ID G0S212_CHATD Unreviewed; 2104 AA.
AC G0S212;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Dedicator of cytokinesis protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CTHT_0015580 {ECO:0000313|EMBL:EGS23072.1};
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS (Thermochaetoides thermophila).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066};
RN [1] {ECO:0000313|EMBL:EGS23072.1, ECO:0000313|Proteomes:UP000008066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719
RC {ECO:0000313|Proteomes:UP000008066};
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; GL988039; EGS23072.1; -; Genomic_DNA.
DR RefSeq; XP_006692064.1; XM_006692001.1.
DR STRING; 759272.G0S212; -.
DR GeneID; 18255596; -.
DR KEGG; cthr:CTHT_0015580; -.
DR eggNOG; KOG1998; Eukaryota.
DR HOGENOM; CLU_000595_0_1_1; -.
DR OMA; LWDNQAF; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08679; C2_DOCK180_related; 1.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008066};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 7..87
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 605..791
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1412..1827
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 89..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1832..1876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1894..1918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1971..2007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2047..2078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2047..2061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2104 AA; 232055 MW; 8C927344F5FD99F7 CRC64;
MPWQPLPRIA FAVAIYPFAA QGPQDLPLEL GDELYIIEET SDGNWLRGYL VAPPSLLAGL
TSVKGQTLEA RVFSGIFPRS CVEIREVLGE SDESDESDAN SSSLTDEDGA APEPGERGVE
NKRRKAGSRK GGRSTSPGLL SVPVRRDPNA PRPPAPVPML KIGDETPTSA SEPLIDEIAS
CLREWHSTNL HELLLSRQYS KLDTLSHLIT SLNLARQQFL HDVLTSWEYE KLREKTVWDL
VKVNKLCGGE VIVRDPNARG RVLTGDDSVI EVTKLQSIMS LLEEPPTQPV ELTALHHLLV
DIKGFAGAST EATTLVLYLA IKPPGGTLKP LSECYIVEMP AGGQMGHLAR NAQMRTLFTD
LTAAEIGDVP ANEPELFLIV KIRASQQVVA VKPSSRSGSI SQALPQFAKD HKPPLSAGAK
SVRRSLMWAG KTTRSAFSRG NARLDSLSEQ PEETVGSPHT AGAESRDGMP PGTANSKSGG
GGRTSVDGHV AQATADRTVG VGILKLNSVM KQADEVEHIV TIWSPSVRVP ERNEAGEEWD
PIIRDLLESK TGHYEKSRRA ERVQVHLRAF NHPDADALIK ATPTMLAGVC KTNKMGFAGA
PTKPRSDIYL TLDEAVLSRQ TLLSRAGGSP TSLPNAVHGT NLQLTLEVRR STGERVESCI
YPSSNAEPAS AWKTVVTERG EKWRQTIRLS LSPSDVSQSH VVLHLADAPN PPFAIAFMPL
WDRQAFIHDG AHSLLLYRLD ENTSNAQPGS QGRGGYLSLP FAAAEDKRHH HGPGSEGSGP
LAMVRVDTYL CSTRFSQDRV VLGLLAWKES SREGIPHLLK QFIFVPEIEV VKLLNDVLDA
LFGILVEYSG NDDYEDLVFT ALVRVLDIVH DRRFNLAPLV DQYAETRFNY PFATLCLVRS
FIRLLSKPTE PETARKLRST FKVARHILKF ITHARSQQKA KEAGIGITGP NAGFTRHLRT
IFKALDSMMR SSAPVLIGSQ TLAVQHFHTW LPELTGLLST EEILHIAIDF MDSCSKVKGK
LILFKLVLII NYARLDIFSG AEQRSALSAN TVRWIAPHWG YTDEVTDQWR DQVRLCCSVL
ASQMDHLGPE IPDYIPKIIG KPISEPAIFD EALIELSAIL SALSSSPSGM QLELAEDDLH
VIVEKCLRVH MSILQGEAFP QNWLSVHIYH HKSAMRVLQY LASILLDSFL PHPDEAESFN
TELWKLFFTT LLKLVGSPSL ALETFPEQKR RAVWKIAGDV REHGADLLRK TWEAIGWETT
VEERARFGLS KLGGYQVQYV PTLVAPIVEL CLSVHEGLRR MAVEVLQTMI VSEWTLSEDL
SVIQTEMIDC LDAYFKAKPL TESILQKLFI GELLERFEPL RKVDSEDPLY KSLRELTDTV
DEFLDLLVAV HSGDGSGEAT HLIHRLRLME FLRDMQKEEI FIRYVHQLAN LQAQARNHTE
AGLALRLHAD LYDWDPLKTT PALHEPEFPA QSHFERKERI YFDMIKHFED GEAWSSALAA
YKELQTQYET NVFDFAKLAR TERAIASIYE HIVKSDKLVP KYFKVVFKGL GFPPSVRDKE
FVFEGSPNER TASFTDRMQE MYPAARIVTT EHIDDLEGQF LVISMLSPHR DPSHQVYQRA
RVPQIIRDYL LSANPQTFSV TVRRVTAGPV HEHFTDKLVY TTAEPFPTIL RRSEVVSVRE
VRLSAGETAL ERIVRKTAEM SSLEKKIADG EAGEDAAQLL LDAVAISVNP GSESSVAAYR
QLLPGAKERT SGSEQFDLED LEQAPELSPQ ENAIKMALVD HAIMLKRCLA TVAKFGSEQL
SKRVEELQRY FETTYAPEIA LFTPAPAIMS SSTAGLTSGT LRSSPSMSYP QQFQQQPTQQ
PKNGTSSSPT PEHKPAQSIS FLHGRAPRLS FLHSSRKKEH HHQRSATATN GADMKHPLYE
TEGNDTVVSL GAAKSVTSSV TGASTAKEGA STGHHGNRRS FFKVTSVPNL TGSSSGQGNT
NHNMNGDGSH HHRITAQPSS NVGSGVAAGM GVTNEWVTDA GTSSVAGTAS FEHHRNYGMA
EKDGAVVTTS NPVSSSGEGQ THGHGHGHHH HGSSIGSVRK RLSLLRLGKK SSRGAGMLGG
VDEE
//
