ID G0NLP8_CAEBE Unreviewed; 817 AA.
AC G0NLP8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN ORFNames=CAEBREN_08948 {ECO:0000313|EMBL:EGT33839.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436,
CC ECO:0000256|RuleBase:RU003431};
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; GL379906; EGT33839.1; -; Genomic_DNA.
DR AlphaFoldDB; G0NLP8; -.
DR STRING; 135651.G0NLP8; -.
DR eggNOG; KOG1023; Eukaryota.
DR HOGENOM; CLU_001072_1_3_1; -.
DR InParanoid; G0NLP8; -.
DR OMA; TVANERW; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF265; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-1-RELATED; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..817
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003405076"
FT TRANSMEM 242..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 291..589
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 627..689
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 817 AA; 92952 MW; 0B6B951EBB7E600E CRC64;
MDVIWKVLSL FILFYEVDGQ LISTYNGTAN STAGSRRTIK VGIAAAQQIQ TGSIGWSVCG
GAVPLAIEKL KQAGYAKNFD FELGFAAAKM LQQYRWGRIA MLYYQSDLDY CSKVMDDVEA
TFNDQDTPVN IVIKAEMYLN DDETTDIVLQ SVKSRARSMT GEVVISTNLT RMSIFQLYGL
NAQYDQAAYI NFTFINDKMS VSVFYKDEAT TVWHFYGYSR PLDTPICGFL GKSCPVSFWE
QYRILIVVAI ILILLLMVLI LVGCCCMISS RRAEQERINS EWQIPFLKLL EPEKRQRAHG
ASKRSLQSAP STATGDSRLT AISDFCENYT IMVYEKDMVL TAKHQYTHLT KADMERFVKL
RTLEHENLNK FIGLSIDSSH FIAVSKLCSR GSLQDILSRG NFSMDYFFMF CIIRDVAKGM
DYLHKSFLRL HGNLRSATCL VNDSWQVKLA EYGLDNLDEE QTPPKKRLLW VAPEVLRGSL
SVSQMDSSAD VYSFAIIASE ILTRKEAWDF LDRKEDCEEI VYMVKKGGPF PIRPEIVTDI
PDVNPTLISL VKDCWAENPE DRPTANSICT QLKSMMPKSK SNLMDHVFNM LEEYTATLEV
EIEDRTKELT LEKKKADLLL SRMLPQQIVD MSLRFMEYCS HFKIPHLPRE KVELRIGINS
GPCVAGVVGL SMPRYCLFGD TVNTASRMES NGKPSMIHMT ADAYSLLITH YPHQYETSSR
GEVIIKGKGV METYWVLGKV EDYMDNFGRR ETLPVHELVE FKPEPILKQS ANKKEEVSEE
CSLKGKEIRS VSSHSSRSSS VFNPLKDHRE FKMEMCV
//
