ID G0RS43_HYPJQ Unreviewed; 599 AA.
AC G0RS43;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=tRNA(Ile)-lysidine synthetase {ECO:0000256|ARBA:ARBA00013267};
DE EC=6.3.4.19 {ECO:0000256|ARBA:ARBA00013267};
DE Flags: Fragment;
GN ORFNames=TRIREDRAFT_66877 {ECO:0000313|EMBL:EGR46086.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR46086.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR46086.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP +
CC diphosphate + H(+) + lysidine(34) in tRNA(Ile2);
CC Xref=Rhea:RHEA:43744, Rhea:RHEA-COMP:10625, Rhea:RHEA-COMP:10670,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:32551,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:82748, ChEBI:CHEBI:83665,
CC ChEBI:CHEBI:456215; EC=6.3.4.19;
CC Evidence={ECO:0000256|ARBA:ARBA00000047};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; GL985075; EGR46086.1; -; Genomic_DNA.
DR RefSeq; XP_006968088.1; XM_006968026.1.
DR AlphaFoldDB; G0RS43; -.
DR STRING; 431241.G0RS43; -.
DR EnsemblFungi; EGR46086; EGR46086; TRIREDRAFT_66877.
DR GeneID; 18487515; -.
DR KEGG; tre:TRIREDRAFT_66877; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_66877; -.
DR eggNOG; ENOG502QQNE; Eukaryota.
DR HOGENOM; CLU_015599_0_0_1; -.
DR OrthoDB; 460053at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016879; F:ligase activity, forming carbon-nitrogen bonds; IEA:InterPro.
DR GO; GO:0006400; P:tRNA modification; IEA:UniProt.
DR CDD; cd01992; PP-ATPase; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR HAMAP; MF_01161; tRNA_Ile_lys_synt; 1.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR011063; TilS/TtcA_N.
DR InterPro; IPR012094; tRNA_Ile_lys_synt.
DR InterPro; IPR012795; tRNA_Ile_lys_synt_N.
DR NCBIfam; TIGR02432; lysidine_TilS_N; 1.
DR PANTHER; PTHR43033; TRNA(ILE)-LYSIDINE SYNTHASE-RELATED; 1.
DR PANTHER; PTHR43033:SF1; TRNA(ILE)-LYSIDINE SYNTHASE-RELATED; 1.
DR Pfam; PF01171; ATP_bind_3; 2.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984}.
FT DOMAIN 45..218
FT /note="tRNA(Ile)-lysidine/2-thiocytidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01171"
FT DOMAIN 279..328
FT /note="tRNA(Ile)-lysidine/2-thiocytidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01171"
FT NON_TER 599
FT /evidence="ECO:0000313|EMBL:EGR46086.1"
SQ SEQUENCE 599 AA; 68127 MW; BEDDF7B9CDBA8B82 CRC64;
MSAQALAFHH ASKPISVQEF RDAVLSVSRP RFPTALRRPR DPQPLAISGG VDSMAMAYLF
SRLLRMYRGI KIADNPAETA FGVVVDHKLR EESTQEASRV TQELKRLGLK AIIKTLNWRE
LKWQGIEPAT MPNIESVART MRYQALGSTC KYLQSSSLFF AHHQDDQYET VLMRLLAGHG
YRGLQGIREA NAIPECYEMH SVYKSGLLDD QMQKRPFLSF KPPSREMKRL RHILRDDKDA
EPWDQIRSYL SSSDKPMSFS SHFSRDFDPS VPYLTPLQSE DGGVTIYRPL VEFGKARLIA
TCEANGVRWF EDSTNTDPTL TTRNAIRQLT RAHTLPKALQ KPSILALAQR SKRRVRLEEA
EAHRLLVRER VIKDFDPNAG TLLIDVSTLW RASSSQMRRP FSQAREEARR RSRRLLAAIA
LRKLIAFVTP ELHLPPLGNL ENAVDRLFPE LSGAIGTVPA AQPKAFSIAG VLFEPVPKRN
AASWLLSRAP YSSRQPLPEQ KLPGYLNYRA GIFKMDGDGD QPSRHRHWRG WKTAKLWDGR
FWIRVSACVA AKFQVLPFLP SSAKPFRMAL PPRERANLEK ILKHYAPGKV RYSLPGLYS
//