ID G0MVF5_CAEBE Unreviewed; 479 AA.
AC G0MVF5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial {ECO:0000256|ARBA:ARBA00022402, ECO:0000256|RuleBase:RU364066};
DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU364066};
GN Name=Cbn-nuo-1 {ECO:0000313|EMBL:EGT44910.1};
GN ORFNames=CAEBREN_15441 {ECO:0000313|EMBL:EGT44910.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000256|RuleBase:RU364066}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00043775};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29092;
CC Evidence={ECO:0000256|ARBA:ARBA00043775};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917,
CC ECO:0000256|RuleBase:RU364066};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966,
CC ECO:0000256|RuleBase:RU364066};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|RuleBase:RU364066}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU364066}; Matrix side
CC {ECO:0000256|RuleBase:RU364066}.
CC -!- SIMILARITY: Belongs to the complex I 51 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00007523, ECO:0000256|RuleBase:RU364066}.
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DR EMBL; GL379814; EGT44910.1; -; Genomic_DNA.
DR AlphaFoldDB; G0MVF5; -.
DR STRING; 135651.G0MVF5; -.
DR EnsemblMetazoa; CBN15441.1; CBN15441.1; WBGene00154166.
DR eggNOG; KOG2658; Eukaryota.
DR HOGENOM; CLU_014881_1_2_1; -.
DR InParanoid; G0MVF5; -.
DR OMA; KWQFIPQ; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045271; C:respiratory chain complex I; IEA:UniProt.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0043054; P:dauer exit; IEA:EnsemblMetazoa.
DR GO; GO:0030421; P:defecation; IEA:EnsemblMetazoa.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR GO; GO:0048598; P:embryonic morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0008406; P:gonad development; IEA:EnsemblMetazoa.
DR GO; GO:0040039; P:inductive cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:EnsemblMetazoa.
DR GO; GO:0033108; P:mitochondrial respiratory chain complex assembly; IEA:EnsemblMetazoa.
DR GO; GO:0043050; P:nematode pharyngeal pumping; IEA:EnsemblMetazoa.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:EnsemblMetazoa.
DR Gene3D; 3.10.20.600; -; 1.
DR Gene3D; 3.40.50.11540; NADH-ubiquinone oxidoreductase 51kDa subunit; 1.
DR Gene3D; 1.20.1440.230; NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain; 1.
DR InterPro; IPR001949; NADH-UbQ_OxRdtase_51kDa_CS.
DR InterPro; IPR011537; NADH-UbQ_OxRdtase_suF.
DR InterPro; IPR011538; Nuo51_FMN-bd.
DR InterPro; IPR037225; Nuo51_FMN-bd_sf.
DR InterPro; IPR019575; Nuop51_4Fe4S-bd.
DR InterPro; IPR037207; Nuop51_4Fe4S-bd_sf.
DR NCBIfam; TIGR01959; nuoF_fam; 1.
DR PANTHER; PTHR11780:SF10; NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11780; NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1; 1.
DR Pfam; PF01512; Complex1_51K; 1.
DR Pfam; PF10589; NADH_4Fe-4S; 1.
DR SMART; SM00928; NADH_4Fe-4S; 1.
DR SUPFAM; SSF142019; Nqo1 FMN-binding domain-like; 1.
DR SUPFAM; SSF142984; Nqo1 middle domain-like; 1.
DR SUPFAM; SSF140490; Nqo1C-terminal domain-like; 1.
DR PROSITE; PS00644; COMPLEX1_51K_1; 1.
DR PROSITE; PS00645; COMPLEX1_51K_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|RuleBase:RU364066};
KW Electron transport {ECO:0000256|RuleBase:RU364066};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU364066};
KW FMN {ECO:0000256|ARBA:ARBA00022643, ECO:0000256|RuleBase:RU364066};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU364066};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU364066};
KW Membrane {ECO:0000256|RuleBase:RU364066};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU364066};
KW Mitochondrion {ECO:0000256|RuleBase:RU364066};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU364066};
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU364066};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Respiratory chain {ECO:0000256|RuleBase:RU364066};
KW Transit peptide {ECO:0000256|RuleBase:RU364066};
KW Transport {ECO:0000256|RuleBase:RU364066}.
FT DOMAIN 375..420
FT /note="NADH-ubiquinone oxidoreductase 51kDa subunit iron-
FT sulphur binding"
FT /evidence="ECO:0000259|SMART:SM00928"
SQ SEQUENCE 479 AA; 52495 MW; D94E5305B092AE5E CRC64;
MASAAVSLGA RLIGQKVPKV AVRGVVTSAQ NANAQVKQEK TSFGNLKDSD RIFTNLYGRH
DYRLKGALSR GDWYKTKEII LKGSDWILGE LKTSGLRGRG GAGFPSGMKW GFMNKPFDGR
PKYLVVNADE GEPGTCKDRE IMRHDPHKLI EGCLIGGVAM GARAAYIYIR GEFYNEACIL
QEAINEAYKA GYLGKDCLGT GYNFDVFVHR GAGAYICGEE TALIESLEGK QGKPRLKPPF
PADIGLFGCP TTVTNVETVA VAPTICRRGG DWFASFGRER NRGTKLFCIS GQVNNPCTVE
EEMSVPLKDL IERHCGGVIG GWDNLLAIIP GGSSVPLMPK NVCDTVLMDF DALVAAQSGL
GTAAVIVMNK QTDIVKCIAR LSLFYKHESC GQCTPCREGC NWLNKMMWRF VDGKAKPSEI
DMMWELSKQI EGHTICALGD AAAWPVQGLI RHFRPELERR MAEFHKQVLA EQGAKQISQ
//
