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Database: UniProt
Entry: G0RS43_HYPJQ
LinkDB: G0RS43_HYPJQ
Original site: G0RS43_HYPJQ 
ID   G0RS43_HYPJQ            Unreviewed;       599 AA.
AC   G0RS43;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   RecName: Full=tRNA(Ile)-lysidine synthetase {ECO:0000256|ARBA:ARBA00013267};
DE            EC=6.3.4.19 {ECO:0000256|ARBA:ARBA00013267};
DE   Flags: Fragment;
GN   ORFNames=TRIREDRAFT_66877 {ECO:0000313|EMBL:EGR46086.1};
OS   Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN   [1] {ECO:0000313|EMBL:EGR46086.1, ECO:0000313|Proteomes:UP000008984}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QM6a {ECO:0000313|EMBL:EGR46086.1,
RC   ECO:0000313|Proteomes:UP000008984};
RX   PubMed=18454138; DOI=10.1038/nbt1403;
RA   Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA   Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA   Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA   Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA   Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA   Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA   Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA   Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT   "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT   reesei (syn. Hypocrea jecorina).";
RL   Nat. Biotechnol. 26:553-560(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP +
CC         diphosphate + H(+) + lysidine(34) in tRNA(Ile2);
CC         Xref=Rhea:RHEA:43744, Rhea:RHEA-COMP:10625, Rhea:RHEA-COMP:10670,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:32551,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:82748, ChEBI:CHEBI:83665,
CC         ChEBI:CHEBI:456215; EC=6.3.4.19;
CC         Evidence={ECO:0000256|ARBA:ARBA00000047};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; GL985075; EGR46086.1; -; Genomic_DNA.
DR   RefSeq; XP_006968088.1; XM_006968026.1.
DR   AlphaFoldDB; G0RS43; -.
DR   STRING; 431241.G0RS43; -.
DR   EnsemblFungi; EGR46086; EGR46086; TRIREDRAFT_66877.
DR   GeneID; 18487515; -.
DR   KEGG; tre:TRIREDRAFT_66877; -.
DR   VEuPathDB; FungiDB:TRIREDRAFT_66877; -.
DR   eggNOG; ENOG502QQNE; Eukaryota.
DR   HOGENOM; CLU_015599_0_0_1; -.
DR   OrthoDB; 460053at2759; -.
DR   Proteomes; UP000008984; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016879; F:ligase activity, forming carbon-nitrogen bonds; IEA:InterPro.
DR   GO; GO:0006400; P:tRNA modification; IEA:UniProt.
DR   CDD; cd01992; PP-ATPase; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   HAMAP; MF_01161; tRNA_Ile_lys_synt; 1.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR011063; TilS/TtcA_N.
DR   InterPro; IPR012094; tRNA_Ile_lys_synt.
DR   InterPro; IPR012795; tRNA_Ile_lys_synt_N.
DR   NCBIfam; TIGR02432; lysidine_TilS_N; 1.
DR   PANTHER; PTHR43033; TRNA(ILE)-LYSIDINE SYNTHASE-RELATED; 1.
DR   PANTHER; PTHR43033:SF1; TRNA(ILE)-LYSIDINE SYNTHASE-RELATED; 1.
DR   Pfam; PF01171; ATP_bind_3; 2.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008984}.
FT   DOMAIN          45..218
FT                   /note="tRNA(Ile)-lysidine/2-thiocytidine synthase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01171"
FT   DOMAIN          279..328
FT                   /note="tRNA(Ile)-lysidine/2-thiocytidine synthase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01171"
FT   NON_TER         599
FT                   /evidence="ECO:0000313|EMBL:EGR46086.1"
SQ   SEQUENCE   599 AA;  68127 MW;  BEDDF7B9CDBA8B82 CRC64;
     MSAQALAFHH ASKPISVQEF RDAVLSVSRP RFPTALRRPR DPQPLAISGG VDSMAMAYLF
     SRLLRMYRGI KIADNPAETA FGVVVDHKLR EESTQEASRV TQELKRLGLK AIIKTLNWRE
     LKWQGIEPAT MPNIESVART MRYQALGSTC KYLQSSSLFF AHHQDDQYET VLMRLLAGHG
     YRGLQGIREA NAIPECYEMH SVYKSGLLDD QMQKRPFLSF KPPSREMKRL RHILRDDKDA
     EPWDQIRSYL SSSDKPMSFS SHFSRDFDPS VPYLTPLQSE DGGVTIYRPL VEFGKARLIA
     TCEANGVRWF EDSTNTDPTL TTRNAIRQLT RAHTLPKALQ KPSILALAQR SKRRVRLEEA
     EAHRLLVRER VIKDFDPNAG TLLIDVSTLW RASSSQMRRP FSQAREEARR RSRRLLAAIA
     LRKLIAFVTP ELHLPPLGNL ENAVDRLFPE LSGAIGTVPA AQPKAFSIAG VLFEPVPKRN
     AASWLLSRAP YSSRQPLPEQ KLPGYLNYRA GIFKMDGDGD QPSRHRHWRG WKTAKLWDGR
     FWIRVSACVA AKFQVLPFLP SSAKPFRMAL PPRERANLEK ILKHYAPGKV RYSLPGLYS
//
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