ID G0MF05_CAEBE Unreviewed; 474 AA.
AC G0MF05;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=dUTP diphosphatase {ECO:0000256|ARBA:ARBA00012379};
DE EC=3.6.1.23 {ECO:0000256|ARBA:ARBA00012379};
GN ORFNames=CAEBREN_12068 {ECO:0000313|EMBL:EGT54310.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP
CC route): step 2/2. {ECO:0000256|ARBA:ARBA00005142}.
CC -!- SIMILARITY: Belongs to the dUTPase family.
CC {ECO:0000256|ARBA:ARBA00006581}.
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DR EMBL; GL379792; EGT54310.1; -; Genomic_DNA.
DR AlphaFoldDB; G0MF05; -.
DR STRING; 135651.G0MF05; -.
DR EnsemblMetazoa; CBN12068.1; CBN12068.1; WBGene00150793.
DR eggNOG; KOG3370; Eukaryota.
DR HOGENOM; CLU_043990_0_0_1; -.
DR InParanoid; G0MF05; -.
DR OMA; MELPFGY; -.
DR UniPathway; UPA00610; UER00666.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0004170; F:dUTP diphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006226; P:dUMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0046081; P:dUTP catabolic process; IEA:InterPro.
DR CDD; cd07557; trimeric_dUTPase; 3.
DR Gene3D; 2.70.40.10; -; 3.
DR InterPro; IPR008181; dUTPase.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR033704; dUTPase_trimeric.
DR NCBIfam; TIGR00576; dut; 3.
DR PANTHER; PTHR11241; DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE; 1.
DR PANTHER; PTHR11241:SF0; DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE; 1.
DR Pfam; PF00692; dUTPase; 3.
DR SUPFAM; SSF51283; dUTPase-like; 3.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068}.
FT DOMAIN 23..151
FT /note="dUTPase-like"
FT /evidence="ECO:0000259|Pfam:PF00692"
FT DOMAIN 182..309
FT /note="dUTPase-like"
FT /evidence="ECO:0000259|Pfam:PF00692"
FT DOMAIN 345..473
FT /note="dUTPase-like"
FT /evidence="ECO:0000259|Pfam:PF00692"
FT REGION 142..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 51234 MW; 6CEC1338395DEF52 CRC64;
MAKTETTATS TRLTVRFTEL NENARMPTYG SASAAGADLH SAEDVVVPAK GKLCVSTGIQ
IELPVGYYGR VAPRSGLAAK HFIDVGAGVI DSDYRGEVKV LLFNFNDTDF EVKKGDRIAQ
LICEQIGMGT FEEVESLEST ERGAGGFGST GQSTMTSETE VKAADDDEKR IPVRFTLLNK
DAEALRYASR QAAGADFYST EEVVIPAHGK FCVSTGVQVE LPFGYYGRVA PRSGLAAKQF
IDVGAGVIDS DYRGEVKVLL FNFNDTDFEV KKGDRVAQMI CEKIGHCVYV PASELENTDR
GAGGFGSTGE NIMEKEEPLV KKSKIEQAEA RPKSVTIQFT KKNENAEKPT YGSDLAAGAD
LYSCETATVP AKGKWLVSTG IHMKLPYGYY GRVAPRSGLA AKHFIDVGAG VIDSDYRGEV
KVLLFNFGDA DFEVKKGDRI AQLILEQIAH CRYEQVDSLE DTERGAGGFG STGK
//
