ID G0REB6_HYPJQ Unreviewed; 1095 AA.
AC G0REB6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=TRIREDRAFT_3208 {ECO:0000313|EMBL:EGR50242.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR50242.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR50242.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
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DR EMBL; GL985060; EGR50242.1; -; Genomic_DNA.
DR RefSeq; XP_006963537.1; XM_006963475.1.
DR AlphaFoldDB; G0REB6; -.
DR STRING; 431241.G0REB6; -.
DR EnsemblFungi; EGR50242; EGR50242; TRIREDRAFT_3208.
DR GeneID; 18484513; -.
DR KEGG; tre:TRIREDRAFT_3208; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_3208; -.
DR eggNOG; KOG0218; Eukaryota.
DR HOGENOM; CLU_002472_0_0_1; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984}.
FT DOMAIN 945..961
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 120675 MW; 268A98ABA9197F48 CRC64;
MAPLSKASEK KQKSLTAFFT PKAVNGTASS SQPAVPSSPT LANESILPSR KRPLDKDGEK
ANGSAEKAPK RAKGDDETID GESSFFRKDS SATAAASNRS PTSARAQRYR YDESNSQEYN
GNDSDDAETQ RRNEELHRKF VKKLGHPDAL SWGLKAQDSG ITGDDEDADA DPEEEEPPVA
SKAKKKGAKT GKLTPMEIQF LDIKRKHMDT ILIVEVGYKF RFFGEDARIA AKELGIVCIP
GKMRYDEHPS EAHLDRFASA SIPVHRLPVH AKRLVAAGHK VGVVRQIETA ALKKAGDNRN
APFVRKLTNL YTKGTYVDEN GELDSQDASA PSGGYLLCIT ETASKGAGTD ENVNVGILAV
QPATGDIIYD NFEDCFMRSE IETRLLHISP CEFLIVGDIT KGTDKLIQHL SGSSTNVFGD
RARVERVPKS KTMAAEAYSH VTQFYADQVK EASDNETASA LLDKVLRLPE AITICLSAMI
THLQEYGLEH IFGLTKYFQS FSTRSHMLIN GTTLESLEVY RNSTDHSQKG SLFWAVDKTL
TRFGQRLLRK WVGRPLLDRE RLDERLAAVQ ELLDKQSTPP VDDLERLLTT TKADLERSLI
RIYYGKCTRP ELLSVLQTLQ KIASHYSSIK SASDVPFDSP VIVNAITSLP QILDSVVSYL
DRINAYAAKK DDKYGFFREE YHTEEIQDHQ LGIAHVEHEL DEHRAVAAQK IKAKSVEYVT
VAGIEYLIAV PNKDIKNVPA SWSKISGTKA LSRFHTPEVI RLITERDQHR EALAAACDKA
FKDFLASIAS EYQPLRDAIS ALATLDCLLS LSKVAAQPGY TKPTFLPATS EPSISISQGR
HPMAEHMLES SYIPFSTTLS HPSALAHLIT GPNMGGKSSF VRAVALIVLL SQIGSFVPAD
ALELTFCDAI HTRAGARDNL FAGESTFMVE VTETARILRS ATPRSLVILD ELGRGTSTHD
GAAIAQAVLH HVVTETRCLT LFITHYQNLA HIADGLPGVT NVHMKFNAEK GPDGEEEITF
LYEVGEGIAH RSYGLNVARL ARIPKKVLDV AAEKSRQLEN EMRRRRLQGA CRTLAHVLES
GPDQLDHLIT SIEQL
//