ID   G0N3D1_CAEBE            Unreviewed;      1492 AA.
AC   G0N3D1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Tyrosine-protein phosphatase domain-containing protein {ECO:0000259|PROSITE:PS50055};
GN   ORFNames=CAEBREN_20794 {ECO:0000313|EMBL:EGT51550.1};
OS   Caenorhabditis brenneri (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN   [1] {ECO:0000313|Proteomes:UP000008068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG   Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GL379834; EGT51550.1; -; Genomic_DNA.
DR   STRING; 135651.G0N3D1; -.
DR   EnsemblMetazoa; CBN20794.1; CBN20794.1; WBGene00159519.
DR   eggNOG; ENOG502QQEE; Eukaryota.
DR   HOGENOM; CLU_003777_0_0_1; -.
DR   InParanoid; G0N3D1; -.
DR   Proteomes; UP000008068; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   CDD; cd12087; TM_EGFR-like; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR003125; WSN.
DR   PANTHER; PTHR32525; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR   PANTHER; PTHR32525:SF3; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR   Pfam; PF02206; WSN; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SMART; SM00453; WSN; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        837..858
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          999..1265
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          866..999
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1330..1492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        879..919
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        921..945
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1330..1393
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1452..1478
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1492 AA;  166516 MW;  15AF58AC4D710E95 CRC64;
     MAERSSTRVR KRSRKSHRRN EPRLPPTNFS KLWIWALVLF VSAQQVFSAG LLRQEFNGAN
     STGDGSRMAA ARFRRETIKL DNAITNLGYL ARIANGIALE IGLVDGTIDP GEAVAELLHM
     GSLKVDDVIN LNQENIDNVL NALGDKTSAE DAVIKAEDWL DNLEELREMA PKFGDLEKIP
     GLEKFKEAFE KVKVLVGSKT DLDKLTERVD EIHGALMKLE KAVKETLDQQ VIDESEPRMK
     SVAVIMKSVK SSENLFNSLT NNVMEARKIL DESNLMKTLQ EEAKLRKNLN IDYKKGFDKL
     TKNFEKVNDA SKKASTAEKD FESIQKLSDS RKHSHRQLFK VSSGFPEGPA DLRKLYSESV
     DPRVVKQISD GETVTESLKQ GFESFKKLEE SLADVSFKWK SLANSPSEFE KALNRAFQLA
     SLSKSYVTAS EVVNNLKLCE GDIKTPPSHD TTELKELDTK MSLLTKISDF SHINELRKTP
     MTDFDVDEGK TSDERKAFVE ALLGKWNKDE KLKKFVANVN SLHEDLSHLK KLVDYVSRNS
     DLKSLTKYFD ATFKDQKYEQ FLTCLRNITA DGYPVKELIE YLRDSRKSSS YSVVISTIHE
     VIESGKSLKT AETAAESFSK NTALPPQVAL LKSSFDKDGY KETSEKLGMG VQGLIAIKRV
     REAKLETLLK DVNDILKDAG EKGLSPEQQS SLKQLKEIPK VVTSIDNFMK SSTGLQAFRR
     RRDTGFKDFH QIFMDAQAIQ GVSIDMKSLR DAMEKLDKVT NQKHATSMVE LKNLEALDLD
     FSKFNFKDVP TSLNALDVFF FNYALQLSES PSSSGQQDPS FDGLVETTTA GGDGTSLVII
     IGGSLLFLVV IALIIWLIRT FLCKPKPPPP TPTPIPDDES DSNSHEKEDK KGGKDPNGGK
     KDDDDGGSKE NKGKKSEDPK PPPSAGGPGP TPPPPPPPPT DQGNAPPPGT SNDQAGAPSV
     HSELPSGDPK REAPSAPSLP EQLISETRTK KLVHKEPELP VSNEESLALV KTSAAQIREA
     AKEGISPKGW AKAICEQPLG VYERMTSEER EAMRFVAQGP FDETEEGRRE TCGKHHAMIH
     KYKITSIIQL CQNEEEEDKM AGKVEKVKKS GEYYYDYEGG RGAYNNGYWM KTKKIIDGPI
     RFTDKKNFTL FNLQSITCDE LLNEIKRDLD LLLYKGWPDH SVPKTTDATL EILDFAEGPL
     NLLITSHTGT GRAGTLASII YGIDMCQRMV VNDPKEFIKK VREIRYGAVR EDVQLTFLIL
     CITKSIMKER GIEFCKELHE MEWYHRRCLE EKNAGGYEHT AELLLEDQAK MDAHVQQLEE
     EYLRKKHIED ERQKAEDAKN AEENEKVKAE SEDNREENNK SNDTKSTTKQ KSDGKKPSTS
     SDVKKDSEGE EKNSKASSVS SGSKNKSKKS EKNSKASVAS GGSQKKSKKS QKDSKKKAKT
     TAVPSGSQEK LKKKSTNGEE KKSEEKKKPS VVQKQEKKRS KSKPTKKGGA KA
//