ID G0PGU0_CAEBE Unreviewed; 1421 AA.
AC G0PGU0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
GN ORFNames=CAEBREN_31128 {ECO:0000313|EMBL:EGT55630.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; GL380445; EGT55630.1; -; Genomic_DNA.
DR STRING; 135651.G0PGU0; -.
DR eggNOG; KOG3610; Eukaryota.
DR InParanoid; G0PGU0; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF44; PLEXIN-B; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01833; TIG; 2.
DR SMART; SM00429; IPT; 2.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1421
FT /note="Sema domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003406333"
FT TRANSMEM 1159..1181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..445
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1185..1212
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1421 AA; 157811 MW; B0DDAF03D7346002 CRC64;
MLFNDLLFIL TMGCGAISSL KPSSSKADQE NILYSTESID SFIASRDQGT IYFASTNHLI
SVSPTNFSIL NKISLGPVRD SPWCDTNGQS CLKDNRPSLT DVHTKILHYL PSNQILQCGS
VKLGSCSIYN PKLILVTKSN VSVAAIAPEA STVSQIMDNR LVVAATATEE SPYRDPFPSV
SIRELPGLNV ENAGDLNGEA AVFLRPYYRG KFRFVEIFSY ENFVFVVATV TLRDARSPVT
TRLIRFCKND TKFASYSEIE LQCRGEDNTN YPFLNALVRD GDKMVASFTV STNSAHSSIC
IFSMQKVKLT FWYNLDKCRS GADSIKLPHI GRDAKCVNKA HIPLDENSCE LGVGGSIELV
EISVKNISSK VTSLMSIDQK VVFAGTSSSQ ILLLKWNDSS NPISLDEYGR KEVGNMKTGN
EVQKMVRYGD NVLIQMKYGI IMKEISKCAD HKSCTECLFS VDPLCRWCHP TQSCTTSSTC
VGQSTLQCPS VEAYPIPSKV SVNTTTEVFF KISHLPPPVG FIYECQFGPE RVVANWNLSG
LSCSSGFFGF SDVLEVSLMT SLSKKHISRH NITVFDCSDY ATCSQCIGSN FGCQWCSRSH
ECSKACSYSA VNTCIKIQPM KLPLAIGSLQ EIVMEATNLD TLDKNVNHFC KIEDQTVPAT
IAQHSFRCGK IRLMSKSEPS EIMNIPLSLM AGNITLEVTN VSLYSCSTLA SDCSSCRALQ
PSLSCSWCNQ RCSHECEELE ESIGCDPPRI DKPKFRVIEI TDADTCFVFQ FEPSSGPVEG
GTIIRIYGND LGTSLEDVQG KIYVAGSKCN LVKYQVSNMI ECQVDRGVSS GPIRISVGRA
TVTVVESQDL FSFVPVSIFS AYPLYGPISG GTSVILYGQN LLSGSKINVT IGEMPCSISQ
RNSSSTLSCV SPAGSRVGKS TKVSVRIDHS HIQLNQPFEY RPDPEIRSIF PSATFKAGGK
ILSVQGYSLN SVQTAKIYLM SSPYYPFDIS QNWAPCHIIN STLNDMPGPQ KILKAKTRNV
EYGKYSVGFL DGTMVSDVRK PRRFLLGNER CYVTLVDIKP ARLLGAYKAT ESTDEKRRKL
GLIEYSEHGH PSXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XRMELGLIEY SEHGHPSRIL LLIFSLGFLV AITVIIAGNL LRRKKRERAQ EYHKIKIQMD
NLEKNVRKEC KQAFAELQTN LALSPKPIGK TTQPEIVDFS RFMENLLWAE NTLTVPILAR
TLPMALAQFH ALLSFKEFIF TIVDVAESRN SISTSEKSML ASLLISVLIR NFSYCTEIVI
SLLKTHITKA VENKRAELLF RNSDSLVEMM ISKWWCICLY PSLKPQMNSF YNLYKALQFQ
TDRGPVDAVT GDARYTINEA NLLRECVETR TILLHQKNNK Y
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