ID G0MM29_CAEBE Unreviewed; 1098 AA.
AC G0MM29;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Peptidase M14 carboxypeptidase A domain-containing protein {ECO:0000259|PROSITE:PS00133};
GN ORFNames=CAEBREN_00188 {ECO:0000313|EMBL:EGT36562.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
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DR EMBL; GL379801; EGT36562.1; -; Genomic_DNA.
DR AlphaFoldDB; G0MM29; -.
DR STRING; 135651.G0MM29; -.
DR MEROPS; M14.A22; -.
DR EnsemblMetazoa; CBN00188.1; CBN00188.1; WBGene00138913.
DR eggNOG; KOG2650; Eukaryota.
DR HOGENOM; CLU_283599_0_0_1; -.
DR InParanoid; G0MM29; -.
DR OMA; DPREINC; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03860; M14_CP_A-B_like; 2.
DR Gene3D; 3.30.70.340; Metallocarboxypeptidase-like; 2.
DR Gene3D; 3.40.630.10; Zn peptidases; 2.
DR InterPro; IPR036990; M14A-like_propep.
DR InterPro; IPR003146; M14A_act_pep.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR11705:SF91; CARBOXYPEPTIDASE A1 (PANCREATIC)-RELATED; 1.
DR PANTHER; PTHR11705; PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B; 1.
DR Pfam; PF00246; Peptidase_M14; 2.
DR Pfam; PF02244; Propep_M14; 2.
DR PRINTS; PR00765; CRBOXYPTASEA.
DR SMART; SM00631; Zn_pept; 2.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 2.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 2.
DR PROSITE; PS00133; CARBOXYPEPT_ZN_2; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 774..784
FT /note="Peptidase M14 carboxypeptidase A"
FT /evidence="ECO:0000259|PROSITE:PS00133"
FT REGION 926..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1098 AA; 124871 MW; 33E939C1CD22A481 CRC64;
MCFDLIELNF WKTGKDKHGF WDVMVEMKNE KFFLDYLQLN DISHMKTIED VERLITKHEN
NQTLSKLFPR LWDDSSSAHY DFHTYGSYQR MTDWMKQLVQ KYPKMVQYIS IGKTTEGRNI
DGVEIGGDSR TKKIFWIDGG IHAREWAAPH TALFFIHQLT SRANEPGIKK LLEEITFVVV
PCLNPDGYEF TRSSTNPHVR LWRKNRSKMQ CRKDIWGRNR CCRGVDLNRN FDFHFRESGT
SDDPCSEIYQ GPAPFSEPEA KAVRDALLSQ RYRGRTDAYI TLHTYSQIWI HPYGHKKDAY
PGDIKDLYEV GKKAAQALKR VYGTKYVVGS GADTLYPASG GSEDWAKHEA KVKFVYLLEL
RPDEKNWDGF ILDEKELIPT ARETWEGVRV VAEAVLDRIL AGRASTPRGG HPQREEEKGE
KKRSLGVLTT LWSIFFCIRV CVCSSLVSDY CCTKMRYLLF LVLIFCDETV YGIHNTDENS
AFHNFKLIRI NPETEGSVRY LRSLYEDPSP YELDFWQPPT HIGAIVDLTV APSDAPRFVK
DLESKNINYI VAVNDLSKAI ENERGSDAFY NPVAGFAYDK YNSLDEIHSE MKRLKKEYPT
MITLIDIGQS HENRTLLVMK ITGKRNPLGS KISMWIDGGI HAREWISPAT AMYIAHELIL
GYENDATVAK LMDHIDFYIL PVMNPDGYEY SREKNRMWRK NRSPAKCHRQ TFSTVCCSGV
DLNRNFDWFW ASTGSSSDPC HDTYHGSSAF SEPESQAVRD FLEQNTPEAF ISLHSYSQMW
LIPYGHRKQS YPQDYHTGLR PLALRATKAL YELYGTKYQV GTGADLMYEA SGGSHDWAKG
QLKVPYAYLI ELRPKNTMMG HGFLLPEREI VPTGLETSES IKVVADELVA QFVEPVIRAK
MSTTSRPSIP PYRRGYSIID TTTTEPEDTV TEKRTTVVPS TVSTTTTVAP TTTTTVATTT
TTEEPTTTTP TTTTTTTEAP TTTTETTTVP PTTTTTVTES TTTTTVSQET TTTISPEDAT
ATVVLPTETY PPGTEEVSTI RPDEETEEIR VIEETSAPVK CLDYGDYCRL WGVLQLCYRD
QVSKLCPKTC DSRCAFVN
//
