ID   G0PH05_CAEBE            Unreviewed;       906 AA.
AC   G0PH05;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   ORFNames=CAEBREN_14794 {ECO:0000313|EMBL:EGT55883.1};
OS   Caenorhabditis brenneri (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN   [1] {ECO:0000313|Proteomes:UP000008068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG   Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC   -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC       {ECO:0000256|ARBA:ARBA00005884}.
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DR   EMBL; GL380454; EGT55883.1; -; Genomic_DNA.
DR   AlphaFoldDB; G0PH05; -.
DR   STRING; 135651.G0PH05; -.
DR   EnsemblMetazoa; CBN14794.1; CBN14794.1; WBGene00153519.
DR   eggNOG; KOG1815; Eukaryota.
DR   HOGENOM; CLU_320352_0_0_1; -.
DR   InParanoid; G0PH05; -.
DR   Proteomes; UP000008068; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20343; BRcat_RBR_HHARI-like; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR045840; Ariadne.
DR   InterPro; IPR048962; ARIH1-like_UBL.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR11685:SF212; E3 UBIQUITIN-PROTEIN LIGASE ARIH1; 1.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF21235; ARI1_UBAl; 1.
DR   Pfam; PF19422; Ariadne; 1.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF01485; IBR; 2.
DR   SMART; SM00256; FBOX; 2.
DR   SMART; SM00647; IBR; 2.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS51873; TRIAD; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          539..740
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   DOMAIN          543..590
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
SQ   SEQUENCE   906 AA;  105621 MW;  FAB29853D3742CA5 CRC64;
     MPDLLEIDEG TSKIVDTMRE WNRVFPEITS DQAISVENDL MLKVRNLIIT TYEVIFDFVK
     TKSSSLKEQK HAGDLILTEI SSRISGHEEL LEKMLKTQVN QHEFNKNILD SVKSLRVHQN
     EQNTKICHIM TRISERDLVI KHCGERLDEL EKQNRKGGKR VRFSDVIDYK FHTNWSDLSE
     DLKLKCIKQM DFQDRLRLRS TAHTERRLVD SQRFVFDEIN LFHSDSFIAT WNNLKCTKYQ
     LLPRTGFLKT PEEISRIQSL TELLVYILNH CNIRNLSVEQ LPGEHVSILE ELDDLVDDNS
     VKIKNFRSDF FSQTTKFFLK KSWKKLDSVS IEQHGFYGKE LIAIPSVAAA KNYFLTNGQG
     SRRLLPLVTN FMFRNGEIGT KLVVNCMDKA LFNKVISTYC WRAILHLRQT SKTEKYLVDV
     EGIGMEKKKR GEQKVENLVE KDDDAAGEYC PIYGDSDDDD DKDEPDFKVR SHESLYAEMK
     KKIGEAQELL EMRPGICQIL LQKYKWSVAF LMEKFYDNPD RGAFLTAVNV DPSEHLHAIV
     GECQICFEEQ ELTGLSCEHR YCWDCLREYM IDKIFDGQSE IKCIGLECPL VFEEEKIGSI
     VIDPEVMSCY HRLLVQKYVQ NDAFMKSCPD LSCENTIQVL NPSIRHVKCN CGYSFCFSCG
     NDSHEPISCR YLDKWLLKGD EDQSSVWILT NTKKCPKCNA PIEKNGGCMH MTCHSKDCRY
     EFCWLCMRDW RAHANCNDFQ RTNDAAREAM INKTIADRDR YKFYHDRYAG HMQSLKLEKP
     LRAKFDEQMK EIEDGDRDLR DFQYIYVAID ALSASRRTLM HSYVFAFFLE ENYSAIIFKS
     NQADLNDATE NLSKVLEEFV NSESVGFADD SKKEIMHKSQ YVEQRRKALI EHCIEGDDND
     DWVFNE
//