ID G0NNG1_CAEBE Unreviewed; 478 AA.
AC G0NNG1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EGT34543.1};
GN ORFNames=CAEBREN_26318 {ECO:0000313|EMBL:EGT34543.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; GL379914; EGT34543.1; -; Genomic_DNA.
DR AlphaFoldDB; G0NNG1; -.
DR STRING; 135651.G0NNG1; -.
DR MEROPS; C01.166; -.
DR EnsemblMetazoa; CBN26318.1; CBN26318.1; WBGene00184989.
DR eggNOG; KOG1542; Eukaryota.
DR HOGENOM; CLU_012184_10_1_1; -.
DR InParanoid; G0NNG1; -.
DR OMA; KNDCDAG; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.10.450.10; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF959; CATHEPSIN F; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00031; Cystatin; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..478
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018605779"
FT DOMAIN 176..233
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 265..476
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 478 AA; 55079 MW; F71371589C97E147 CRC64;
MGKPAICLLL FSTILISLVT SKVLPIDEED QLLYERFARQ GVEKFNQQSN DVYKWELDRT
WEVERKLSGG IHYSIFVTLV KTDCKKGQET GETGEKCRKT DTLKKCQVEI SRRVKRHGYG
LKDIAHIKNC EEEFTRNIAK FDHRKIKLTH DDSVTVQELR KAKIIKPRDY VVWNSFLDFI
DRHEKRYENK REVLKRFRVF KRNAKVIREL QKNEQGTAVY GFTKFSDMTT MEFKETMLPY
QWEQPVPMDQ ANFEKEGVTI SEEDLPDSFD WREHGAVTQV KNQGSCGSCW AFSTTGNIEG
AWFLAKKKLV SLSEQELVDC DSVDQGCNGG LPSNAYKEII RMGGLEPEDA YPYDGRGETC
HLVRKDIAVY INGSVELPHD EVEMQKWLVT KGPISIGLNA NTLQFYRHGV VHPFKIFCEP
FMLNHGVLIV GYGKDGRKPY WIVKNSWGPT WGEAGYFKLY RGKNVCGVQE MATSSLVN
//
