ID   G0P8R6_CAEBE            Unreviewed;       376 AA.
AC   G0P8R6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Fatty acid desaturase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CAEBREN_24487 {ECO:0000313|EMBL:EGT48003.1};
OS   Caenorhabditis brenneri (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN   [1] {ECO:0000313|Proteomes:UP000008068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG   Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
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DR   EMBL; GL380138; EGT48003.1; -; Genomic_DNA.
DR   AlphaFoldDB; G0P8R6; -.
DR   STRING; 135651.G0P8R6; -.
DR   EnsemblMetazoa; CBN24487.1; CBN24487.1; WBGene00163212.
DR   eggNOG; ENOG502QQNB; Eukaryota.
DR   HOGENOM; CLU_033094_1_0_1; -.
DR   InParanoid; G0P8R6; -.
DR   OMA; IGQHIFH; -.
DR   Proteomes; UP000008068; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProt.
DR   CDD; cd03507; Delta12-FADS-like; 1.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   InterPro; IPR021863; FAS_N.
DR   InterPro; IPR012171; Fatty_acid_desaturase.
DR   PANTHER; PTHR32100:SF82; DELTA(12) FATTY ACID DESATURASE FAT-2; 1.
DR   PANTHER; PTHR32100; OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC; 1.
DR   Pfam; PF11960; DUF3474; 1.
DR   Pfam; PF00487; FA_desaturase; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        68..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        205..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        233..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..58
FT                   /note="Fatty acid desaturase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11960"
FT   DOMAIN          70..323
FT                   /note="Fatty acid desaturase"
FT                   /evidence="ECO:0000259|Pfam:PF00487"
SQ   SEQUENCE   376 AA;  43543 MW;  032BF3C25E3ED8FA CRC64;
     MTIATKVKTS KKDLDSIKVP ELPSVAALKA AIPEHCFVKD PLVSISYLIK DYLLLAGLYF
     AVPYIEQYLG WVGLLAWYWA MGIVGSALFC VGHDCGHGSF SDYEWLNDLC GHLAHAPILA
     PFWPWQKSHR QHHQYTSHLE KDKGHPWVTE EDYNNRTAIE KYFAVIPISG WLRWNPIYTI
     VGLPDGSHFW PWSRLFETTE DRVKCVVSGV ACAICAYIAF VLCDYSVYTF VKYYYIPLLF
     QGLILVIITY LQHQNENIEV YEPDEWGFVR GQTQTIDRHW GFGLDNIMHN ITNGHVAHHF
     FFTKIPHYHL LEATPAIQKA LEPLKNTQYG YKREVNYDWF FKYLHYNVTL DYLTHKAKGV
     LQYRTGVEAA KAKKAH
//