ID   G0S3Y1_CHATD            Unreviewed;      1033 AA.
AC   G0S3Y1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE   AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN   ORFNames=CTHT_0039280 {ECO:0000313|EMBL:EGS22043.1};
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS   (Thermochaetoides thermophila).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX   NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066};
RN   [1] {ECO:0000313|EMBL:EGS22043.1, ECO:0000313|Proteomes:UP000008066}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719
RC   {ECO:0000313|Proteomes:UP000008066};
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000256|ARBA:ARBA00002558}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
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DR   EMBL; GL988041; EGS22043.1; -; Genomic_DNA.
DR   RefSeq; XP_006694339.1; XM_006694276.1.
DR   AlphaFoldDB; G0S3Y1; -.
DR   STRING; 759272.G0S3Y1; -.
DR   GeneID; 18257966; -.
DR   KEGG; cthr:CTHT_0039280; -.
DR   eggNOG; KOG1421; Eukaryota.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   OMA; FWGHCVF; -.
DR   OrthoDB; 1779375at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.120; -; 2.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW   Protease {ECO:0000313|EMBL:EGS22043.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008066};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          398..474
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   DOMAIN          877..954
FT                   /note="PDZ-like"
FT                   /evidence="ECO:0000259|Pfam:PF12812"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1033 AA;  114682 MW;  77351AE77B0E39F4 CRC64;
     MNGAASAARS KRKDPPHPVD GRHPKHHRPN GDLSEEGTPH EEYESSAASG YDDYDELRLP
     SAAAIIPPTT ATTDSAEWQA TIQNVVKSVV SIRFCQTCSF DTDPGLCSEA TGFVVDAERG
     YILTNRHVVG AGPFWGFCIF DNHEEVDAYP VYRDPVHDFG ILKFDPKAIK YMPVRALPLR
     PDLAKVGVEI RVVGNDAGEK LSILSGVISR LDRNAPEYGE GYSDFNTCYY QASAAASGGS
     SGSPVVNIDG YAVALQAGGR ADGAATDYFL PLDRPLRALK CLQEGKPITR GDIQCQFLLK
     PFDECRRLGL TPEWEARVRK AFPKETNMLV AEIILPEGPS HGKIEEGDVL IKVNDELLTQ
     FIRLDDILDS NVGKPVKLLL LRGGKEVEVE IEVGDLHKIT PDRFVSVAGG SFHTLSYQQA
     RLYGVACKGV YVCEAGGSWR FDSAENGWLI QSVDHKKTPD LETFIEVMKN IPDKSRVVVT
     YKHLRDLHTL NTTIIYVDRH WSRKMKLAVR NDETGLWDFT NLADPLPPVP PVPRKASFIQ
     LDNTIHPAVA DLVRSFVHVS CTMPVKLDGF PKNRKWGMGL VVDAEKGLVI ISRAIVPYDL
     CDISITIADS IVVEGKVVFL HPLQNYAIIQ YDPKLVDAPV LSARLSTEEI TQGQPTYFIG
     YNRIGRIVHA ATTVTETFAV TIPANSGAPR YRAVNIDAIT VDTSLSGQCG SGVLVAQDGT
     VQALWLTYLG ERNPSTHRDE EYHLGFATPS IIPVVRQIQQ GVVPKLRMLS VELRAIQMSQ
     ARLMGVSEEW IHEVSLANTS HHQLFMVAKR TFERDTEHIP PDEQLLEGDV LLTLNGKIVT
     RISDLDVMYS HEYLDAVIVR DCQERRLRLR TVSADDVETT HAVSFCGAIL HRPHHAVRQQ
     ISKLFSEVYV SARTRGSPAY QYGLAPTNFI THVNGRPTPD LKSFLREVVK IPDNTYFRLR
     AMTFDSVPWV VTMKKCEHYF PTMELIKDPS EPCGWRRVTY ESGKVYQGEG PDGVVQPAGE
     STDMDVDMGV CDI
//