ID   G0NUA6_CAEBE            Unreviewed;      1054 AA.
AC   G0NUA6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Upf1 domain-containing protein {ECO:0000259|PROSITE:PS51997};
GN   ORFNames=CAEBREN_04117 {ECO:0000313|EMBL:EGT37736.1};
OS   Caenorhabditis brenneri (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN   [1] {ECO:0000313|Proteomes:UP000008068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG   Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC       {ECO:0000256|ARBA:ARBA00007913}.
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DR   EMBL; GL379948; EGT37736.1; -; Genomic_DNA.
DR   AlphaFoldDB; G0NUA6; -.
DR   STRING; 135651.G0NUA6; -.
DR   EnsemblMetazoa; CBN04117.1; CBN04117.1; WBGene00142842.
DR   eggNOG; KOG1802; Eukaryota.
DR   HOGENOM; CLU_001666_4_1_1; -.
DR   InParanoid; G0NUA6; -.
DR   OMA; VRSNDNQ; -.
DR   Proteomes; UP000008068; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   CDD; cd21407; 1B_UPF1-like; 1.
DR   CDD; cd18039; DEXXQc_UPF1; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   CDD; cd21400; ZBD_UPF1-like; 1.
DR   Gene3D; 2.40.30.230; -; 1.
DR   Gene3D; 6.10.140.1240; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR040812; UPF1_1B_dom.
DR   InterPro; IPR018999; UPF1_CH/ZBD.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR   Pfam; PF13086; AAA_11; 2.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF18141; UPF1_1B_dom; 1.
DR   Pfam; PF09416; UPF1_Zn_bind; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51997; UPF1_CH_RICH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT   DOMAIN          81..238
FT                   /note="Upf1"
FT                   /evidence="ECO:0000259|PROSITE:PS51997"
FT   REGION          89..121
FT                   /note="C3H"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          103..131
FT                   /note="CC/SHH/C"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          149..179
FT                   /note="C4"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          978..1034
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        979..1034
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1054 AA;  118455 MW;  8065AEE53357625E CRC64;
     MDDFDDHYSK SGGETLTFVD TDECGMSAAT QDSQFYDNQF SVPTQSSQVT DFLPGVDATS
     ELTFHDVEDE SEDEKSLTDD QQKLPEHACK YCGISDPLCV AKCTVCNKWF CNSNDGTPGG
     HIVHHMVRSQ HKEAYTHKDS PCGDTQLECY RCGSKNVFNL GFIPGKKDQV VVIICRTPCA
     NLAFQNDDNW SPEDWKSVIA EKQLLSWIVN TPSEEQVARA RKITAAQAVR LEELWREHPD
     ATLDDLNKPG LDREPDHVQL KYTDAHHYSK IFRPLVAIEA EYDRRMKEQA SQAVGTVRWE
     QGLRGSVCAF FHLPQFADGV MKLAKGDELR LKHNQTVDGS EWAKVGNVFK IPDNHSEEIG
     IEIRGQVDRS VQESRIMFTV DVVWNATTFD RQYRALQALQ TDNQSVSPYL YAKLLGKPVD
     ELMLKFELPR RLSAPGLPDL NSSQMQAVKQ VLTRPLSLIQ GPPGTGKTVV SATIVYHLVK
     KTEGNVLVCS PSNIAVDHLA EKIHKTGLKV VRLTAKSREH TDTTIPYLTL QHQLKVMAGP
     ELRKLIQLKE EIGELEAKDD IRYSQLKRVK EHDLLAAADV ICCTCSSAAD ARLTKIRTRT
     VLIDESTQAT EPEILVSIVR GVRQLVLVGD HCQLGPVVIC KKAAMAGLSQ SLFERLVLLG
     IRPFRLQVQY RMHPVLSEFP SNAFYDGSLQ NGVTENDRYM KGVDWHWPTH NKPAFFWHCS
     GAEELSASGT SFLNRTEAAN VEKLVSKLIK GGVQPLQIGV ITPYEGQRSF IVNYMHTQGT
     LNSKLYESVE IASVDAFQGR EKDYIIVTCV RSNDALGIGF LSDPRRLNVA ITRAKYGMVV
     VGNAKVLSRH ELWYELINHF KKKDMLYEGP ISALKPLNMT IPKPVLKAKN NIAGNTNRFG
     IKRMQYTYNE YKASDPSVPR LPPTYANSQN LLSMSKLARN FNQNTPVPAH MLDPLVYGHR
     SQKDRRREQH RQRAEAAMDF SQDISQSQYG GPSQSQYNDG ASLSGWSQSQ TAVVNGNSKN
     RNRPQYQGNT QQMSQDMDEV EQKMVDLLLM SQDC
//