ID   G0MP04_CAEBE            Unreviewed;       381 AA.
AC   G0MP04;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=Legumain {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CAEBREN_26195 {ECO:0000313|EMBL:EGT38953.1};
OS   Caenorhabditis brenneri (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN   [1] {ECO:0000313|Proteomes:UP000008068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG   Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C13 family.
CC       {ECO:0000256|ARBA:ARBA00009941}.
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DR   EMBL; GL379804; EGT38953.1; -; Genomic_DNA.
DR   AlphaFoldDB; G0MP04; -.
DR   STRING; 135651.G0MP04; -.
DR   MEROPS; C13.A02; -.
DR   EnsemblMetazoa; CBN26195.1; CBN26195.1; WBGene00164920.
DR   eggNOG; KOG1348; Eukaryota.
DR   HOGENOM; CLU_024160_0_0_1; -.
DR   InParanoid; G0MP04; -.
DR   OMA; TYCENDM; -.
DR   Proteomes; UP000008068; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR001096; Peptidase_C13.
DR   PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR12000:SF42; LEGUMAIN; 1.
DR   Pfam; PF01650; Peptidase_C13; 1.
DR   PIRSF; PIRSF019663; Legumain; 1.
DR   PRINTS; PR00776; HEMOGLOBNASE.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..381
FT                   /note="Legumain"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003403808"
FT   ACT_SITE        163
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT   ACT_SITE        204
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ   SEQUENCE   381 AA;  43351 MW;  8E2215F454DFB021 CRC64;
     MRQTFILLIL AVLALSAVLD ARLYPRKGLA AARARKHKYQ DEGEAFVVLV AGSNGWYNYR
     HQADVAHAYH TLRNHGIPEE NIITMMYDDV ANNQLNPYKG KLFNRPHGKD LYKGLKIDYK
     GASVTPENFL NVLKGNASAI DGGNGRVLET NEQDRVFVYF TDHGSVGMIS FPEGILTVKQ
     LNDALVWMHK NKKYSQLAFY LEACESGSMF ENVLRNDMDI YAISAANGHE SSWGTFCEND
     MNLPCLGDLF SVNWMTDSDG EDLKTETLEF QYELVKKETN LSHVMQFGDK EIAKEAVALF
     QGDKEDREYT EDFGLSASKS VNWPARDIEL NHLISQHKKS NDLAMSNKLE YKINRIRETR
     RAIKKNVHMI VDKLFEGESE E
//