ID G0NFD4_CAEBE Unreviewed; 649 AA.
AC G0NFD4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Interference hedgehog {ECO:0000256|ARBA:ARBA00041099};
GN ORFNames=CAEBREN_00942 {ECO:0000313|EMBL:EGT59198.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates response to the active Hedgehog (Hh) protein signal
CC in embryos, functioning upstream or at the level of patched (ptc).
CC {ECO:0000256|ARBA:ARBA00037573}.
CC -!- SUBUNIT: Homodimer. Heterotetramer; 2 iHog chains bind 2 hh chains when
CC facilitated by heparin, heparin is required to promote high-affinity
CC interactions between hh and iHog. {ECO:0000256|ARBA:ARBA00038530}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. IHOG family.
CC {ECO:0000256|ARBA:ARBA00038144}.
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DR EMBL; GL379875; EGT59198.1; -; Genomic_DNA.
DR AlphaFoldDB; G0NFD4; -.
DR STRING; 135651.G0NFD4; -.
DR EnsemblMetazoa; CBN00942.1; CBN00942.1; WBGene00139667.
DR eggNOG; ENOG502RYGH; Eukaryota.
DR HOGENOM; CLU_422262_0_0_1; -.
DR InParanoid; G0NFD4; -.
DR OMA; CISRPAM; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF53; BROTHER OF IHOG, ISOFORM G-RELATED; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..93
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 117..191
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 359..414
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 437..542
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 547..642
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 649 AA; 72295 MW; 325133826A924532 CRC64;
MRFLQAAITV RENEVARLPC AGMPDVIPSP AHICFQRMGS TEDCLGSKND TKYFVTESGM
QISLVTPLDA GFYICIVRNE FTNQSRRSQK PVLIVVTESN ITEKATPELI KPALVYPAKE
TTIDAPIELA VAEGEDIVLE CVINMAKIVW IKHNDTTPNV TMDDNTSRFQ QIWGNLKIRS
VALGDSGIYS CLGLPIVGWD GKIDNNTTRP RVDYNLVVYS PSGVRLSITQ QFNKRYLLEC
LATNLRYEIP TAYINGTSIV HNINSLGIPS NTNFYNNPIR VHMEVKSSFT GSIQCVSRPT
MVEAEIYGFG LERGKSMNMF VMNTHNSNDL IINGPKNITV LVGQTADFPC IVQRVKARSW
MKNNRTLSLF TSRRTILGSN SLRISKVELG DEGMYTCVAQ SESGHTSYSS AYLTVTDNTP
TKAPVVTSTE PFLDKKKDMK IDVEDVRGFV TGTEVRIQWS VLGKMEALTK IAKFLIEAQR
FGTPEDSWIE AESVASHVRA TTIKSLIPDN KYKFRIKMIR DDGTHVLSLP TDWMNVEATS
GDVLPMAPKI YSVYQWSTDS AKVLFTHNVL IENAAAKTFV IVYNEVSSDQ NKSQVVQVDG
NQNEAIITGL TLETQYLIRA IAENSAGKSL NSNEYIFNTT PLIIFEQTN
//
