVES YSANTNDMIV SQAQFILRGA QEIAEKINGS
HAHFVRCIKS NNERQPKKFD IPLVNRQIKN LLLAELLSFR LQGYPVRMSK TTFARKYRCL
LPGDIAMCQN EKEIIQDILQ GQGVKYENDF KIGTEYVFLR ERLADRYENQ QNKICSEAAI
VIQKNLKSFV AQKIYKRKRA AIIKLQAGLR GWKARKDYIA KREEMFKAIG RTMKRNKRLD
AYHQALGGDG SNQLQHTLVG YIDINEDAKK ALERPTSDSE ATETLTQYLT VPVKNFLPNM
KSISLEEYAE ENFKGHLLEP RREPIMTPFL HKESEFDFRL SVEIFKMILK YMNDRKLSRK
QREDLGRYIV QQGISNPCQR DEILVQIINQ IHKNPDKTAT DHGWKLVHMA ISVFPPTENI
IPMLIGFFNQ EAAPLREQLF STLQRRLKIY DSEIARELPP SNLELQATPN IPNTIAEINC
YDGLSYDLHL SPWSTTSELA ERILKQRGVG IALGWTVEVE TPNRVFVPTG NHFIHDVFSQ
IEGSKIDTET PHKIFFNFPP EKLVKKAPAE QKPVVEPIEE TATPKLPRHY PTPEEWSKQP
PRVESRNTPQ DHQKQDDESD ESLLREYNEE AGYAYTLPRK NKAKQQDSEG NETSESEDDV
GDDADNRVEY ESVRPQENMK STETIQDHSH ILKSPILPRK TYSRNEHHEE YTPMNFAPPP
TFTYPQQMPM MQYVPVMMTP SMIPGQQIAM IPQQMMMQPQ FSYVPQYPQI PQYRPPEPIL
SPQSVRSDVP PMMAPVMYDG HESTRSRDFR KMKRGEVPSQ YSTIRNMPVP EHGKDVDQFL
DAVFDQCLSK DERRAAEFNS QQLASTIKGG RVRPEGYYEP PQQTYSPVPP RYPTLRRVDD
SPVRSRAKSL PRILSPRHDH YIRNTHSRNS YSNESTSSDD QMNYRTRSRE RSLPRFHSNN
GYNYDPNQPV YMMPVQMNGH GEMILLSPVG SEQRAQIKNG THDRSRRHHA TSGVERYMAK
RSPSVDMLKP HKSRRTPDIM LEQTHVRPHL AQSPVGRHTG RIEEFSLPRG DSRTREKMEN
PLLARQYQRT NPYQNGYVVP PPPSSYRSPS PAPTAGDRKV NFLEFFVSQN FIQGLSRLPQ
EAYVEPAVKN TKNNSEYLSP HRFNLDEQKA VIRHEKETAK NALNMLSNQL RKLPPPVDNV
RLIRPVTPSQ RPITPAPVPS EPQIVQTPSP PPQPTPPQPA PIRQEWVVRD SVERKPETQE
RIRGSFIKEP LVPQPPRAPV VAEKPAVKFV KAPWKLTIRK EMFYPGEVLN DIQIIDQVFA
QIVEDCKKSY PYRIRLEDRK QVEDILRHYE VPPSDLNNQS NIHPDVKVAI IEKARLWPLY
FNQIYEVIEK RPDESVSIIF AISEHGIRLL VHTPHDLEHP LKIQDYFPFE TIADVSLEAN
DILSVHVRHE NEENAYSAVR IKTNQAPQIK KTLEKCLSGG VVPKRKFVRA LEDYVTSEVN
HLSFKQGDVI ELLPVPEAET PPVGNWLYGR IENRFGFLLA QYVDSANGDM VPPIRYENSA
GRDERVKFFD DEVPFSSERY TMLDFATKYF RKPKDKKKQE EWAWEDISQA VRYSDRGISQ
SLLADLGSEE SKYAVETFHS IMKFMGDEPL KKSESMTDVV FKVLIICHRH PTLRDEVYCQ
LIKQTTSNTS TKPNSALRAW RLLTIITAYF PSSLTLKPYI LQYLGDNADD WQRPYHGTAR
ICQTNMIQTF KYGGRKVLLN ALEVQQITDG CQLRRQAFYI SREHSVSQTL RPITVAEEMI
QELCSLLNVR SLHEQQEFSL CYTIGKDKRV NYCKNDNYLM DIITESEHKK LPFQFHLKRT
VWVHPLRYDN AAYIDSMFDQ VIDDYLRGSL ISTNSLGQLT AATTEEIIKL AAYLFLLLPD
NPKGLTAKIL PQIVPKSVIE PKHRHQEEMV TRINRQLKMF GGRMRPAEAK SHFLELLSTW
PSFGVLHYRL KSVVENGNQL PEVILTINKS GIQLLQPKSK EVFKQRNYDQ IESVESIRKT
AYKIVRLVIN TPEGEETLDI KTDEADEISH LIGQYMFVTC GIEDRGSTEL
//
