ID G0RBL2_HYPJQ Unreviewed; 896 AA.
AC G0RBL2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=DNA repair rad4-like protein {ECO:0000313|EMBL:EGR51075.1};
GN ORFNames=TRIREDRAFT_75205 {ECO:0000313|EMBL:EGR51075.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR51075.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR51075.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; GL985058; EGR51075.1; -; Genomic_DNA.
DR RefSeq; XP_006962629.1; XM_006962567.1.
DR AlphaFoldDB; G0RBL2; -.
DR STRING; 431241.G0RBL2; -.
DR EnsemblFungi; EGR51075; EGR51075; TRIREDRAFT_75205.
DR GeneID; 18488446; -.
DR KEGG; tre:TRIREDRAFT_75205; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_75205; -.
DR eggNOG; KOG2179; Eukaryota.
DR HOGENOM; CLU_003639_0_2_1; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984}.
FT DOMAIN 528..587
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 589..652
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 659..733
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..357
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 101589 MW; 7DD1B199A1F25B75 CRC64;
MPPYVPRKRL RASSPGEAVE PDKSANSLLH DLGGSGDSDS PLSSLSDSDF EDVPLAKRQK
TDDADVEEEE DDEDDDDIEF EDVEAPQQFA PDAPVPSGDL ELTLIRDTRI SLTNQFDRKG
PSKRERTVRN ATHCVHVLCL LWHNAVRNSW ICDPEVQAIM ISHVPPRLWD EVDRWRQNSG
LVARPPPSKK MARKKGAKQD SRDWGDTAKR LEEGAIDMSH GDPLFRLMKS LVAWWKQRFR
VTAPGLRKWG YMSLERLDRL TKAYKEHEAD FEEFGERIEG IEGFRQCAAD CRGSRDVGAQ
LFTALLRGLG IDARMVASLQ PLGFGWNKLE DADPEEQLPA VTQESDDDLE PDFKDTDDES
VDMTLTTPTK SLHAKKFDKD LEFPHYWTEV LSPVTKKYLT VDPIVKGTIA TNRDLIETFE
PRGAKADRAR QVIAYVVGYS RDGTAKDVTI RYLKRQVLPG RTKGVRMPPV KVPVYNRHGK
VKRYELSDWF KTAMSGYRRG GKDHPLTEVD QQEDLTDLKP AKAEKKEVKE GEETLQYYKQ
SKEYALERHL KREEALRPGA KPVKVFKNKG KGGKVDEEDV YLRSDVVLVK SAETWHKQGR
APLAGEEPLK RVPYRAATLN RKREILETEA MTGQKVLQGL YSFDQTDWII PPPIKDGVIP
KNEYGNIDLF AEHMCPEGAV HVPFRGVGKV CKRLGIDYAE AVVDFEFGHR MAVPVIQGVV
IAEEHHDRVM AELEKDEAER VRKEDEKRRK AALGMWRKFL MGMRIVERIR QEYGEIDESV
SVFGHSRGGA PAGSAPKVHD EELAGGFLPE GYEDEEDDQA RETSSFFPAL EEDDEGGDGD
LVMEDGRDES VGDSHTEARA ESSTKSRKYS TRSRKTRTTR EKKQTVIDED DQEDDD
//
