ID G0MFY3_CAEBE Unreviewed; 1633 AA.
AC G0MFY3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=CAEBREN_32751 {ECO:0000313|EMBL:EGT54381.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR EMBL; GL379792; EGT54381.1; -; Genomic_DNA.
DR STRING; 135651.G0MFY3; -.
DR EnsemblMetazoa; CBN32751.1; CBN32751.1; WBGene00194942.
DR eggNOG; KOG0987; Eukaryota.
DR HOGENOM; CLU_001324_0_3_1; -.
DR InParanoid; G0MFY3; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR45786:SF82; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR45786; DNA BINDING PROTEIN-LIKE; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068}.
FT DOMAIN 556..734
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT DOMAIN 1480..1525
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
FT REGION 1..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1633 AA; 185247 MW; 98BBF778B89DB246 CRC64;
MVKSTPKQPP STLSSWTGRL RTRTVKTNSQ QAMTTSSRPD SIPVERRRPD AEKSTERQVV
APSNTPKANP VKRSEHARLT AKKTAEALRK ALNRLHESED VKKKRKTVNA ARTAKTRSEE
TANDRRRRLS LNKAQTSRAR AKETDEVTAA RRASNAASTS RSRAKESDEA AAARRSSNQC
RTARARSKES DECATARRAL DAANKSRARS EESDTVKAER QKQDAHRKAI TRSQESQETS
DARRSADRQR HAAPTNQQQY LGLAKRDAPV KEHYLGQMST QCSSCKALHY QGELPQSKEF
NTCCRHGLVD LPMFENFPPE LQDLYVGSTP EANEFRKNCR SYNNSLAMGC TKAKLDVPKG
GPYSFRIHGQ VYHLIGPLHP AEGEEHVFAQ VFILDTEEAA DELANRKVNR TCSKEVFKLL
IDILEKYNPF VKSFKMMREK EEEEEMMAKA QNRELKEVKM VFRQGKKFDP NRYQIPTANE
VAVVFVGDEY QIPGRREITV YQRSTGKLQN LLDIDKETDP LCYPLLFVDG RYGWHLGRKR
RKESGDGEEK MSTREFYSYY LHVRPQFSPL FYAKKLFQQY CVDVWTKIEH ERLNFILKNQ
KQLRVESLHG LMEHVSGEEG GPCGQRIFLP SSFSGSPRDM VAQFQDALAI VSKFGKPDLF
ITLTSNPHWK EIEEALISGQ SAIDRPDIIA RVFKLKVDEV KKDIFVRKVY GEVAAWVYVV
EFQKRGLPHI HMLIILKDKW KLKTAADIDS IISAELPDKD EDPELFELVS TMMLHRPCGA
YNPEASCMVN GVCTKRYPKE FCEVTTVGAD GFTKYRRRND GRTVRVKLAN GDFVDLDNRS
VVPYNKYMIR KYRCHGNVER CGHVGAAKYL FKYVYKGHTR AAVRIFTDSS GAKHQQENEI
DSYLDTRYLC APEALHRIYG FKMSDRSTPV MQLKVHVKDA QGVVFQAGQE KNALESAKMR
KTTLTAWFAA NQRCAEELQN NGMIPADIVD SRGIHYIDMP EHFQFVKGEW VHRRQATKSI
GRMHFVSPRE QERFALRLML LNTVDATSYE NLLTVDGHQY ENFVEAAKAA GYLTDDSFYE
KSLEEATTFQ TGSQFRSFFA TLLLFGEIHN AEILWNKFRN EFSEDFSLHY PQQMAETLAY
NDLIDRMNAM GENLEKWMKL DYDRVTPEDF VDYDFCRQEG QRMREKLSAE QEEIVRAALE
ALEQGGGLMY VDGPGGSGKT FVYNCLIHIL NGMQKKVASL AWVGIASALL PNGRTVASYF
HLNVKDGCKS SSLHLQSAEA KKLAELDGLV WDEAPMSPKA ALETVDQVLQ DVTGIKKPFG
GKLMILGGDF RQCLPVVHRG GIEEQVANSI KKSEKLWPLF KTYRLTRNLR VSDGNEEWKQ
FLLDVGDGKL GEGPSGLMDV PPELRSQGNL AEEMFGSLLR SQADASDISR VAILTPTNKG
ALEMNEKVFN MIPGNYRMYD SVDEVGEKEE SSDATNFPTE FLNKMSPAGL PPHRLKLKIG
AIVMLIRNLD VRNGLCNGSR MVVKQMGERV LGCELITGPR KGEAVLVPRI TLTYDTDIPF
VLKRNQFPIR PACAMTVNKA QGQTFDRIGV LLDNPIFSHG QLYVALSRTR TKEGVRISAP
DNVMNNIVFR NIL
//
