ID   G0N9Q1_CAEBE            Unreviewed;       844 AA.
AC   G0N9Q1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN   ORFNames=CAEBREN_00729 {ECO:0000313|EMBL:EGT55776.1};
OS   Caenorhabditis brenneri (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN   [1] {ECO:0000313|Proteomes:UP000008068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG   Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|ARBA:ARBA00006271}.
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DR   EMBL; GL379852; EGT55776.1; -; Genomic_DNA.
DR   AlphaFoldDB; G0N9Q1; -.
DR   STRING; 135651.G0N9Q1; -.
DR   EnsemblMetazoa; CBN00729.1; CBN00729.1; WBGene00139454.
DR   eggNOG; KOG0220; Eukaryota.
DR   HOGENOM; CLU_002472_7_3_1; -.
DR   InParanoid; G0N9Q1; -.
DR   OMA; KMTMLYK; -.
DR   Proteomes; UP000008068; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblMetazoa.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0051026; P:chiasma assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0000712; P:resolution of meiotic recombination intermediates; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008068}.
FT   DOMAIN          662..678
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|PROSITE:PS00486"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          759..786
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   844 AA;  96836 MW;  125E0D4464516010 CRC64;
     MYSNKTLHRR QRQQITESRS EERFSNSLIR LNGQSLHDTT GNNTTTKNIN SDVVIVIMEG
     RGMSEGQIGI AMHDVRYPEI HLCEFVDSKE YTTLKTMINV HEAYDIVIQN GNEERGSTKL
     LGEALMTAFP DASLQSISSK YFKSERGERQ LHSLMNAEVS TVSEGCFRRY LALGALAVLL
     KYIHETRCVF FRVKSLRIKE MGVDDTCMID FVSWESLEII DTDDASKARK CQMKQKRTLM
     SVLNHTVTTN GYRLLRSNVL QPSTDVSIIE ARQEAIEELI AKPQLREKLR KTLLRAHELD
     RVIAMCIQTS SSWTVRESEA KINQIIKLVQ TLKVIQGIRE LLESARVKSQ LLNEKIEFLK
     DPSFDQIMDI LLEKVDDTLL DGRKNSLHLQ NTKCYAIRNF VAVQLDLARQ TYEELIGNVE
     ETGAREIAEH FHNNSSVRLS FSQARGFHYT FVTRQAESVT IPRHFLEVFR NRTTVTFNSR
     QVIACNDRLE QVVAEMFLAS DVIVCDMIDD MQPMISVLYY AMDALSSIDF LCALATYSEL
     RDTCRPSFGE SFSISQGRHP ILDWADTEKT ITNDTCLTRD RRFGIITGPN MAGKSTYLKQ
     AALLAIIAQI GCFIPANYAT MPIFTRIFSR MGHNDELMRN KSAFASEMSD AASIVQYADK
     RSLVVMDELA RSTSTEEGIA ITYAICEKVL ELKSYTFLAT HFLDIAALAN FSNAIDNYHF
     LPQIDERSLK KHKLLRGQYR GPLYGFELVE LSTFPEEVME HAQTLANELR AQVEDLERDY
     ESERRRVKVF MSHRLRESAE YFMETYGENW KTEKAAIEKM TSLRNYMIEE LKKIDSQEEM
     DQNE
//