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Database: UniProt
Entry: G0PE01_CAEBE
LinkDB: G0PE01_CAEBE
Original site: G0PE01_CAEBE 
ID   G0PE01_CAEBE            Unreviewed;       395 AA.
AC   G0PE01;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=Acid ceramidase {ECO:0000256|ARBA:ARBA00040588};
DE            EC=3.5.1.23 {ECO:0000256|ARBA:ARBA00011891};
GN   ORFNames=CAEBREN_00023 {ECO:0000313|EMBL:EGT52618.1};
OS   Caenorhabditis brenneri (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN   [1] {ECO:0000313|Proteomes:UP000008068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG   Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine;
CC         Xref=Rhea:RHEA:20856, ChEBI:CHEBI:15377, ChEBI:CHEBI:28868,
CC         ChEBI:CHEBI:52639, ChEBI:CHEBI:57756; EC=3.5.1.23;
CC         Evidence={ECO:0000256|ARBA:ARBA00036977};
CC   -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC       {ECO:0000256|ARBA:ARBA00004760}.
CC   -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC       Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the acid ceramidase family.
CC       {ECO:0000256|ARBA:ARBA00005730, ECO:0000256|PIRNR:PIRNR017632}.
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DR   EMBL; GL380299; EGT52618.1; -; Genomic_DNA.
DR   AlphaFoldDB; G0PE01; -.
DR   STRING; 135651.G0PE01; -.
DR   MEROPS; C89.001; -.
DR   EnsemblMetazoa; CBN00023.1; CBN00023.1; WBGene00138748.
DR   eggNOG; ENOG502QVBG; Eukaryota.
DR   HOGENOM; CLU_054401_0_0_1; -.
DR   InParanoid; G0PE01; -.
DR   OMA; HEWEISS; -.
DR   Proteomes; UP000008068; Unassembled WGS sequence.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-UniRule.
DR   GO; GO:0017064; F:fatty acid amide hydrolase activity; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   CDD; cd01903; Ntn_AC_NAAA; 1.
DR   InterPro; IPR016699; Acid_ceramidase-like.
DR   InterPro; IPR029130; Acid_ceramidase_N.
DR   InterPro; IPR029132; CBAH/NAAA_C.
DR   PANTHER; PTHR28583; ACID AMIDASE; 1.
DR   PANTHER; PTHR28583:SF1; ACID CERAMIDASE; 1.
DR   Pfam; PF02275; CBAH; 1.
DR   Pfam; PF15508; NAAA-beta; 1.
DR   PIRSF; PIRSF017632; Acid_ceramidase-like; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR017632};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|PIRNR:PIRNR017632};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..395
FT                   /note="Acid ceramidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003406819"
FT   DOMAIN          47..105
FT                   /note="Acid ceramidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15508"
FT   DOMAIN          142..323
FT                   /note="Choloylglycine hydrolase/NAAA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02275"
FT   ACT_SITE        142
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR017632-1"
SQ   SEQUENCE   395 AA;  44844 MW;  36C9122B37B55447 CRC64;
     MLRNVSILLV LAVSWALAKH VELPAPYKDH CILDDKTNLY DPSKSFDIPW FDVNLDLPPS
     ERWKQVGAAY KTQINDLIGV LIDLITPVFP NALEFCDDVF GDMAPKLAQP YRDEIYSISE
     VTGIPLGRIT MYNIFYEIFT VCTSIIAQDM DGHLTHARNL DFGLFMGWDA NIHDWPISQK
     LRKMIINVNW VKDGKLLFKS NNFAGYVGIY NGLKPNAFSL TADDRFQLEG GYYGILKWLF
     GLEADGKWMS WLARETLEQK TTYLEAKEHL MNTPMLSPVY FILGGAKKDE GCIIARSLNG
     TAILSEMADS PHGWYLLETN YDQGTEALYL DDRDTPGIRC MDKLTQKNAG FQGIFNVLSS
     RTNLNKLTTY TVLMSVETAR FETILQSCPG ECYPW
//
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