ID G0NCK8_CAEBE Unreviewed; 598 AA.
AC G0NCK8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Beta-glucuronidase {ECO:0000256|ARBA:ARBA00016205};
DE EC=3.2.1.31 {ECO:0000256|ARBA:ARBA00012761};
GN ORFNames=CAEBREN_12535 {ECO:0000313|EMBL:EGT57606.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the degradation of dermatan and
CC keratan sulfates. {ECO:0000256|ARBA:ARBA00003025}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
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DR EMBL; GL379863; EGT57606.1; -; Genomic_DNA.
DR AlphaFoldDB; G0NCK8; -.
DR STRING; 135651.G0NCK8; -.
DR EnsemblMetazoa; CBN12535.1; CBN12535.1; WBGene00151260.
DR eggNOG; KOG2024; Eukaryota.
DR HOGENOM; CLU_006501_6_1_1; -.
DR InParanoid; G0NCK8; -.
DR OMA; IHDHVGW; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0004566; F:beta-glucuronidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR10066; BETA-GLUCURONIDASE; 1.
DR PANTHER; PTHR10066:SF67; BETA-GLUCURONIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068}.
FT DOMAIN 4..193
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 201..288
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 290..588
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
SQ SEQUENCE 598 AA; 68402 MW; 7CAF2496CD78FD7F CRC64;
MRTFDSLDGL WTFVKEPHNS DDIGIKNQWN TLDLEKFHNA TVMPVPCAYN DIGTSAELRD
HIGWVWYEKK EFVPLRDSNM NHVLRFGSVN YFAVVYVNSE KVTSHTGGHL PFEVDVSSKI
KYGAENKITV AVNNTLSWST IPQGDFNYQK LNPRNISGRI LSRLPDGAVK NVGNFDFFNY
AGILRSVQLV KIPSIHIQNI NIVAEHTGSF VFETAATNLD GVKVEVKMFD ADQNLVYSTN
QTKGEGKLDN AKLWWPRGMG DANLYTLEVS LISDGNLVDI YRETFGFRTV SLSDSQMFIN
TKPFYCLGFG MHEDFELIGR GFNQAVMTKD LNLLEWMGGN CYRTTHYPYS EERMFENDRR
GIAVIVETPA VGLKGFSKAN NNLHVKMLTD MIDRDKNHPS VIAWSLANEP VTSKKESRAY
FKTLVDTAHG IDRTRPVTTV YGPTNFDNDE TADLMDFICV NRYYGWYIDM GYIPWINQSV
YWDISLWRET FHKPIMVTEY GADSIPGLNQ EPAVDFSEQY QNEVIQETHH AFDALIKDHT
ITGEMIWNFA DFMTGMTTTR AVGNHKGVFT RSRQAKIAAY TLRNRYNKKL DQTNLEIW
//
