ID   G0P884_CAEBE            Unreviewed;      1632 AA.
AC   G0P884;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012494};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
GN   Name=Cbn-ego-1 {ECO:0000313|EMBL:EGT47646.1};
GN   ORFNames=CAEBREN_12632 {ECO:0000313|EMBL:EGT47646.1};
OS   Caenorhabditis brenneri (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN   [1] {ECO:0000313|Proteomes:UP000008068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG   Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517};
CC   -!- SIMILARITY: Belongs to the RdRP family.
CC       {ECO:0000256|ARBA:ARBA00005762}.
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DR   EMBL; GL380128; EGT47646.1; -; Genomic_DNA.
DR   STRING; 135651.G0P884; -.
DR   EnsemblMetazoa; CBN12632.1; CBN12632.1; WBGene00151357.
DR   eggNOG; KOG0988; Eukaryota.
DR   HOGENOM; CLU_001939_0_0_1; -.
DR   InParanoid; G0P884; -.
DR   OMA; RSMMENY; -.
DR   Proteomes; UP000008068; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF54; RNA-DIRECTED RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022484};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   REGION          1063..1085
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1069..1085
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1632 AA;  190102 MW;  5F55B64F76FF3823 CRC64;
     MGDDGYRGWI KLEVPCSFPE RQMNNIIRCH TSKLEPALNH MNMRIQTKGQ VQVAEEQDCE
     PFYEANYEVV SDRFSHHLIV AIQNYLKDLA ADHLMPFQRG NLVLHSSDFW STELTCHLVD
     IPLAAFFFGN IQGGTFINHW EVSFWEDTLR RNRDRVKNIA PTVSDKIGMN QIKVEFEFDK
     VDFMTVHFKH KEADFEVMDK DQRKTRQTVT MYYQITVRRT SIRRVIVDPV VHDVNGTDRV
     RVHFELNCPV LIRRAFRTEK QEAEFRHVVP HYKRNLIINR GRTANQYPTA KAITDSPVFT
     IEFDSSVCMV EIYRLLSRLR VRTGVSIEFA DIPSVDCLIW RENPYHRWTF SNGQHLSPTH
     FSAPIYRDFI TTAFPRRHEV CGSREIDTNR ERKFAITYLL ECLISRGAVV KDQILLDEII
     WHRFLEVILH YYTKDDKLCE AGLEDLVHMI DGRKRIGSLI KCFDRICQTR QKNSLVNGLT
     TEEMREGYQR VRKIIFTPTR VIYVAPETLM GNRVLRRYDH DGTRVLRITF RDDDNQKMRT
     NKTSTLLEKT VNNYLHSGIT VAGRNFGYLG SSNSQMRDNG AYFMEKYSSS QCREYEAIHH
     VKPPITYNPK IQAARKNLGR FETIDNIPKM MARLGQCFTQ SRLSGVNLDR CTYMTMYDLT
     GGKNIKRDEY TFSDGVGMMS LRFAQMVSQV MDFGKGVPSC FQFRFRGMKG VIAVEPLLDM
     IRKWSLEFAL EKPSDDVAWG LNCVFRPSQI KFISKRHPRD QVEIVKYSSP VPVSLNKPFI
     NILDQVSEMQ SLECHRRVTN RIEELLDRQM LLFAQQMVDE TFCRNRLKEL PRRVDIDYLR
     TTWGFTLSSE PFFRSLIKAS IKFSITKQLR KEQIPIPQDL GRSMLGVVDE TGRLQYGQIF
     VQYTKNLALK LPPKNAARQV LTGTVLLTKN PCIVAGDVRI FEAVDIPELH HMCDVVVFPQ
     HGPRPHPDEM AGSDLDGDEY SIIWDQQLLL DKNEDPFDFT SEKQKSSFKE EEIDDLMREF
     YVKYLKLDSV GTISNSHLHN SDQYGLNARV CMDLAKKNCQ AVDFTKSGQP PDELERKWRK
     DEETGEMIPP ERCERVPDYH MGNDHTPMYV SPRLCGKLFR EFKAIDDVLK ISEERDEQVE
     ISIDENIMMD GYESYMHSAR DELSRYNAQL RSMMENYGIK TEGEVFSGCI VDMRNRISDK
     DQDDMSFYNT NQMIETKVTN LFKKYREHFF EEFEGGWEAN TESSSRIGSD ANILQRQCRA
     PTQKMMRKAV AWYRACYEEA RITRENKKLS FAWIAFDVIA MVKQTRSLAS DDVQMGGANP
     LFTMLDDHRS QYLIDNEEAF ETFSRFKTSK SAGEQVRRAN GIIQMYVEMN PGLDEVLYIL
     NEWATKSKLF DSQPLRNYHF SLLFLLFATR QISSVDGNAG AFFNKIDENN FKLSKESGAM
     VPNHELTNKQ KSHMTVKFLE FLASRKFRKM ANLSFRTLDF TSIFLRGEWQ IFHVAALKTY
     YNVLFNLRFE ELPVSTDPTM TIRSTIRENE PFVIELPAKC DQQLVHRKLM EHTGVEEIFM
     RCMEKSVRAE NEPQKANVRL LVSTRGTLEA MYKLRQLVAV KVPIKTYVTG QEISSQMARL
     CYEKIIKGHI NN
//