ID G0MLZ2_CAEBE Unreviewed; 743 AA.
AC G0MLZ2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=EGF-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAEBREN_28873 {ECO:0000313|EMBL:EGT36606.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; GL379801; EGT36606.1; -; Genomic_DNA.
DR AlphaFoldDB; G0MLZ2; -.
DR STRING; 135651.G0MLZ2; -.
DR EnsemblMetazoa; CBN28873.1; CBN28873.1; WBGene00190838.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_376087_0_0_1; -.
DR InParanoid; G0MLZ2; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF00058; Ldl_recept_b; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00192; LDLa; 2.
DR SMART; SM00135; LY; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
DR PROSITE; PS51120; LDLRB; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..743
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003404312"
FT DOMAIN 273..314
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 276..314
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 361..403
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 504..548
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 597..633
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 41..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..61
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 657..672
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 697..712
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 743 AA; 83085 MW; 41B2A113980CFF4E CRC64;
MKLLLKLLLV PILIDLPGII HTLSSHHYRN EDPIIINTTH SSMLPTTSAP PPPPSPSILN
KPEPSPCDLI EEAAALHCIG PLVDYAADLS NNVLHPPLSA VEMTCDKYNQ YMMCTQGVRP
DCRQSRAPNI EFMYETICEE KLAAIMKEEK TCLLEVENDK NVKECFVNKT NTLRDETPDT
VSTTQNYECT VIQAYVDCLI EREETTCRDA VKIEISFLSM LAKRNSEARC ELNTDATKAR
PKAQPLEECD TQGNCKCRLP GYYYEAARKK CLDVDECESL SSGCSQKCIN LPGSFECTCD
QRFYKLAADN KTCERIDQSP MWLFFAHGQS VWNISTDGKS FQLQRAGLQK TAMIDIDVKE
NRLYYADIGA NVIERMNIEG TFPQAVQRFD VDGLEGIAVD WIGRNLYSLR RLEGLKILKN
QIIFFREDVL VQSLDGRFRQ SVYRNVMKLP RSIALHPSKG IMFVTDWSAN AFIAAASMDG
SHFRKIITDR ITWPNAVAVD IFAEKIYWAD AFLDTIESCN MDGSARRIII ADAGSVPHVF
GLAIADDFLY WTDWTYRGIL RANKHSGENI TVLAQTALLP YSLKVFHKTL QPEQVSTCAS
RGCDQLCLLG ENGAATCACG EGFDLQIDGK TCRSNCSDSQ IECGGADPKC ISKIYLCDGL
AQCSNQADEL NCPPRICLPG QFQCHDNRKC LPPGGLCDEV ADCADSSDEM YCPHQTKNAR
GDFVLNSPSL RKERSVAEWD NFI
//
