ID G0MPB6_CAEBE Unreviewed; 515 AA.
AC G0MPB6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=asparaginase {ECO:0000256|ARBA:ARBA00012920};
DE EC=3.5.1.1 {ECO:0000256|ARBA:ARBA00012920};
GN ORFNames=CAEBREN_28810 {ECO:0000313|EMBL:EGT38922.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL379804; EGT38922.1; -; Genomic_DNA.
DR AlphaFoldDB; G0MPB6; -.
DR STRING; 135651.G0MPB6; -.
DR EnsemblMetazoa; CBN28810.1; CBN28810.1; WBGene00190775.
DR eggNOG; KOG0503; Eukaryota.
DR HOGENOM; CLU_019134_3_0_1; -.
DR InParanoid; G0MPB6; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0004067; F:asparaginase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009066; P:aspartate family amino acid metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.40; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.1170; L-asparaginase, N-terminal domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036152; Asp/glu_Ase-like_sf.
DR InterPro; IPR006034; Asparaginase/glutaminase-like.
DR InterPro; IPR027473; L-asparaginase_C.
DR InterPro; IPR027474; L-asparaginase_N.
DR InterPro; IPR037152; L-asparaginase_N_sf.
DR PANTHER; PTHR11707:SF28; 60 KDA LYSOPHOSPHOLIPASE; 1.
DR PANTHER; PTHR11707; L-ASPARAGINASE; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00710; Asparaginase; 1.
DR PIRSF; PIRSF001220; L-ASNase_gatD; 4.
DR PIRSF; PIRSF500176; L_ASNase; 4.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF53774; Glutaminase/Asparaginase; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS51732; ASN_GLN_ASE_3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068}.
FT DOMAIN 95..200
FT /note="L-asparaginase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00710"
FT REPEAT 328..360
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 443..475
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT ACT_SITE 104
FT /note="O-isoaspartyl threonine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001220-1"
SQ SEQUENCE 515 AA; 57315 MW; A13387E91F9D2C18 CRC64;
MSIDGATCPP INIRRCSCTS EGFSPKKSIT SPNFERRASK ILDENHLPKQ LLVQHHHEDG
AFLRNISATE LVLEVDETAH GAQQIGAPSA LPESRVLVLY TGGTIGMKTT DGVYCPVPGY
LPEVLRDIPP LNDRRYVEEI YSNTAVRPYS LPPVRNMKKR VVYWIVEYEP LLDSCDMTFD
DWIRIATDFK KAYHKYDGFV GQVDVNYATG KILYDIGVIP GSDMTSEAAM AKLCYVLGKD
EWDLPMKRSM LQANLRGEMT VATKGAMREL DIIPHIAKCL RVSSSQEVQL LRDIILPPMF
CNAAKTNDVE ILKSLKAAGV NFSATDYNLR TALHVAASNG NIESVNYLLK IGTNVHIKLV
LDFELHSILK CFFRDMFGYN ALVCAVKAKA MNCIIAIREA GGFIDASSQK IGVELCLAVY
QNDIELLKCN EAAGIHMGEK DYDNRTALHV AVSLNKPEMV AYLLQCGLSP YEKDNFGITP
IDEAKRRHLN TLIDMMEAAH QPESPESTSG VFHMD
//
