ID G0S5H5_CHATD Unreviewed; 428 AA.
AC G0S5H5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=6-phosphogluconate dehydrogenase NADP-binding domain-containing protein {ECO:0000259|Pfam:PF03446};
GN ORFNames=CTHT_0032980 {ECO:0000313|EMBL:EGS21440.1};
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS (Thermochaetoides thermophila).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066};
RN [1] {ECO:0000313|EMBL:EGS21440.1, ECO:0000313|Proteomes:UP000008066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719
RC {ECO:0000313|Proteomes:UP000008066};
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.
CC {ECO:0000256|ARBA:ARBA00007598}.
CC -!- SIMILARITY: Belongs to the V-ATPase e1/e2 subunit family.
CC {ECO:0000256|ARBA:ARBA00008328}.
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DR EMBL; GL988041; EGS21440.1; -; Genomic_DNA.
DR RefSeq; XP_006693736.1; XM_006693673.1.
DR AlphaFoldDB; G0S5H5; -.
DR STRING; 759272.G0S5H5; -.
DR GeneID; 18257336; -.
DR KEGG; cthr:CTHT_0032980; -.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_035117_5_1_1; -.
DR OMA; AWVQSTT; -.
DR OrthoDB; 2715114at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR008389; ATPase_V0-cplx_e1/e2_su.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580:SF3; 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600); 1.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF05493; ATP_synt_H; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008066};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..160
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
SQ SEQUENCE 428 AA; 47390 MW; 6484608BDF04C3FC CRC64;
MAPTLFWIGL GNMGRGMVKN LVEKGNLENP LLLWNRTKQR SIELSEKLPS GKTQVVDTIA
KGVPKADIIF IILSKDDVVE AAADEILKAG DVTGKLIIEC STLHPDTTTR LAKRFADHGA
QFVAAPVFGA PAMADAGMLI GVLAGPSAAV ERARPYFKGV MAREEIVMSD EPHAKALQMK
LVGNSFILNM VEQLAEAHVL AEKCGLGPQY VQKFVEQLFP GPYVAYSQRM LSGDYYKRKS
PLFAVDLARK DAAHIMSLAA ASGTRMKNVE TMDENLVRVK EHAGELGDYV AVYGILRKEA
GLNRTSNFRQ QESCMLKRFQ ELCVMSPCLA PIGMPLLELQ ANQHRAAHHH DACRQQPWSV
FIGLVIVSGM CVAAWVFSPK GENQVLWRSS LILSIVSCYL MWAITFLAQL HPLIEPRRSD
LRKEYIHH
//
